ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5
We present an evaluation of the results of our ZDOCK and RDOCK algorithms in Rounds 3, 4, and 5 of the protein docking challenge CAPRI. ZDOCK is a Fast Fourier Transform (FFT)‐based, initial‐stage rigid‐body docking algorithm, and RDOCK is an energy minimization algorithm for refining and reranking...
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| Veröffentlicht in: | Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2005-08, Vol.60 (2), p.207-213 |
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| container_title | Proteins, structure, function, and bioinformatics |
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| creator | Wiehe, Kevin Pierce, Brian Mintseris, Julian Tong, Wei Wei Anderson, Robert Chen, Rong Weng, Zhiping |
| description | We present an evaluation of the results of our ZDOCK and RDOCK algorithms in Rounds 3, 4, and 5 of the protein docking challenge CAPRI. ZDOCK is a Fast Fourier Transform (FFT)‐based, initial‐stage rigid‐body docking algorithm, and RDOCK is an energy minimization algorithm for refining and reranking ZDOCK results. Of the 9 targets for which we submitted predictions, we attained at least acceptable accuracy for 7, at least medium accuracy for 6, and high accuracy for 3. These results are evidence that ZDOCK in combination with RDOCK is capable of making accurate predictions on a diverse set of protein complexes. Proteins 2005;60:207–213. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/prot.20559 |
| format | Article |
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| ispartof | Proteins, structure, function, and bioinformatics, 2005-08, Vol.60 (2), p.207-213 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Algorithms Animals Binding Sites blind test CAPRI Cluster Analysis Computational Biology - methods Computer Simulation Databases, Protein Dimerization Humans Internet Macromolecular Substances Models, Molecular Models, Statistical Molecular Conformation Protein Conformation protein docking Protein Folding Protein Interaction Mapping - methods Protein Structure, Tertiary Proteomics - methods RDOCK Reproducibility of Results scoring function Software Structural Homology, Protein ZDOCK |
| title | ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5 |
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