Adenoid Cystic Carcinoma of the Major Salivary Glands Treated with Surgery and Radiation
Objective: To examine patient characteristics, pathologic features, and treatment outcomes of adenoid cystic carcinoma of the major salivary glands. Study Design: Retrospective review of patients in an academic medical center. Method: Review of medical records regarding demographics, extent of tumor...
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| Veröffentlicht in: | The Laryngoscope 2005-07, Vol.115 (7), p.1278-1282 |
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| creator | Gurney, Theresa A. Eisele, David W. Weinberg, Vivian Shin, Ed Lee, Nancy |
| description | Objective: To examine patient characteristics, pathologic features, and treatment outcomes of adenoid cystic carcinoma of the major salivary glands.
Study Design: Retrospective review of patients in an academic medical center.
Method: Review of medical records regarding demographics, extent of tumor, stage, histologic characteristics, and treatment outcomes of patients treated with surgery and postoperative radiation.
Results: Of the 33 patients, 19 (58%) were male, and 14 (42%) were female. The average age of presentation was 49 (range 22–81) years. Of the 29 patients fully staged at the time of diagnosis, 7 (24%) presented at American Joint Committee on Cancer stage I, 9 (31%) at stage II, 4 (14%) at stage III, and 9 (31%) at stage IV. The cribriform histologic subtype was predominant (64%). The majority originated in the parotid gland (21, 64%), with the remaining originating in either the submandibular gland (10, 30%) or the sublingual gland (2, 6%). Local control was 94% at 5 years and 73% at 10 years. Metastatic control was 82% at 5 years and 63% at 10 years. Four patients failed locally and nine failed distally. Overall survival was 85% at 5 years and 69% at 10 years, with a median of 12.9 years.
Conclusion: Surgical excision with postoperative radiation provides a long period of disease‐free survival. Patients were more likely to fail with metastases than with local recurrence. |
| doi_str_mv | 10.1097/01.MLG.0000165381.64157.AD |
| format | Article |
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Study Design: Retrospective review of patients in an academic medical center.
Method: Review of medical records regarding demographics, extent of tumor, stage, histologic characteristics, and treatment outcomes of patients treated with surgery and postoperative radiation.
Results: Of the 33 patients, 19 (58%) were male, and 14 (42%) were female. The average age of presentation was 49 (range 22–81) years. Of the 29 patients fully staged at the time of diagnosis, 7 (24%) presented at American Joint Committee on Cancer stage I, 9 (31%) at stage II, 4 (14%) at stage III, and 9 (31%) at stage IV. The cribriform histologic subtype was predominant (64%). The majority originated in the parotid gland (21, 64%), with the remaining originating in either the submandibular gland (10, 30%) or the sublingual gland (2, 6%). Local control was 94% at 5 years and 73% at 10 years. Metastatic control was 82% at 5 years and 63% at 10 years. Four patients failed locally and nine failed distally. Overall survival was 85% at 5 years and 69% at 10 years, with a median of 12.9 years.
Conclusion: Surgical excision with postoperative radiation provides a long period of disease‐free survival. Patients were more likely to fail with metastases than with local recurrence.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1097/01.MLG.0000165381.64157.AD</identifier><identifier>PMID: 15995521</identifier><identifier>CODEN: LARYA8</identifier><language>eng</language><publisher>Hoboken, NJ: John Wiley & Sons, Inc</publisher><subject>Adenoid cystic carcinoma ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Carcinoma, Adenoid Cystic - mortality ; Carcinoma, Adenoid Cystic - radiotherapy ; Carcinoma, Adenoid Cystic - surgery ; Combined Modality Therapy ; Demography ; Disease-Free Survival ; Female ; Humans ; major salivary glands ; Male ; Medical Records ; Medical sciences ; Middle Aged ; Otorhinolaryngology. Stomatology ; Postoperative Care ; postoperative radiation ; Retrospective Studies ; Salivary Gland Neoplasms - mortality ; Salivary Gland Neoplasms - radiotherapy ; Salivary Gland Neoplasms - surgery</subject><ispartof>The Laryngoscope, 2005-07, Vol.115 (7), p.1278-1282</ispartof><rights>Copyright © 2005 The Triological Society</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5005-6b560036b0cc0cec8a41bf68a13825d4d6567c53229b33f3268279850918e2573</citedby><cites>FETCH-LOGICAL-c5005-6b560036b0cc0cec8a41bf68a13825d4d6567c53229b33f3268279850918e2573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2F01.MLG.0000165381.64157.AD$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2F01.MLG.0000165381.64157.AD$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16941093$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15995521$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gurney, Theresa A.</creatorcontrib><creatorcontrib>Eisele, David W.</creatorcontrib><creatorcontrib>Weinberg, Vivian</creatorcontrib><creatorcontrib>Shin, Ed</creatorcontrib><creatorcontrib>Lee, Nancy</creatorcontrib><title>Adenoid Cystic Carcinoma of the Major Salivary Glands Treated with Surgery and Radiation</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objective: To examine patient characteristics, pathologic features, and treatment outcomes of adenoid cystic carcinoma of the major salivary glands.
Study Design: Retrospective review of patients in an academic medical center.
Method: Review of medical records regarding demographics, extent of tumor, stage, histologic characteristics, and treatment outcomes of patients treated with surgery and postoperative radiation.
Results: Of the 33 patients, 19 (58%) were male, and 14 (42%) were female. The average age of presentation was 49 (range 22–81) years. Of the 29 patients fully staged at the time of diagnosis, 7 (24%) presented at American Joint Committee on Cancer stage I, 9 (31%) at stage II, 4 (14%) at stage III, and 9 (31%) at stage IV. The cribriform histologic subtype was predominant (64%). The majority originated in the parotid gland (21, 64%), with the remaining originating in either the submandibular gland (10, 30%) or the sublingual gland (2, 6%). Local control was 94% at 5 years and 73% at 10 years. Metastatic control was 82% at 5 years and 63% at 10 years. Four patients failed locally and nine failed distally. Overall survival was 85% at 5 years and 69% at 10 years, with a median of 12.9 years.
Conclusion: Surgical excision with postoperative radiation provides a long period of disease‐free survival. Patients were more likely to fail with metastases than with local recurrence.</description><subject>Adenoid cystic carcinoma</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Adenoid Cystic - mortality</subject><subject>Carcinoma, Adenoid Cystic - radiotherapy</subject><subject>Carcinoma, Adenoid Cystic - surgery</subject><subject>Combined Modality Therapy</subject><subject>Demography</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>major salivary glands</subject><subject>Male</subject><subject>Medical Records</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Postoperative Care</subject><subject>postoperative radiation</subject><subject>Retrospective Studies</subject><subject>Salivary Gland Neoplasms - mortality</subject><subject>Salivary Gland Neoplasms - radiotherapy</subject><subject>Salivary Gland Neoplasms - surgery</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkE1v1DAQhi0EokvhLyALCW4J_sj4g1u6pQtoF6S2iMLFchyHus0mxc5S9t9j2BV7xhcf5pl3Zh6EXlBSUqLla0LL1XJRkvyoAK5oKSoKsqxPH6AZBU6LSmt4iGaEMF4oYFdH6ElKNxmXHMhjdEQhA8DoDF3VrR_G0OL5Nk3B4bmNLgzj2uKxw9O1xyt7M0Z8Yfvw08YtXvR2aBO-jN5OvsX3YbrGF5v43edaruBz2wY7hXF4ih51tk_-2f4_Rp_P3l7O3xXLT4v383pZOCAECtGAIISLhjhHnHfKVrTphLKUKwZt1QoQ0gFnTDecd5wJxaRWQDRVnoHkx-jVLvcujj82Pk1mHZLzfd7Tj5tkhNRaaFVl8M0OdHFMKfrO3MWwzjcZSswfr4ZQk72ag1fz16upT3Pz8_2UTbP27aF1LzIDL_eATc72XbSDC-nACV3lGTxzZzvuPvR--x8rmGV9_hWgohSIZJCDil1QSJP_9S_Ixtt8MpdgvnxcmG8nq9UJ_VAZxn8DVz2iTA</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Gurney, Theresa A.</creator><creator>Eisele, David W.</creator><creator>Weinberg, Vivian</creator><creator>Shin, Ed</creator><creator>Lee, Nancy</creator><general>John Wiley & Sons, Inc</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>200507</creationdate><title>Adenoid Cystic Carcinoma of the Major Salivary Glands Treated with Surgery and Radiation</title><author>Gurney, Theresa A. ; Eisele, David W. ; Weinberg, Vivian ; Shin, Ed ; Lee, Nancy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5005-6b560036b0cc0cec8a41bf68a13825d4d6567c53229b33f3268279850918e2573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adenoid cystic carcinoma</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Adenoid Cystic - mortality</topic><topic>Carcinoma, Adenoid Cystic - radiotherapy</topic><topic>Carcinoma, Adenoid Cystic - surgery</topic><topic>Combined Modality Therapy</topic><topic>Demography</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>major salivary glands</topic><topic>Male</topic><topic>Medical Records</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Postoperative Care</topic><topic>postoperative radiation</topic><topic>Retrospective Studies</topic><topic>Salivary Gland Neoplasms - mortality</topic><topic>Salivary Gland Neoplasms - radiotherapy</topic><topic>Salivary Gland Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gurney, Theresa A.</creatorcontrib><creatorcontrib>Eisele, David W.</creatorcontrib><creatorcontrib>Weinberg, Vivian</creatorcontrib><creatorcontrib>Shin, Ed</creatorcontrib><creatorcontrib>Lee, Nancy</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gurney, Theresa A.</au><au>Eisele, David W.</au><au>Weinberg, Vivian</au><au>Shin, Ed</au><au>Lee, Nancy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adenoid Cystic Carcinoma of the Major Salivary Glands Treated with Surgery and Radiation</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2005-07</date><risdate>2005</risdate><volume>115</volume><issue>7</issue><spage>1278</spage><epage>1282</epage><pages>1278-1282</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><coden>LARYA8</coden><abstract>Objective: To examine patient characteristics, pathologic features, and treatment outcomes of adenoid cystic carcinoma of the major salivary glands.
Study Design: Retrospective review of patients in an academic medical center.
Method: Review of medical records regarding demographics, extent of tumor, stage, histologic characteristics, and treatment outcomes of patients treated with surgery and postoperative radiation.
Results: Of the 33 patients, 19 (58%) were male, and 14 (42%) were female. The average age of presentation was 49 (range 22–81) years. Of the 29 patients fully staged at the time of diagnosis, 7 (24%) presented at American Joint Committee on Cancer stage I, 9 (31%) at stage II, 4 (14%) at stage III, and 9 (31%) at stage IV. The cribriform histologic subtype was predominant (64%). The majority originated in the parotid gland (21, 64%), with the remaining originating in either the submandibular gland (10, 30%) or the sublingual gland (2, 6%). Local control was 94% at 5 years and 73% at 10 years. Metastatic control was 82% at 5 years and 63% at 10 years. Four patients failed locally and nine failed distally. Overall survival was 85% at 5 years and 69% at 10 years, with a median of 12.9 years.
Conclusion: Surgical excision with postoperative radiation provides a long period of disease‐free survival. Patients were more likely to fail with metastases than with local recurrence.</abstract><cop>Hoboken, NJ</cop><pub>John Wiley & Sons, Inc</pub><pmid>15995521</pmid><doi>10.1097/01.MLG.0000165381.64157.AD</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Laryngoscope, 2005-07, Vol.115 (7), p.1278-1282 |
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| language | eng |
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| subjects | Adenoid cystic carcinoma Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Adenoid Cystic - mortality Carcinoma, Adenoid Cystic - radiotherapy Carcinoma, Adenoid Cystic - surgery Combined Modality Therapy Demography Disease-Free Survival Female Humans major salivary glands Male Medical Records Medical sciences Middle Aged Otorhinolaryngology. Stomatology Postoperative Care postoperative radiation Retrospective Studies Salivary Gland Neoplasms - mortality Salivary Gland Neoplasms - radiotherapy Salivary Gland Neoplasms - surgery |
| title | Adenoid Cystic Carcinoma of the Major Salivary Glands Treated with Surgery and Radiation |
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