The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer

S100A7 is among the most highly expressed genes in preinvasive breast cancer, is a marker of poor survival when expressed in invasive disease, and promotes breast tumor progression in experimental models. To explore the mechanism of action, we examined the role of S100A7 in cell survival and found t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-07, Vol.65 (13), p.5696-5702
Hauptverfasser:	EMBERLEY, Ethan D, YULIAN NIU, CURTIS, Linda, TROUP, Sandra, MANDAL, Sanat K, MYERS, Jeffery N, GIBSON, Spencer B, MURPHY, Leigh C, WATSON, Peter H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Calcium-Binding Proteins - biosynthesis Calcium-Binding Proteins - genetics Calcium-Binding Proteins - physiology Cell Adhesion - physiology Cell Line, Tumor Cell Survival - physiology COP9 Signalosome Complex DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Enzyme Activation Female Humans Intracellular Signaling Peptides and Proteins Medical sciences Mice Mice, Nude Mutation Neoplasm Transplantation NF-kappa B - metabolism Peptide Hydrolases - metabolism Peptide Hydrolases - physiology Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Protein-Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-akt S100 Calcium Binding Protein A7 S100 Proteins Transcription Factors - metabolism Transcription Factors - physiology Transplantation, Heterologous Tumors
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