Lipoprotein-associated phospholipase A2 as a target of therapy

Considerable discussion continues regarding the precise role that secreted lipoprotein-associated phospholipase A2 (Lp-PLA2), also called platelet-activating factor acetylhydrolase, plays in atherosclerosis. Since interest in this enzyme as a putative drug target has been based primarily upon its as...

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Veröffentlicht in:	Current opinion in lipidology 2005-08, Vol.16 (4), p.442-446
Hauptverfasser:	Macphee, Colin H, Nelson, Jeanenne J, Zalewski, Andrew
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Alkyl-2-acetylglycerophosphocholine Esterase Cardiovascular Diseases - drug therapy Cardiovascular Diseases - enzymology Cardiovascular Diseases - etiology Humans Lovastatin - therapeutic use Macrophages - enzymology Phospholipases A - antagonists & inhibitors Phospholipases A - genetics Phospholipases A - metabolism Phospholipases A2
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