Inhibitory effect of JTP-59557, a new triazole derivative, on intestinal phosphate transport in vitro and in vivo

JTP-59557 [(−)-4-(2- tert-Butyl-4,5-dichlorophenyl)-5-(5-trifluoromethylpyridin-2-ylsulfanyl)-4H-[1,2,4]triazol-3-ol] showed an inhibitory effect on Na +-dependent inorganic phosphate (Pi) transport in intestinal brush border membrane vesicles with an IC 50 value of 0.40 μM in rabbit and with an IC...

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Veröffentlicht in:	European journal of pharmacology 2005-07, Vol.517 (1), p.111-119
Hauptverfasser:	Matsuo, Akira, Negoro, Tamotsu, Seo, Tomohisa, Kitao, Yuki, Shindo, Masanori, Segawa, Hiroko, Miyamoto, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biological Transport - drug effects CHO Cells Cricetinae Cricetulus Dose-Response Relationship, Drug Foscarnet - pharmacology Gene Expression Humans Intestinal Absorption - drug effects Intestinal Na +-dependent Pi transport Intestines - drug effects Intestines - metabolism Intestines - surgery JTP-59557 Kinetics Ligation Male Medical sciences Microvilli - drug effects Microvilli - metabolism Pharmacology. Drug treatments Phosphates - pharmacokinetics Phosphorus, Dietary - pharmacokinetics Pi absorption Rabbits Rats Rats, Sprague-Dawley Sodium-Phosphate Cotransporter Proteins Sodium-Phosphate Cotransporter Proteins, Type IIb Symporters - genetics Symporters - metabolism Triazoles - pharmacology Type IIb Na/Pi cotransporter
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