Synthesis and biological properties of new chimeric galanin analogue GAL(1-13)-[Ala10,11]ET-1(6-21)-NH2

Several chimeric peptides consisting of the N-terminal fragment of galanin (GAL) and C-terminal fragments of other bioactive peptides (e.g. substance P, bradykinin, neuropeptide Y, mastoparan) have been synthesized and reported as high-affinity galanin receptor antagonists. Recently we have synthesi...

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Veröffentlicht in:	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2005-06, Vol.56 (2), p.273-285
Hauptverfasser:	Ruczyński, J, Konstański, Z, Cybal, M, Petrusewicz, J, Wójcikowski, C, Rekowski, P, Kamińska, B
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Galanin - analogs & derivatives Galanin - chemical synthesis Galanin - pharmacology In Vitro Techniques Insulin - metabolism Insulin Secretion Male Molecular Sequence Data Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - physiology Rats Rats, Wistar Receptors, Galanin - antagonists & inhibitors Recombinant Fusion Proteins - chemical synthesis Recombinant Fusion Proteins - pharmacology Stomach - drug effects Stomach - physiology
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