Adhesion- and Degranulation-Promoting Adapter Protein Is Required for Efficient Thymocyte Development and Selection

Adhesion- and degranulation-promoting adapter protein (ADAP) is required in TCR-induced activation and proliferation of peripheral T cells. Loss of ADAP also impairs TCR-initiated inside-out activation of the integrin LFA-1 (CD11a/CD18, alphaLbeta2). In this study, we demonstrate that ADAP-deficient...

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Veröffentlicht in:	Journal of Immunology 2006-06, Vol.176 (11), p.6681-6689
Hauptverfasser:	Wu, Jennifer N, Gheith, Shereen, Bezman, Natalie A, Liu, Qing-Hua, Fostel, Lindsey V, Swanson, Andrew M, Freedman, Bruce D, Koretzky, Gary A, Peterson, Erik J
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - physiology Amino Acid Sequence Animals Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Calcium - metabolism CD4 Antigens - biosynthesis CD8 Antigens - biosynthesis Cell Adhesion - genetics Cell Adhesion - immunology Cell Degranulation - genetics Cell Degranulation - immunology Cell Differentiation - genetics Cell Differentiation - immunology Cell Line, Tumor Cell Proliferation Female Lymphocyte Count Male Mice Mice, Knockout Mice, Transgenic Molecular Sequence Data T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Thymus Gland - cytology Thymus Gland - immunology Thymus Gland - metabolism
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