Maspin alters the carcinoma proteome

ABSTRACTMaspin, a member of the serine protease inhibitor (serpin) family, is a tumor suppressor in breast and prostate cancer. To address molecular mechanisms underlying maspin's activity, we restored its expression in invasive carcinoma cells and analyzed the resulting changes by shotgun prot...

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Veröffentlicht in:	The FASEB journal 2005-07, Vol.19 (9), p.1123-1124
Hauptverfasser:	Chen, Emily I, Florens, Laurence, Axelrod, Fumiko T, Monosov, Edward, Barbas, Carlos F, Yates, John R, Felding-Habermann, Brunhilde, Smith, Jeffrey W
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Breast Neoplasms - genetics Breast Neoplasms - pathology cancer proteomics Cell Line, Tumor Female Genes, Tumor Suppressor - physiology Humans metastasis MudPIT Neoplasm Metastasis - genetics Neoplasm Metastasis - prevention & control Proteasome Endopeptidase Complex - physiology protein profiling Proteome Serpins - genetics Serpins - physiology Transfection tumor suppressor Ubiquitin - metabolism
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