Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors

Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate (TG41) enhanced the binding both of γ-aminobutyric acid (GABA) and of flunitrazepam to rat cerebral cortical membranes. Electrophysiological recordings from Xenopus oocytes expressing various recombinant GABAA receptor subtypes...

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Veröffentlicht in:	European journal of pharmacology 2005-06, Vol.516 (3), p.204-211
Hauptverfasser:	Mascia, Maria Paola, Asproni, Battistina, Busonero, Fabio, Talani, Giuseppe, Maciocco, Elisabetta, Pau, Amedeo, Cerri, Riccardo, Sanna, Enrico, Biggio, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive - drug effects Biological and medical sciences Cell Membrane - drug effects Cell Membrane - metabolism Cerebral Cortex - drug effects Cerebral Cortex - metabolism Diazepam - pharmacology Dose-Response Relationship, Drug Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate Etomidate - pharmacology Female Flunitrazepam - metabolism GABA Modulators - pharmacology gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - pharmacology Glycine - pharmacology Humans Hydrocarbons, Halogenated - pharmacology Imidazoles - pharmacology Male Medical sciences Membrane Potentials - drug effects Oocytes - drug effects Oocytes - metabolism Oocytes - physiology Pentobarbital - pharmacology Pharmacology. Drug treatments Pregnanediones - pharmacology Propofol - pharmacology Rats Rats, Sprague-Dawley Receptors, GABA-A - drug effects Receptors, GABA-A - genetics Receptors, GABA-A - physiology Receptors, Glycine - genetics Receptors, Glycine - physiology Receptors, Serotonin, 5-HT3 - genetics Receptors, Serotonin, 5-HT3 - physiology Serotonin - pharmacology Transmembrane domain Tritium Xenopus laevis γ-Aminobutyric acid
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