Increased prevalence of high Body Mass Index in patients presenting with pituitary tumours: severe obesity in patients with macroprolactinoma
Prolactinoma has been associated with obesity. As opposed to ACTH- and GH-secreting adenoma, the mechanism by which macroprolactinoma causes obesity has not been fully understood. Having seen patients with both prolactinoma and obesity and more recent literature on brain dopamine, dopamine 2 recepto...
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| Veröffentlicht in: | Swiss medical weekly 2006-04, Vol.136 (15-16), p.254-258 |
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| creator | Schmid, Christoph Goede, Diane L Hauser, Renward S Brändle, Michael |
| description | Prolactinoma has been associated with obesity. As opposed to ACTH- and GH-secreting adenoma, the mechanism by which macroprolactinoma causes obesity has not been fully understood. Having seen patients with both prolactinoma and obesity and more recent literature on brain dopamine, dopamine 2 receptors and obesity, we re-evaluated the potential relationship between prolactinoma and obesity.
Data of patients with pituitary adenomas were collected retrospectively over a period of 20 years. 399 patients with well-documented pituitary adenomas and information about pre-treatment body mass index (BMI), age, sex, and tumour type were analysed.
Elevated BMI (> or = 30 kg/m2) was observed in 8/36 patients (22.2%) with ACTH-producing tumours, in 15/70 (21.4%) with GH-producing tumours, in 25/100 (25%) with macroprolactinoma, in 8/81 (9.9%) with microprolactinoma, and in 18/105 (17.1%) with inactive macroadenomas. Macroprolactinoma patients had a mean BMI value (27.5 +/- 7.7 kg/m2) similar to that of patients with Cushing's disease (27.2 +/- 5.9 kg/m2) and acromegaly (27.4 +/- 4.4 kg/m2) and on average a significantly higher BMI value compared to that of patients with inactive macroadenomas (25.8 +/- 4.4 kg/m2) (95% CI 1.2, 4.4; p-value or = 30 kg/m2 in patients with macroprolactinoma was significantly higher (95% CI 0.1, 0.29; p-value |
| format | Article |
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Data of patients with pituitary adenomas were collected retrospectively over a period of 20 years. 399 patients with well-documented pituitary adenomas and information about pre-treatment body mass index (BMI), age, sex, and tumour type were analysed.
Elevated BMI (> or = 30 kg/m2) was observed in 8/36 patients (22.2%) with ACTH-producing tumours, in 15/70 (21.4%) with GH-producing tumours, in 25/100 (25%) with macroprolactinoma, in 8/81 (9.9%) with microprolactinoma, and in 18/105 (17.1%) with inactive macroadenomas. Macroprolactinoma patients had a mean BMI value (27.5 +/- 7.7 kg/m2) similar to that of patients with Cushing's disease (27.2 +/- 5.9 kg/m2) and acromegaly (27.4 +/- 4.4 kg/m2) and on average a significantly higher BMI value compared to that of patients with inactive macroadenomas (25.8 +/- 4.4 kg/m2) (95% CI 1.2, 4.4; p-value <0.001). Compared to the general population, the proportion of BMI > or = 30 kg/m2 in patients with macroprolactinoma was significantly higher (95% CI 0.1, 0.29; p-value <0.001).
Average BMI in macroprolactinoma patients is significantly higher than BMI in patients with inactive adenomas. Macroprolactinoma is associated with increased frequency of obesity compared to the general population. We propose that in a subgroup of individuals obesity and macroprolactinoma may share a common basis, namely decreased dopamine 2 receptor-mediated actions.</description><identifier>ISSN: 1424-7860</identifier><identifier>PMID: 16708311</identifier><language>eng</language><publisher>Switzerland</publisher><subject>ACTH-Secreting Pituitary Adenoma - complications ; Adolescent ; Adult ; Body Mass Index ; Female ; Growth Hormone-Secreting Pituitary Adenoma - complications ; Humans ; Male ; Middle Aged ; Obesity - etiology ; Pituitary Neoplasms - complications ; Pituitary Neoplasms - pathology ; Prolactinoma - complications ; Prolactinoma - pathology ; Retrospective Studies</subject><ispartof>Swiss medical weekly, 2006-04, Vol.136 (15-16), p.254-258</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16708311$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schmid, Christoph</creatorcontrib><creatorcontrib>Goede, Diane L</creatorcontrib><creatorcontrib>Hauser, Renward S</creatorcontrib><creatorcontrib>Brändle, Michael</creatorcontrib><title>Increased prevalence of high Body Mass Index in patients presenting with pituitary tumours: severe obesity in patients with macroprolactinoma</title><title>Swiss medical weekly</title><addtitle>Swiss Med Wkly</addtitle><description>Prolactinoma has been associated with obesity. As opposed to ACTH- and GH-secreting adenoma, the mechanism by which macroprolactinoma causes obesity has not been fully understood. Having seen patients with both prolactinoma and obesity and more recent literature on brain dopamine, dopamine 2 receptors and obesity, we re-evaluated the potential relationship between prolactinoma and obesity.
Data of patients with pituitary adenomas were collected retrospectively over a period of 20 years. 399 patients with well-documented pituitary adenomas and information about pre-treatment body mass index (BMI), age, sex, and tumour type were analysed.
Elevated BMI (> or = 30 kg/m2) was observed in 8/36 patients (22.2%) with ACTH-producing tumours, in 15/70 (21.4%) with GH-producing tumours, in 25/100 (25%) with macroprolactinoma, in 8/81 (9.9%) with microprolactinoma, and in 18/105 (17.1%) with inactive macroadenomas. Macroprolactinoma patients had a mean BMI value (27.5 +/- 7.7 kg/m2) similar to that of patients with Cushing's disease (27.2 +/- 5.9 kg/m2) and acromegaly (27.4 +/- 4.4 kg/m2) and on average a significantly higher BMI value compared to that of patients with inactive macroadenomas (25.8 +/- 4.4 kg/m2) (95% CI 1.2, 4.4; p-value <0.001). Compared to the general population, the proportion of BMI > or = 30 kg/m2 in patients with macroprolactinoma was significantly higher (95% CI 0.1, 0.29; p-value <0.001).
Average BMI in macroprolactinoma patients is significantly higher than BMI in patients with inactive adenomas. Macroprolactinoma is associated with increased frequency of obesity compared to the general population. We propose that in a subgroup of individuals obesity and macroprolactinoma may share a common basis, namely decreased dopamine 2 receptor-mediated actions.</description><subject>ACTH-Secreting Pituitary Adenoma - complications</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Body Mass Index</subject><subject>Female</subject><subject>Growth Hormone-Secreting Pituitary Adenoma - complications</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity - etiology</subject><subject>Pituitary Neoplasms - complications</subject><subject>Pituitary Neoplasms - pathology</subject><subject>Prolactinoma - complications</subject><subject>Prolactinoma - pathology</subject><subject>Retrospective Studies</subject><issn>1424-7860</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkMtOwzAQRb0A0VL4BeQVu0h2nIfNDioelYrYwDpynHFrlNjBdgr9CP4ZA2XBamZx7hnNPUJzWuRFVvOKzNBpCK-E5Lyi5Qma0aomnFE6R58rqzzIAB0ePexkD1YBdhpvzWaLb1y3x48yBLyyHXxgY_EoowEbwzce0mLsBr-buMWjiZOJ0u9xnAY3-XCFA-zAJ1sLwcT9v_RPZJDKu9G7XqrkcYM8Q8da9gHOD3OBXu5un5cP2frpfrW8XmdjTkTM6pJyWha8kEJTzajIdcuVUKyivAZWC6V0x6koCQcqoexYoVpSUUkSV5aaLdDlrzcdf5sgxGYwQUHfSwtuCk1VC0EZyxN4cQCndoCuGb0Z0ovNX4HsC9zTbxc</recordid><startdate>20060415</startdate><enddate>20060415</enddate><creator>Schmid, Christoph</creator><creator>Goede, Diane L</creator><creator>Hauser, Renward S</creator><creator>Brändle, Michael</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20060415</creationdate><title>Increased prevalence of high Body Mass Index in patients presenting with pituitary tumours: severe obesity in patients with macroprolactinoma</title><author>Schmid, Christoph ; Goede, Diane L ; Hauser, Renward S ; Brändle, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-751815484a9f1f3192fb8c9c36187e379ccfd819508e1ae5d34cb061a0fb855f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>ACTH-Secreting Pituitary Adenoma - complications</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Body Mass Index</topic><topic>Female</topic><topic>Growth Hormone-Secreting Pituitary Adenoma - complications</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity - etiology</topic><topic>Pituitary Neoplasms - complications</topic><topic>Pituitary Neoplasms - pathology</topic><topic>Prolactinoma - complications</topic><topic>Prolactinoma - pathology</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schmid, Christoph</creatorcontrib><creatorcontrib>Goede, Diane L</creatorcontrib><creatorcontrib>Hauser, Renward S</creatorcontrib><creatorcontrib>Brändle, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Swiss medical weekly</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schmid, Christoph</au><au>Goede, Diane L</au><au>Hauser, Renward S</au><au>Brändle, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased prevalence of high Body Mass Index in patients presenting with pituitary tumours: severe obesity in patients with macroprolactinoma</atitle><jtitle>Swiss medical weekly</jtitle><addtitle>Swiss Med Wkly</addtitle><date>2006-04-15</date><risdate>2006</risdate><volume>136</volume><issue>15-16</issue><spage>254</spage><epage>258</epage><pages>254-258</pages><issn>1424-7860</issn><abstract>Prolactinoma has been associated with obesity. As opposed to ACTH- and GH-secreting adenoma, the mechanism by which macroprolactinoma causes obesity has not been fully understood. Having seen patients with both prolactinoma and obesity and more recent literature on brain dopamine, dopamine 2 receptors and obesity, we re-evaluated the potential relationship between prolactinoma and obesity.
Data of patients with pituitary adenomas were collected retrospectively over a period of 20 years. 399 patients with well-documented pituitary adenomas and information about pre-treatment body mass index (BMI), age, sex, and tumour type were analysed.
Elevated BMI (> or = 30 kg/m2) was observed in 8/36 patients (22.2%) with ACTH-producing tumours, in 15/70 (21.4%) with GH-producing tumours, in 25/100 (25%) with macroprolactinoma, in 8/81 (9.9%) with microprolactinoma, and in 18/105 (17.1%) with inactive macroadenomas. Macroprolactinoma patients had a mean BMI value (27.5 +/- 7.7 kg/m2) similar to that of patients with Cushing's disease (27.2 +/- 5.9 kg/m2) and acromegaly (27.4 +/- 4.4 kg/m2) and on average a significantly higher BMI value compared to that of patients with inactive macroadenomas (25.8 +/- 4.4 kg/m2) (95% CI 1.2, 4.4; p-value <0.001). Compared to the general population, the proportion of BMI > or = 30 kg/m2 in patients with macroprolactinoma was significantly higher (95% CI 0.1, 0.29; p-value <0.001).
Average BMI in macroprolactinoma patients is significantly higher than BMI in patients with inactive adenomas. Macroprolactinoma is associated with increased frequency of obesity compared to the general population. We propose that in a subgroup of individuals obesity and macroprolactinoma may share a common basis, namely decreased dopamine 2 receptor-mediated actions.</abstract><cop>Switzerland</cop><pmid>16708311</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Swiss medical weekly, 2006-04, Vol.136 (15-16), p.254-258 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Alma/SFX Local Collection |
| subjects | ACTH-Secreting Pituitary Adenoma - complications Adolescent Adult Body Mass Index Female Growth Hormone-Secreting Pituitary Adenoma - complications Humans Male Middle Aged Obesity - etiology Pituitary Neoplasms - complications Pituitary Neoplasms - pathology Prolactinoma - complications Prolactinoma - pathology Retrospective Studies |
| title | Increased prevalence of high Body Mass Index in patients presenting with pituitary tumours: severe obesity in patients with macroprolactinoma |
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