Anergic lymphocytes generated by blocking CD28 and ICOS pathways in vitro prolong rat cardiac graft survival

Regulatory cells may play a pivotal role in inducing and maintaining transplantation tolerance. We investigated the mechanism of anergic lymphocytes with regulatory cell potential generated in vitro by ICOS and CD28 co-stimulatory blockades as a source of cellular therapy for treating allograft reje...

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Veröffentlicht in:	International immunopharmacology 2006-07, Vol.6 (7), p.1143-1151
Hauptverfasser:	Hara, Yoshiaki, Kitazawa, Yusuke, Funeshima, Naoko, Kawasaki, Mikiko, Sato, Yoshinobu, Tezuka, Katsunari, Kimura, Hiromitsu, Hatakeyama, Katsuyoshi, Li, Xiao-Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	Abatacept Anergic lymphocytes Animals Antibodies, Monoclonal - pharmacology Antigens, Differentiation, T-Lymphocyte - immunology Biological and medical sciences CD28 Antigens - immunology Cells, Cultured Clonal Anergy - immunology Co-stimulatory molecular Cytokines - immunology Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Graft Rejection - immunology Graft Survival - immunology Heart Transplantation - immunology Immunoconjugates - pharmacology Immunoglobulin G - immunology Inducible T-Cell Co-Stimulator Protein Lymph Nodes - immunology Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Lew Recombinant Proteins - pharmacology Regulatory T cells RNA, Messenger - metabolism Spleen - cytology Spleen - drug effects Spleen - immunology T-Lymphocyte Subsets - drug effects T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes - drug effects T-Lymphocytes - immunology T-Lymphocytes - metabolism Tolerance Transplantation
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