Advances in tuberculosis vaccine strategies
Yasir Skeiky and Jerry Sadoff outline the current state of play in the development of effective vaccines against Mycobacterium tuberculosis . Promising strategies include the use of modified recombinant BCG, live attenuated M. tuberculosis and subunit vaccines alone or in prime?boost regimens to opt...
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| Veröffentlicht in: | Nature reviews. Microbiology 2006-06, Vol.4 (6), p.469-476 |
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| creator | Skeiky, Yasir A. W. Sadoff, Jerald C. |
| description | Yasir Skeiky and Jerry Sadoff outline the current state of play in the development of effective vaccines against
Mycobacterium tuberculosis
. Promising strategies include the use of modified recombinant BCG, live attenuated
M. tuberculosis
and subunit vaccines alone or in prime?boost regimens to optimize immunity and vaccine safety.
Tuberculosis (TB), an ancient human scourge, is a growing health problem in the developing world. Approximately two million deaths each year are caused by TB, which is the leading cause of death in HIV-infected individuals. Clearly, an improved TB vaccine is desperately needed. Heterologous prime?boost regimens probably represent the best hope for an improved vaccine regimen to prevent TB. This first generation of new vaccines might also complement drug treatment regimens and be effective against reactivation of TB from the latent state, which would significantly enhance their usefulness. |
| doi_str_mv | 10.1038/nrmicro1419 |
| format | Article |
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Mycobacterium tuberculosis
. Promising strategies include the use of modified recombinant BCG, live attenuated
M. tuberculosis
and subunit vaccines alone or in prime?boost regimens to optimize immunity and vaccine safety.
Tuberculosis (TB), an ancient human scourge, is a growing health problem in the developing world. Approximately two million deaths each year are caused by TB, which is the leading cause of death in HIV-infected individuals. Clearly, an improved TB vaccine is desperately needed. Heterologous prime?boost regimens probably represent the best hope for an improved vaccine regimen to prevent TB. This first generation of new vaccines might also complement drug treatment regimens and be effective against reactivation of TB from the latent state, which would significantly enhance their usefulness.</description><identifier>ISSN: 1740-1526</identifier><identifier>EISSN: 1740-1534</identifier><identifier>DOI: 10.1038/nrmicro1419</identifier><identifier>PMID: 16710326</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Antigens ; Apoptosis ; BCG Vaccine - immunology ; Biomedical and Life Sciences ; Granulomas ; Humans ; Infections ; Infectious Diseases ; Life Sciences ; Lymphocytes ; Medical Microbiology ; Microbiology ; Mycobacterium tuberculosis - immunology ; Mycobacterium tuberculosis - pathogenicity ; Parasitology ; science-and-society ; Time ; Tuberculosis ; Tuberculosis - immunology ; Tuberculosis - microbiology ; Tuberculosis - prevention & control ; Tuberculosis Vaccines - immunology ; Tuberculosis Vaccines - standards ; Vaccination - standards ; Vaccination - trends ; Vaccines ; Vaccines, Attenuated - immunology ; Vaccines, Subunit - immunology ; Virology</subject><ispartof>Nature reviews. Microbiology, 2006-06, Vol.4 (6), p.469-476</ispartof><rights>Springer Nature Limited 2006</rights><rights>COPYRIGHT 2006 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-de3628e33c9f475d55ef03707fd0db4e28c46152531a33da365b62e5a05946d73</citedby><cites>FETCH-LOGICAL-c455t-de3628e33c9f475d55ef03707fd0db4e28c46152531a33da365b62e5a05946d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nrmicro1419$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nrmicro1419$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16710326$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Skeiky, Yasir A. W.</creatorcontrib><creatorcontrib>Sadoff, Jerald C.</creatorcontrib><title>Advances in tuberculosis vaccine strategies</title><title>Nature reviews. Microbiology</title><addtitle>Nat Rev Microbiol</addtitle><addtitle>Nat Rev Microbiol</addtitle><description>Yasir Skeiky and Jerry Sadoff outline the current state of play in the development of effective vaccines against
Mycobacterium tuberculosis
. Promising strategies include the use of modified recombinant BCG, live attenuated
M. tuberculosis
and subunit vaccines alone or in prime?boost regimens to optimize immunity and vaccine safety.
Tuberculosis (TB), an ancient human scourge, is a growing health problem in the developing world. Approximately two million deaths each year are caused by TB, which is the leading cause of death in HIV-infected individuals. Clearly, an improved TB vaccine is desperately needed. Heterologous prime?boost regimens probably represent the best hope for an improved vaccine regimen to prevent TB. This first generation of new vaccines might also complement drug treatment regimens and be effective against reactivation of TB from the latent state, which would significantly enhance their usefulness.</description><subject>Antigens</subject><subject>Apoptosis</subject><subject>BCG Vaccine - immunology</subject><subject>Biomedical and Life Sciences</subject><subject>Granulomas</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious Diseases</subject><subject>Life Sciences</subject><subject>Lymphocytes</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Mycobacterium tuberculosis - immunology</subject><subject>Mycobacterium tuberculosis - pathogenicity</subject><subject>Parasitology</subject><subject>science-and-society</subject><subject>Time</subject><subject>Tuberculosis</subject><subject>Tuberculosis - immunology</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis - prevention & control</subject><subject>Tuberculosis Vaccines - immunology</subject><subject>Tuberculosis Vaccines - standards</subject><subject>Vaccination - standards</subject><subject>Vaccination - trends</subject><subject>Vaccines</subject><subject>Vaccines, Attenuated - immunology</subject><subject>Vaccines, Subunit - immunology</subject><subject>Virology</subject><issn>1740-1526</issn><issn>1740-1534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptkc1LAzEQxYMotlZP3qUoeKmt-d7dYyl-QcGLnkOazJaUbbYmuwX_e7O0WBXJIWHym8ebeQhdEjwhmOX3PqydCTXhpDhCfZJxPCaC8ePvN5U9dBbjCmMqREZPUY_ILLVS2Uejqd1qbyAOnR827QKCaas6ujjcamOch2Fsgm5g6SCeo5NSVxEu9vcAvT8-vM2ex_PXp5fZdD42XIhmbIFJmgNjpih5JqwQUGKW4ay02C440NxwmVwJRjRjVjMpFpKC0FgUXNqMDdDtTncT6o8WYqPWLhqoKu2hbqOSWVFIyjrw-g-4qtvgkzdFKZcsl4Qm6GYHLXUFyvmyTgOZTlFNSZ4XIie0oyb_UOlYSNutPZQu1X81jHYNafUxBijVJri1Dp-KYNXlon7kkuirvdN2sQZ7YPdBJOBuB8T05ZcQDqP8p_cFiuuVmA</recordid><startdate>20060601</startdate><enddate>20060601</enddate><creator>Skeiky, Yasir A. 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Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Skeiky, Yasir A. W.</au><au>Sadoff, Jerald C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Advances in tuberculosis vaccine strategies</atitle><jtitle>Nature reviews. Microbiology</jtitle><stitle>Nat Rev Microbiol</stitle><addtitle>Nat Rev Microbiol</addtitle><date>2006-06-01</date><risdate>2006</risdate><volume>4</volume><issue>6</issue><spage>469</spage><epage>476</epage><pages>469-476</pages><issn>1740-1526</issn><eissn>1740-1534</eissn><abstract>Yasir Skeiky and Jerry Sadoff outline the current state of play in the development of effective vaccines against
Mycobacterium tuberculosis
. Promising strategies include the use of modified recombinant BCG, live attenuated
M. tuberculosis
and subunit vaccines alone or in prime?boost regimens to optimize immunity and vaccine safety.
Tuberculosis (TB), an ancient human scourge, is a growing health problem in the developing world. Approximately two million deaths each year are caused by TB, which is the leading cause of death in HIV-infected individuals. Clearly, an improved TB vaccine is desperately needed. Heterologous prime?boost regimens probably represent the best hope for an improved vaccine regimen to prevent TB. This first generation of new vaccines might also complement drug treatment regimens and be effective against reactivation of TB from the latent state, which would significantly enhance their usefulness.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>16710326</pmid><doi>10.1038/nrmicro1419</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Nature; Springer Nature - Complete Springer Journals |
| subjects | Antigens Apoptosis BCG Vaccine - immunology Biomedical and Life Sciences Granulomas Humans Infections Infectious Diseases Life Sciences Lymphocytes Medical Microbiology Microbiology Mycobacterium tuberculosis - immunology Mycobacterium tuberculosis - pathogenicity Parasitology science-and-society Time Tuberculosis Tuberculosis - immunology Tuberculosis - microbiology Tuberculosis - prevention & control Tuberculosis Vaccines - immunology Tuberculosis Vaccines - standards Vaccination - standards Vaccination - trends Vaccines Vaccines, Attenuated - immunology Vaccines, Subunit - immunology Virology |
| title | Advances in tuberculosis vaccine strategies |
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