Tuning the Regioselectivity of the Staudinger Reaction for the Facile Synthesis of Kanamycin and Neomycin Class Antibiotics with N-1 Modification

A novel method for achieving the desired regioselective reduction of the N-1 azido group on a tetraazidoneamine has been developed that leads to the synthesis of both kanamycin and neomycin class antibiotics bearing N-1 modification. Both classes of aminoglycosides are active against aminoglycoside-...

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Veröffentlicht in:	Organic letters 2005-07, Vol.7 (14), p.3061-3064
Hauptverfasser:	Li, Jie, Chen, Hsiao-Nung, Chang, Huiwen, Wang, Jinhua, Chang, Cheng-Wei Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Amikacin - pharmacology Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - classification Drug Resistance, Microbial Escherichia coli - drug effects Kanamycin - analogs & derivatives Kanamycin - chemical synthesis Kanamycin - chemistry Microbial Sensitivity Tests Molecular Structure Neomycin - chemical synthesis Neomycin - chemistry Stereoisomerism Structure-Activity Relationship
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