Tight junction protein claudin-1 enhances the invasive activity of oral squamous cell carcinoma cells by promoting cleavage of laminin-5 gamma2 chain via matrix metalloproteinase (MMP)-2 and membrane-type MMP-1

Although adherent junctions have been extensively studied, the role of tight junctions in cancer cell invasion is not sufficiently explored. We investigated whether claudin-1, a component of tight junctions, regulated invasion activity in oral squamous cell carcinoma (OSC) cells. The expression of c...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-05, Vol.66 (10), p.5251-5257
Hauptverfasser:	Oku, Naohisa, Sasabe, Eri, Ueta, Eisaku, Yamamoto, Tetsuya, Osaki, Tokio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Line, Tumor Claudin-1 Claudin-4 Humans Immunohistochemistry Laminin - metabolism Male Matrix Metalloproteinase 14 Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinases - metabolism Matrix Metalloproteinases, Membrane-Associated Membrane Proteins - biosynthesis Membrane Proteins - genetics Mice Mice, SCID Mouth Neoplasms - genetics Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Neoplasm Invasiveness Neoplasm Transplantation Occludin RNA, Small Interfering - genetics Snail Family Transcription Factors Tongue Neoplasms - genetics Tongue Neoplasms - metabolism Tongue Neoplasms - pathology Transcription Factors - biosynthesis Transcription Factors - genetics Transplantation, Heterologous Up-Regulation
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