Copy number polymorphism and expression level variation of the human α-defensin genes DEFA1 and DEFA3

We have defined unexpectedly extensive copy number variation at the human anti-microbial α-defensin genes DEFA1 and DEFA3, encoding human neutrophil peptides HNP-1, HNP-2 and HNP-3. There was variation in both number and position of DEFA1/DEFA3 genes in arrays of 19 kb tandem repeats on 8p23.1, so t...

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