Assessing the efficacy of within-animal control strategies against E. coli O157: A simulation study
A stochastic simulation model was used to assess the efficacy of potential measures to control the levels of Escherichia coli O157 within the bovine host. The model described E. coli O157 population sizes at several sites along the bovine gut and therefore only interventions that operate at an indiv...
Gespeichert in:
| Veröffentlicht in: | Preventive veterinary medicine 2006-05, Vol.74 (2), p.194-211 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 211 |
|---|---|
| container_issue | 2 |
| container_start_page | 194 |
| container_title | Preventive veterinary medicine |
| container_volume | 74 |
| creator | Wood, J.C. McKendrick, I.J. Gettinby, G. |
| description | A stochastic simulation model was used to assess the efficacy of potential measures to control the levels of
Escherichia coli O157 within the bovine host. The model described
E. coli O157 population sizes at several sites along the bovine gut and therefore only interventions that operate at an individual animal level could be evaluated. In order to use the model to evaluate the control strategies, it was necessary to make assumptions about how each strategy affected
E. coli O157 populations in vivo. The within-animal conditions under these control strategies were modelled by adjusting the growth rates of
E. coli O157 at specific sites of interest in the gut, based on these assumptions. The model simulated the population dynamics of an initial dose of
E. coli O157 inoculated into an animal in the presence of inhibitory probiotics or antibiotics, bactericidal antibiotics or probiotics, and following fasting. Of the control strategies considered, the use of inhibitory probiotics appeared most promising and continued development of a suitable product is to be encouraged. |
| doi_str_mv | 10.1016/j.prevetmed.2005.11.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_67993355</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167587705003351</els_id><sourcerecordid>67993355</sourcerecordid><originalsourceid>FETCH-LOGICAL-c393t-4126195e11007002d6fc0af0b87c2673be97ccce5aa298a3c1ef20e9fc61445f3</originalsourceid><addsrcrecordid>eNqFkD1v2zAQhomiReOm_QsNp25S70SRlLoZQfoBBMjQZiZo6ujQkCWXpBL435eGjaydbrjnvY-HsRuEGgHV1119iPRMeU9D3QDIGrEGhDdshZ0WFWpUb9mqkLqSndZX7ENKOwBQqpPv2RWqVrUSccXcOiVKKUxbnp-Ik_fBWXfks-cvIT-FqbJT2NuRu3nKcR55ytFm2gZK3G5tmFLmd3XpjoE_oNTf-JqnsF9Gm8M8FXoZjh_ZO2_HRJ8u9Zo9fr_7c_uzun_48et2fV850Ytctdgo7CUhAmiAZlDegfWw6bRrlBYb6rVzjqS1Td9Z4ZB8A9R7p7BtpRfX7Mt57iHOfxdK2exDcjSOdqJ5SUbpvhdCygLqM-jinFIkbw6xPBmPBsGc_JqdefVrTn4Noil-S_LzZcWyOfVecxehBbg5A97Oxm5jSObxdwMoABFbKbpCrM8EFRXPgaJJLtDkaAiRXDbDHP57xj8PXJmu</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>67993355</pqid></control><display><type>article</type><title>Assessing the efficacy of within-animal control strategies against E. coli O157: A simulation study</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Wood, J.C. ; McKendrick, I.J. ; Gettinby, G.</creator><creatorcontrib>Wood, J.C. ; McKendrick, I.J. ; Gettinby, G.</creatorcontrib><description>A stochastic simulation model was used to assess the efficacy of potential measures to control the levels of
Escherichia coli O157 within the bovine host. The model described
E. coli O157 population sizes at several sites along the bovine gut and therefore only interventions that operate at an individual animal level could be evaluated. In order to use the model to evaluate the control strategies, it was necessary to make assumptions about how each strategy affected
E. coli O157 populations in vivo. The within-animal conditions under these control strategies were modelled by adjusting the growth rates of
E. coli O157 at specific sites of interest in the gut, based on these assumptions. The model simulated the population dynamics of an initial dose of
E. coli O157 inoculated into an animal in the presence of inhibitory probiotics or antibiotics, bactericidal antibiotics or probiotics, and following fasting. Of the control strategies considered, the use of inhibitory probiotics appeared most promising and continued development of a suitable product is to be encouraged.</description><identifier>ISSN: 0167-5877</identifier><identifier>EISSN: 1873-1716</identifier><identifier>DOI: 10.1016/j.prevetmed.2005.11.010</identifier><identifier>PMID: 16464511</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Anti-Bacterial Agents - therapeutic use ; antibiotics ; bacterial colonization ; Cattle ; cattle diseases ; Cattle Diseases - microbiology ; Cattle Diseases - prevention & control ; Cattle Diseases - therapy ; Computer Simulation ; Control strategies ; Diarrhea - microbiology ; Diarrhea - prevention & control ; Diarrhea - therapy ; Diarrhea - veterinary ; Diet - veterinary ; digestive system diseases ; disease control ; disease models ; disease reservoirs ; Edible Grain ; epidemiological studies ; Escherichia coli O157 ; Escherichia coli O157 - growth & development ; Escherichia coli O157 - pathogenicity ; Escherichia coli O157:H7 ; Escherichia infections ; fasting ; Fasting - physiology ; gastrointestinal system ; Gastrointestinal tract ; hosts ; inhibitors ; life cycle (organisms) ; microbial growth ; Models, Biological ; population dynamics ; probiotics ; Probiotics - therapeutic use ; simulation models ; Stochastic Processes</subject><ispartof>Preventive veterinary medicine, 2006-05, Vol.74 (2), p.194-211</ispartof><rights>2005 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-4126195e11007002d6fc0af0b87c2673be97ccce5aa298a3c1ef20e9fc61445f3</citedby><cites>FETCH-LOGICAL-c393t-4126195e11007002d6fc0af0b87c2673be97ccce5aa298a3c1ef20e9fc61445f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.prevetmed.2005.11.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16464511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wood, J.C.</creatorcontrib><creatorcontrib>McKendrick, I.J.</creatorcontrib><creatorcontrib>Gettinby, G.</creatorcontrib><title>Assessing the efficacy of within-animal control strategies against E. coli O157: A simulation study</title><title>Preventive veterinary medicine</title><addtitle>Prev Vet Med</addtitle><description>A stochastic simulation model was used to assess the efficacy of potential measures to control the levels of
Escherichia coli O157 within the bovine host. The model described
E. coli O157 population sizes at several sites along the bovine gut and therefore only interventions that operate at an individual animal level could be evaluated. In order to use the model to evaluate the control strategies, it was necessary to make assumptions about how each strategy affected
E. coli O157 populations in vivo. The within-animal conditions under these control strategies were modelled by adjusting the growth rates of
E. coli O157 at specific sites of interest in the gut, based on these assumptions. The model simulated the population dynamics of an initial dose of
E. coli O157 inoculated into an animal in the presence of inhibitory probiotics or antibiotics, bactericidal antibiotics or probiotics, and following fasting. Of the control strategies considered, the use of inhibitory probiotics appeared most promising and continued development of a suitable product is to be encouraged.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>antibiotics</subject><subject>bacterial colonization</subject><subject>Cattle</subject><subject>cattle diseases</subject><subject>Cattle Diseases - microbiology</subject><subject>Cattle Diseases - prevention & control</subject><subject>Cattle Diseases - therapy</subject><subject>Computer Simulation</subject><subject>Control strategies</subject><subject>Diarrhea - microbiology</subject><subject>Diarrhea - prevention & control</subject><subject>Diarrhea - therapy</subject><subject>Diarrhea - veterinary</subject><subject>Diet - veterinary</subject><subject>digestive system diseases</subject><subject>disease control</subject><subject>disease models</subject><subject>disease reservoirs</subject><subject>Edible Grain</subject><subject>epidemiological studies</subject><subject>Escherichia coli O157</subject><subject>Escherichia coli O157 - growth & development</subject><subject>Escherichia coli O157 - pathogenicity</subject><subject>Escherichia coli O157:H7</subject><subject>Escherichia infections</subject><subject>fasting</subject><subject>Fasting - physiology</subject><subject>gastrointestinal system</subject><subject>Gastrointestinal tract</subject><subject>hosts</subject><subject>inhibitors</subject><subject>life cycle (organisms)</subject><subject>microbial growth</subject><subject>Models, Biological</subject><subject>population dynamics</subject><subject>probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>simulation models</subject><subject>Stochastic Processes</subject><issn>0167-5877</issn><issn>1873-1716</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1v2zAQhomiReOm_QsNp25S70SRlLoZQfoBBMjQZiZo6ujQkCWXpBL435eGjaydbrjnvY-HsRuEGgHV1119iPRMeU9D3QDIGrEGhDdshZ0WFWpUb9mqkLqSndZX7ENKOwBQqpPv2RWqVrUSccXcOiVKKUxbnp-Ik_fBWXfks-cvIT-FqbJT2NuRu3nKcR55ytFm2gZK3G5tmFLmd3XpjoE_oNTf-JqnsF9Gm8M8FXoZjh_ZO2_HRJ8u9Zo9fr_7c_uzun_48et2fV850Ytctdgo7CUhAmiAZlDegfWw6bRrlBYb6rVzjqS1Td9Z4ZB8A9R7p7BtpRfX7Mt57iHOfxdK2exDcjSOdqJ5SUbpvhdCygLqM-jinFIkbw6xPBmPBsGc_JqdefVrTn4Noil-S_LzZcWyOfVecxehBbg5A97Oxm5jSObxdwMoABFbKbpCrM8EFRXPgaJJLtDkaAiRXDbDHP57xj8PXJmu</recordid><startdate>20060517</startdate><enddate>20060517</enddate><creator>Wood, J.C.</creator><creator>McKendrick, I.J.</creator><creator>Gettinby, G.</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20060517</creationdate><title>Assessing the efficacy of within-animal control strategies against E. coli O157: A simulation study</title><author>Wood, J.C. ; McKendrick, I.J. ; Gettinby, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-4126195e11007002d6fc0af0b87c2673be97ccce5aa298a3c1ef20e9fc61445f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>antibiotics</topic><topic>bacterial colonization</topic><topic>Cattle</topic><topic>cattle diseases</topic><topic>Cattle Diseases - microbiology</topic><topic>Cattle Diseases - prevention & control</topic><topic>Cattle Diseases - therapy</topic><topic>Computer Simulation</topic><topic>Control strategies</topic><topic>Diarrhea - microbiology</topic><topic>Diarrhea - prevention & control</topic><topic>Diarrhea - therapy</topic><topic>Diarrhea - veterinary</topic><topic>Diet - veterinary</topic><topic>digestive system diseases</topic><topic>disease control</topic><topic>disease models</topic><topic>disease reservoirs</topic><topic>Edible Grain</topic><topic>epidemiological studies</topic><topic>Escherichia coli O157</topic><topic>Escherichia coli O157 - growth & development</topic><topic>Escherichia coli O157 - pathogenicity</topic><topic>Escherichia coli O157:H7</topic><topic>Escherichia infections</topic><topic>fasting</topic><topic>Fasting - physiology</topic><topic>gastrointestinal system</topic><topic>Gastrointestinal tract</topic><topic>hosts</topic><topic>inhibitors</topic><topic>life cycle (organisms)</topic><topic>microbial growth</topic><topic>Models, Biological</topic><topic>population dynamics</topic><topic>probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>simulation models</topic><topic>Stochastic Processes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wood, J.C.</creatorcontrib><creatorcontrib>McKendrick, I.J.</creatorcontrib><creatorcontrib>Gettinby, G.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Preventive veterinary medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wood, J.C.</au><au>McKendrick, I.J.</au><au>Gettinby, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the efficacy of within-animal control strategies against E. coli O157: A simulation study</atitle><jtitle>Preventive veterinary medicine</jtitle><addtitle>Prev Vet Med</addtitle><date>2006-05-17</date><risdate>2006</risdate><volume>74</volume><issue>2</issue><spage>194</spage><epage>211</epage><pages>194-211</pages><issn>0167-5877</issn><eissn>1873-1716</eissn><abstract>A stochastic simulation model was used to assess the efficacy of potential measures to control the levels of
Escherichia coli O157 within the bovine host. The model described
E. coli O157 population sizes at several sites along the bovine gut and therefore only interventions that operate at an individual animal level could be evaluated. In order to use the model to evaluate the control strategies, it was necessary to make assumptions about how each strategy affected
E. coli O157 populations in vivo. The within-animal conditions under these control strategies were modelled by adjusting the growth rates of
E. coli O157 at specific sites of interest in the gut, based on these assumptions. The model simulated the population dynamics of an initial dose of
E. coli O157 inoculated into an animal in the presence of inhibitory probiotics or antibiotics, bactericidal antibiotics or probiotics, and following fasting. Of the control strategies considered, the use of inhibitory probiotics appeared most promising and continued development of a suitable product is to be encouraged.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>16464511</pmid><doi>10.1016/j.prevetmed.2005.11.010</doi><tpages>18</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-5877 |
| ispartof | Preventive veterinary medicine, 2006-05, Vol.74 (2), p.194-211 |
| issn | 0167-5877 1873-1716 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67993355 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Anti-Bacterial Agents - therapeutic use antibiotics bacterial colonization Cattle cattle diseases Cattle Diseases - microbiology Cattle Diseases - prevention & control Cattle Diseases - therapy Computer Simulation Control strategies Diarrhea - microbiology Diarrhea - prevention & control Diarrhea - therapy Diarrhea - veterinary Diet - veterinary digestive system diseases disease control disease models disease reservoirs Edible Grain epidemiological studies Escherichia coli O157 Escherichia coli O157 - growth & development Escherichia coli O157 - pathogenicity Escherichia coli O157:H7 Escherichia infections fasting Fasting - physiology gastrointestinal system Gastrointestinal tract hosts inhibitors life cycle (organisms) microbial growth Models, Biological population dynamics probiotics Probiotics - therapeutic use simulation models Stochastic Processes |
| title | Assessing the efficacy of within-animal control strategies against E. coli O157: A simulation study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T13%3A52%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessing%20the%20efficacy%20of%20within-animal%20control%20strategies%20against%20E.%20coli%20O157:%20A%20simulation%20study&rft.jtitle=Preventive%20veterinary%20medicine&rft.au=Wood,%20J.C.&rft.date=2006-05-17&rft.volume=74&rft.issue=2&rft.spage=194&rft.epage=211&rft.pages=194-211&rft.issn=0167-5877&rft.eissn=1873-1716&rft_id=info:doi/10.1016/j.prevetmed.2005.11.010&rft_dat=%3Cproquest_cross%3E67993355%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=67993355&rft_id=info:pmid/16464511&rft_els_id=S0167587705003351&rfr_iscdi=true |