Design, synthesis, and evaluation of LeuAla hydroxyethylene-based non-peptide β-secretase (BACE) inhibitors

With the aim of developing small molecular non-peptide beta-secretase (BACE) inhibitors, Leu*Ala hydroxyethylene (HE) was investigated as a scaffold to design and synthesize a series of compounds. Taking advantage of efficient combinatorial synthesis approaches and molecular modeling, extensive stru...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2006-07, Vol.14 (13), p.4535-4551
Hauptverfasser:	Xiao, Kun, Li, Xin, Li, Jingya, Ma, Lanping, Hu, Bin, Yu, Haiping, Fu, Yan, Wang, Rui, Ma, Zeqiang, Qiu, Beiying, Li, Jia, Hu, Dingyu, Wang, Xin, Shen, Jingkang
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyloid Precursor Protein Secretases Aspartic Acid Endopeptidases Benzamides - chemistry Biological and medical sciences Carbamates - chemistry Dipeptides - chemistry Drug Design Endopeptidases - chemistry Endopeptidases - drug effects Ethylenes - chemistry Humans Medical sciences Molecular Structure Neuropharmacology Nitrobenzenes - chemistry Oligopeptides - pharmacology Peptides - pharmacology Pharmacology. Drug treatments Protease Inhibitors - chemical synthesis Protease Inhibitors - chemistry Protease Inhibitors - pharmacology Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopharmacology
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