Preparation and in vitro evaluation of chitosan nanoparticles containing a caspase inhibitor

The aim of this work was to develop a formulation for Z-DEVD-FMK, a peptide which is a caspase inhibitor and has been used in experimental animal studies for a decade. Peptide loaded chitosan nanoparticles were obtained by ionotropic gelation process and Z-DEVD-FMK was quantified by an HPLC method....

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Veröffentlicht in:	International journal of pharmaceutics 2005-07, Vol.298 (2), p.378-383
Hauptverfasser:	Aktaş, Yeşim, Andrieux, Karine, Alonso, Maria Jose, Calvo, Pilar, Gürsoy, R. Neslihan, Couvreur, Patrick, Çapan, Yılmaz
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Caspase Inhibitors Chemical Phenomena Chemistry, Physical Chitosan Chitosan - chemistry Chromatography, High Pressure Liquid Electrochemistry Gels General pharmacology HPLC Medical sciences Microscopy, Electron, Transmission Nanoparticles Nanostructures Oligopeptides - administration & dosage Oligopeptides - chemistry Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Protease Inhibitors - administration & dosage Protease Inhibitors - chemistry Z-DEVD-FMK
Online-Zugang:	Volltext
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