Dissociated glucocorticoids equipotently inhibit cytokine- and cAMP-induced matrix degrading proteases in rat mesangial cells

Dissociated glucocorticoids are synthetic ligands of the glucocorticoid receptor (GR) and which discriminate between transrepression and transactivation. These compounds were predicted to have large therapeutic benefits when compared to conventional glucocorticoids because of reduced side effects. I...

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Veröffentlicht in:	Biochemical pharmacology 2005-08, Vol.70 (3), p.433-445
Hauptverfasser:	Eberhardt, Wolfgang, Kilz, Tobias, Akool, El-Sayed, Müller, Roswitha, Pfeilschifter, Josef
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Cyclic AMP - antagonists & inhibitors Cyclic AMP - metabolism Cytokines - antagonists & inhibitors Cytokines - metabolism Dissociated glucocorticoids Extracellular matrix Extracellular Matrix - drug effects Extracellular Matrix - enzymology Glomerular Mesangium - cytology Glomerular Mesangium - drug effects Glomerular Mesangium - enzymology Glucocorticoids - chemistry Glucocorticoids - pharmacology Humans Matrix Metalloproteinase Inhibitors Matrix metalloproteinase-9 Matrix Metalloproteinases - metabolism Medical sciences Mouse mammary tumor virus Pharmacology. Drug treatments Protease Inhibitors - pharmacology Proteases Rats Tissue plasminogen activator
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