Targeted deletion of p53 prevents cardiac rupture after myocardial infarction in mice

Apoptosis may play an important role in cardiac remodeling after myocardial infarction (MI). p53 is a well-known proapoptotic factor. However, its pathophysiological significance in these conditions remains unclear. We thus examined the effects of target deletion of the p53 gene on post-MI hearts. A...

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Veröffentlicht in:	Cardiovascular research 2006-06, Vol.70 (3), p.457-465
Hauptverfasser:	Matsusaka, Hidenori, Ide, Tomomi, Matsushima, Shouji, Ikeuchi, Masaki, Kubota, Toru, Sunagawa, Kenji, Kinugawa, Shintaro, Tsutsui, Hiroyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Echocardiography Female Gene Deletion Heart Rupture, Post-Infarction - metabolism Heart Rupture, Post-Infarction - physiopathology Heart Rupture, Post-Infarction - prevention & control Heterozygote Male Matrix Metalloproteinases - metabolism Mice Mice, Inbred C57BL Mice, Knockout Models, Animal Myocardial Infarction - diagnostic imaging Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Oncogene Protein v-akt - metabolism Time Factors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - physiopathology Ventricular Remodeling
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