Inducible regulation of Runx2-stimulated osteogenesis

Ex vivo gene therapy is a promising approach to orthopedic regenerative medicine. These strategies typically focus on the constitutive overexpression of osteogenic factors to induce osteoblastic differentiation and matrix mineralization. However, the unregulated production of osteoinductive molecule...

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Veröffentlicht in:	Gene therapy 2006-06, Vol.13 (11), p.873-882
Hauptverfasser:	Gersbach, C A, Le Doux, J M, Guldberg, R E, García, A J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline phosphatase Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Anti-Bacterial Agents Applied cell therapy and gene therapy Biological and medical sciences Biomedical and Life Sciences Biomedicine Biotechnology Bone diseases Bone growth Bone Transplantation Bones Care and treatment Cbfa-1 protein Cell Biology Cell culture Cells Cells, Cultured Collagen Computed tomography Core Binding Factor Alpha 1 Subunit - genetics Core Binding Factor Alpha 1 Subunit - metabolism Culture media DNA binding proteins Drinking water Fundamental and applied biological sciences. Psychology Gene Expression Gene Expression Regulation Gene Therapy Genetic aspects Genetic Therapy - methods Genetic Vectors - administration & dosage Growth Health aspects Health. Pharmaceutical industry Hindlimb Human Genetics Industrial applications and implications. Economical aspects Male Medical sciences Mice Mice, Inbred BALB C Mineralization Myoblasts Nanotechnology original-article Orthopedics Osteoblastogenesis Osteoblasts Osteoblasts - cytology Osteoblasts - diagnostic imaging Osteoblasts - metabolism Osteogenesis Physiological aspects Regenerative medicine Retroviridae - genetics Tetracycline Tissue engineering Tissue Engineering - methods Tomography, X-Ray Computed Trans-Activators Transduction, Genetic - methods Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumorigenesis
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