Regulated expression of platelet factor 4 in human monocytes—role of PARs as a quantitatively important monocyte activation pathway

Human mononuclear phagocytes have recently been shown to express constitutively and even more so, upon stimulation with bacteria, fungi, lipopolysaccharide (LPS), zymosan, or thrombin platelet basic protein (PBP). This CXC chemokine as well as platelet factor 4 (PF4), which is located genomically at...

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Veröffentlicht in:	Journal of leukocyte biology 2005-07, Vol.78 (1), p.202-209
Hauptverfasser:	Schaffner, Andreas, Rhyn, Petra, Schoedon, Gabriela, Schaer, Dominik J.
Format:	Artikel
Sprache:	eng
Schlagworte:	antimicrobial cationic peptides Cells, Cultured Chemokine CCL2 - drug effects Chemokine CCL2 - immunology Chemokine CCL4 Chemokine CCL5 - immunology chemokines Chemokines, CXC - immunology Chemotaxis, Leukocyte - drug effects Chemotaxis, Leukocyte - immunology Humans Inflammation Mediators - pharmacology Interleukin-8 - immunology Interleukin-8 - metabolism Macrophage Inflammatory Proteins - immunology macrophages Monocytes - drug effects Monocytes - immunology Monocytes - metabolism Peptide Fragments - pharmacology Platelet Factor 4 - genetics Platelet Factor 4 - immunology proteinase‐activated Receptor, PAR-1 - drug effects Receptor, PAR-1 - immunology Receptor, PAR-2 - drug effects Receptor, PAR-2 - immunology receptors Receptors, Proteinase-Activated - drug effects Receptors, Proteinase-Activated - immunology RNA, Messenger - metabolism Signal Transduction - drug effects Signal Transduction - immunology thrombin Thrombin - metabolism Transcriptional Activation - genetics Up-Regulation - drug effects Up-Regulation - immunology β‐thromboglobulin
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