Large-Scale Preparation of Human Anti—Third-Party Veto Cytotoxic T Lymphocytes Depleted of Graft-Versus-Host Reactivity: A New Source for Graft Facilitating Cells in Bone Marrow Transplantation

Induction of donor type chimerism in mildly prepared hosts without graft-versus-host disease (GvHD) is a most desirable goal in bone morrow transplantation. We have recently demonstrated in a mouse model that donor veto cytotoxic T lymphocytes (CTLs) can facilitate the induction of donor type chimer...

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Veröffentlicht in:	Human Immunology 2005-06, Vol.66 (6), p.644-652
Hauptverfasser:	Aviner, Shraga, Yao, Xin, Krauthgamer, Rita, Gan, Yehudit, Goren-Arbel, Rinat, Klein, Tirza, Tabilio, Antonio, McMannis, John D., Champlin, Richard, Martelli, Massimo F., Bachar-Lustig, Esther, Reisner, Yair
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Marrow Transplantation - immunology Clone Cells cytotoxic lymphocytes Graft vs Host Disease - immunology Graft vs Host Disease - prevention & control GvHD Humans Immune Tolerance - immunology Lymphocyte Activation - immunology Lymphocyte Culture Test, Mixed Lymphocyte Depletion - methods T-Lymphocytes, Cytotoxic - immunology Tissue Donors
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