A single nucleotide polymorphism in the MDM2 gene : From a molecular and cellular explanation to clinical effect
In a recent article, a candidate pathway approach was taken to try to identify single nucleotide polymorphisms (SNP) that make up the genetic variation, which underlies the phenotypic variation seen between individuals in their susceptibility to cancer and the progression of their disease. The p53 s...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 2005-07, Vol.65 (13), p.5481-5484 |
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| container_issue | 13 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | BOND, Gareth L WENWEI HU LEVINE, Arnold |
| description | In a recent article, a candidate pathway approach was taken to try to identify single nucleotide polymorphisms (SNP) that make up the genetic variation, which underlies the phenotypic variation seen between individuals in their susceptibility to cancer and the progression of their disease. The p53 stress response pathway was chosen given its well-documented importance in tumor suppression. A SNP was found which associates with the attenuation of the p53 pathway and the acceleration of tumor formation in humans and data was presented which describe a molecular mechanism for these phenotypes. |
| doi_str_mv | 10.1158/0008-5472.CAN-05-0825 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0008-5472 |
| ispartof | Cancer research (Chicago, Ill.), 2005-07, Vol.65 (13), p.5481-5484 |
| issn | 0008-5472 1538-7445 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_67990263 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; American Association for Cancer Research |
| subjects | Animals Antineoplastic agents Biological and medical sciences Genetic Predisposition to Disease Humans Medical sciences Neoplasms - genetics Nuclear Proteins - genetics Pharmacology. Drug treatments Polymorphism, Single Nucleotide Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins c-mdm2 Tumors |
| title | A single nucleotide polymorphism in the MDM2 gene : From a molecular and cellular explanation to clinical effect |
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