Metabotropic glutamate receptor subtype 7 ablation causes dysregulation of the HPA axis and increases hippocampal BDNF protein levels : Implications for stress-related psychiatric disorders

Regulation of neurotransmission via group-III metabotropic glutamate receptors (mGluR4, -6, -7, and -8) has recently been implicated in the pathophysiology of affective disorders, such as major depression and anxiety. For instance, mice with a targeted deletion of the gene for mGluR7 (mGluR7-/-) sho...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2006-06, Vol.31 (6), p.1112-1122
Hauptverfasser:	MITSUKAWA, Kayo, MOMBEREAU, Cedric, LÖTSCHER, Erika, UZUNOV, Doncho P, VAN DER PUTTEN, Herman, FLOR, Peter J, CRYAN, John F
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenocorticotropic Hormone - blood Adult and adolescent clinical studies Animals Biological and medical sciences Body Weight - drug effects Body Weight - genetics Brain-Derived Neurotrophic Factor - genetics Brain-Derived Neurotrophic Factor - metabolism Depression Dexamethasone - pharmacology Gene Expression Regulation - drug effects Gene Expression Regulation - physiology Glucocorticoids - pharmacology Hippocampus - drug effects Hippocampus - metabolism Hypothalamo-Hypophyseal System - drug effects Hypothalamo-Hypophyseal System - metabolism Immunoassay - methods Male Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Mood disorders Pituitary-Adrenal System - drug effects Pituitary-Adrenal System - metabolism Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radioimmunoassay - methods Receptor, Serotonin, 5-HT1A - genetics Receptor, Serotonin, 5-HT1A - metabolism Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism Receptors, Metabotropic Glutamate - deficiency Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - metabolism Stress, Physiological - metabolism
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