Development of a Novel Nitro-Derivative of Noscapine for the Potential Treatment of Drug-Resistant Ovarian Cancer and T-Cell Lymphoma

We have shown previously that an antitussive plant alkaloid, noscapine, binds tubulin, displays anticancer activity, and has a safe pharmacological profile in humans. Structure-function analyses pointed to a proton at position-9 of the isoquinoline ring that can be modified without compromising tubu...

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Veröffentlicht in:	Molecular pharmacology 2006-06, Vol.69 (6), p.1801-1809
Hauptverfasser:	Aneja, Ritu, Vangapandu, Surya N., Lopus, Manu, Chandra, Ramesh, Panda, Dulal, Joshi, Harish C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimitotic Agents - chemical synthesis Antimitotic Agents - pharmacology Antimitotic Agents - therapeutic use Antineoplastic Agents - therapeutic use Apoptosis Caspase 3 Caspases - metabolism Cell Cycle - drug effects DNA Fragmentation Drug Resistance, Neoplasm Enzyme Activation Female Humans Lymphoma, T-Cell - drug therapy Noscapine - analogs & derivatives Noscapine - chemical synthesis Noscapine - chemistry Noscapine - pharmacology Noscapine - therapeutic use Ovarian Neoplasms - drug therapy Tubulin - drug effects Tubulin - metabolism Vinca
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