gammadelta T cells increase with gastric mucosal interleukin (IL)-7, IL-1beta, and Helicobacter pylori urease specific immunoglobulin levels via CCR2 upregulation in Helicobacter pylori gastritis
The purpose of this study was to investigate possible factors that could impact on gammadelta T cell accumulation in the gastric mucosa. Subjects were 22 Helicobacter pylori (H. pylori)-free and 75 H. pylori-infected mucosa biopsies classified into grades I approximately III gastritis as per our pre...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2006-01, Vol.21 (1 Pt 1), p.32-40 |
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| creator | Futagami, Seiji Hiratsuka, Tetsuro Suzuki, Kenji Kusunoki, Masanori Wada, Ken Miyake, Kazumasa Ohashi, Kazushi Shimizu, Masumi Takahashi, Hidemi Gudis, Katya Kato, Shunji Tsukui, Taku Sakamoto, Choitsu |
| description | The purpose of this study was to investigate possible factors that could impact on gammadelta T cell accumulation in the gastric mucosa.
Subjects were 22 Helicobacter pylori (H. pylori)-free and 75 H. pylori-infected mucosa biopsies classified into grades I approximately III gastritis as per our previous study. The number of gammadelta- and 45 RO-positive T cells were determined by immunostaining. Gastric mucosal anti-H. pylori urease specific antibodies and interleukin (IL)-1beta, IL-2, 4, 7, 10 and IL-12 levels were assayed by enzyme-linked immunosorbent assay (ELISA). CC chemokine receptor 2 (CCR2) expression levels, migration, and cytokine production in gammadelta T cells stimulated by H. pylori urease were also evaluated.
The gammadelta T cell count was significantly higher in grade III gastritis which exhibits strong immunoglobulin (Ig)A and IgG responses to H. pylori urease with lymphoid follicles than in other groups. gammadelta T cell count was significantly correlated with IL-1beta and interleukin-7 (IL-7) levels in the gastric mucosa. H. pylori urease immunoreactivity was detected in lamina propria of grade III gastritis, along with many gammadelta T cells. After H. pylori eradication therapy, the gammadelta T cell count in grade III gastritis significantly decreased. H. pylori urease stimulated significant increases in CCR2 expression levels, although to a lesser degree than those induced by IL-7 stimulation in both peripheral and mucosal gammadelta T cells. Interferon (IFN)-gamma and IL-10 production was also stimulated by H. pylori urease in peripheral gammadelta T cells.
Gastric mucosal increases in IL-7 and IL-1beta closely corresponded to the accumulation of gammadelta T cells in gastric mucosa. An association was also seen between gammadelta T cell accumulation and H. pylori urease-specific Ig levels. |
| format | Article |
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Subjects were 22 Helicobacter pylori (H. pylori)-free and 75 H. pylori-infected mucosa biopsies classified into grades I approximately III gastritis as per our previous study. The number of gammadelta- and 45 RO-positive T cells were determined by immunostaining. Gastric mucosal anti-H. pylori urease specific antibodies and interleukin (IL)-1beta, IL-2, 4, 7, 10 and IL-12 levels were assayed by enzyme-linked immunosorbent assay (ELISA). CC chemokine receptor 2 (CCR2) expression levels, migration, and cytokine production in gammadelta T cells stimulated by H. pylori urease were also evaluated.
The gammadelta T cell count was significantly higher in grade III gastritis which exhibits strong immunoglobulin (Ig)A and IgG responses to H. pylori urease with lymphoid follicles than in other groups. gammadelta T cell count was significantly correlated with IL-1beta and interleukin-7 (IL-7) levels in the gastric mucosa. H. pylori urease immunoreactivity was detected in lamina propria of grade III gastritis, along with many gammadelta T cells. After H. pylori eradication therapy, the gammadelta T cell count in grade III gastritis significantly decreased. H. pylori urease stimulated significant increases in CCR2 expression levels, although to a lesser degree than those induced by IL-7 stimulation in both peripheral and mucosal gammadelta T cells. Interferon (IFN)-gamma and IL-10 production was also stimulated by H. pylori urease in peripheral gammadelta T cells.
Gastric mucosal increases in IL-7 and IL-1beta closely corresponded to the accumulation of gammadelta T cells in gastric mucosa. An association was also seen between gammadelta T cell accumulation and H. pylori urease-specific Ig levels.</description><identifier>ISSN: 0815-9319</identifier><identifier>PMID: 16706809</identifier><language>eng</language><publisher>Australia</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anti-Bacterial Agents - therapeutic use ; Anti-Ulcer Agents - therapeutic use ; Cells, Cultured ; Chemotaxis, Leukocyte ; Female ; Gastric Mucosa - immunology ; Gastric Mucosa - microbiology ; Gastric Mucosa - pathology ; Gastritis - drug therapy ; Gastritis - immunology ; Gastritis - microbiology ; Gastritis - pathology ; Helicobacter Infections - drug therapy ; Helicobacter Infections - immunology ; Helicobacter Infections - microbiology ; Helicobacter Infections - pathology ; Helicobacter pylori - enzymology ; Helicobacter pylori - immunology ; Humans ; Immunoglobulin A - biosynthesis ; Immunoglobulin G - biosynthesis ; Interleukin-1beta - biosynthesis ; Interleukin-7 - biosynthesis ; Leukocyte Common Antigens - analysis ; Male ; Middle Aged ; Receptors, Antigen, T-Cell, gamma-delta - analysis ; Receptors, CCR2 ; Receptors, Chemokine - biosynthesis ; T-Lymphocyte Subsets - immunology ; T-Lymphocyte Subsets - microbiology ; Urease - immunology</subject><ispartof>Journal of gastroenterology and hepatology, 2006-01, Vol.21 (1 Pt 1), p.32-40</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16706809$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Futagami, Seiji</creatorcontrib><creatorcontrib>Hiratsuka, Tetsuro</creatorcontrib><creatorcontrib>Suzuki, Kenji</creatorcontrib><creatorcontrib>Kusunoki, Masanori</creatorcontrib><creatorcontrib>Wada, Ken</creatorcontrib><creatorcontrib>Miyake, Kazumasa</creatorcontrib><creatorcontrib>Ohashi, Kazushi</creatorcontrib><creatorcontrib>Shimizu, Masumi</creatorcontrib><creatorcontrib>Takahashi, Hidemi</creatorcontrib><creatorcontrib>Gudis, Katya</creatorcontrib><creatorcontrib>Kato, Shunji</creatorcontrib><creatorcontrib>Tsukui, Taku</creatorcontrib><creatorcontrib>Sakamoto, Choitsu</creatorcontrib><title>gammadelta T cells increase with gastric mucosal interleukin (IL)-7, IL-1beta, and Helicobacter pylori urease specific immunoglobulin levels via CCR2 upregulation in Helicobacter pylori gastritis</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>The purpose of this study was to investigate possible factors that could impact on gammadelta T cell accumulation in the gastric mucosa.
Subjects were 22 Helicobacter pylori (H. pylori)-free and 75 H. pylori-infected mucosa biopsies classified into grades I approximately III gastritis as per our previous study. The number of gammadelta- and 45 RO-positive T cells were determined by immunostaining. Gastric mucosal anti-H. pylori urease specific antibodies and interleukin (IL)-1beta, IL-2, 4, 7, 10 and IL-12 levels were assayed by enzyme-linked immunosorbent assay (ELISA). CC chemokine receptor 2 (CCR2) expression levels, migration, and cytokine production in gammadelta T cells stimulated by H. pylori urease were also evaluated.
The gammadelta T cell count was significantly higher in grade III gastritis which exhibits strong immunoglobulin (Ig)A and IgG responses to H. pylori urease with lymphoid follicles than in other groups. gammadelta T cell count was significantly correlated with IL-1beta and interleukin-7 (IL-7) levels in the gastric mucosa. H. pylori urease immunoreactivity was detected in lamina propria of grade III gastritis, along with many gammadelta T cells. After H. pylori eradication therapy, the gammadelta T cell count in grade III gastritis significantly decreased. H. pylori urease stimulated significant increases in CCR2 expression levels, although to a lesser degree than those induced by IL-7 stimulation in both peripheral and mucosal gammadelta T cells. Interferon (IFN)-gamma and IL-10 production was also stimulated by H. pylori urease in peripheral gammadelta T cells.
Gastric mucosal increases in IL-7 and IL-1beta closely corresponded to the accumulation of gammadelta T cells in gastric mucosa. An association was also seen between gammadelta T cell accumulation and H. pylori urease-specific Ig levels.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Cells, Cultured</subject><subject>Chemotaxis, Leukocyte</subject><subject>Female</subject><subject>Gastric Mucosa - immunology</subject><subject>Gastric Mucosa - microbiology</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastritis - drug therapy</subject><subject>Gastritis - immunology</subject><subject>Gastritis - microbiology</subject><subject>Gastritis - pathology</subject><subject>Helicobacter Infections - drug therapy</subject><subject>Helicobacter Infections - immunology</subject><subject>Helicobacter Infections - microbiology</subject><subject>Helicobacter Infections - pathology</subject><subject>Helicobacter pylori - enzymology</subject><subject>Helicobacter pylori - immunology</subject><subject>Humans</subject><subject>Immunoglobulin A - biosynthesis</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Interleukin-1beta - biosynthesis</subject><subject>Interleukin-7 - biosynthesis</subject><subject>Leukocyte Common Antigens - analysis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Receptors, Antigen, T-Cell, gamma-delta - analysis</subject><subject>Receptors, CCR2</subject><subject>Receptors, Chemokine - biosynthesis</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>T-Lymphocyte Subsets - microbiology</subject><subject>Urease - immunology</subject><issn>0815-9319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFOwzAQRbMA0VK4AvIKgdRIdp3E8RJFQCtVQkLdRxNnHAx2EuK4qOfjYgS17FjNYt68P_pn0ZzmLI0lZ3IWXXr_TilNqEgvohnLBM1yKufRdwPOQY12BLIjCq31xLRqQPBIvsz4Rhrw42AUcUF1Huy0HXGwGD5MS-422_tYLMlmG7MKR1gSaGuyRmtUV4GaQNIfbDcYEo5G36MyerIZ50LbNbargp1EFvc4Je8NkKJ4XZHQD9gEC6Pp2inxX-XxsdH4q-hcg_V4fZqLaPf0uCvW8fbleVM8bOM-TWSsqMpSLesMuay5zhEYg3TFU5FVNRMJrSstQKOWItV5QnOZpUrzTExniU4oX0S3R20_dJ8B_Vg6438bgxa74MtMyJxzyibw5gSGymFd9oNxMBzKv9b5DyhqgSw</recordid><startdate>200601</startdate><enddate>200601</enddate><creator>Futagami, Seiji</creator><creator>Hiratsuka, Tetsuro</creator><creator>Suzuki, Kenji</creator><creator>Kusunoki, Masanori</creator><creator>Wada, Ken</creator><creator>Miyake, Kazumasa</creator><creator>Ohashi, Kazushi</creator><creator>Shimizu, Masumi</creator><creator>Takahashi, Hidemi</creator><creator>Gudis, Katya</creator><creator>Kato, Shunji</creator><creator>Tsukui, Taku</creator><creator>Sakamoto, Choitsu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200601</creationdate><title>gammadelta T cells increase with gastric mucosal interleukin (IL)-7, IL-1beta, and Helicobacter pylori urease specific immunoglobulin levels via CCR2 upregulation in Helicobacter pylori gastritis</title><author>Futagami, Seiji ; Hiratsuka, Tetsuro ; Suzuki, Kenji ; Kusunoki, Masanori ; Wada, Ken ; Miyake, Kazumasa ; Ohashi, Kazushi ; Shimizu, Masumi ; Takahashi, Hidemi ; Gudis, Katya ; Kato, Shunji ; Tsukui, Taku ; Sakamoto, Choitsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p549-c0c65f9d6e39d3f8ea11a523576bd1740dbf7afef975f8408965cf367c654f403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Cells, Cultured</topic><topic>Chemotaxis, Leukocyte</topic><topic>Female</topic><topic>Gastric Mucosa - immunology</topic><topic>Gastric Mucosa - microbiology</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastritis - drug therapy</topic><topic>Gastritis - immunology</topic><topic>Gastritis - microbiology</topic><topic>Gastritis - pathology</topic><topic>Helicobacter Infections - drug therapy</topic><topic>Helicobacter Infections - immunology</topic><topic>Helicobacter Infections - microbiology</topic><topic>Helicobacter Infections - pathology</topic><topic>Helicobacter pylori - enzymology</topic><topic>Helicobacter pylori - immunology</topic><topic>Humans</topic><topic>Immunoglobulin A - biosynthesis</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Interleukin-1beta - biosynthesis</topic><topic>Interleukin-7 - biosynthesis</topic><topic>Leukocyte Common Antigens - analysis</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Receptors, Antigen, T-Cell, gamma-delta - analysis</topic><topic>Receptors, CCR2</topic><topic>Receptors, Chemokine - biosynthesis</topic><topic>T-Lymphocyte Subsets - immunology</topic><topic>T-Lymphocyte Subsets - microbiology</topic><topic>Urease - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Futagami, Seiji</creatorcontrib><creatorcontrib>Hiratsuka, Tetsuro</creatorcontrib><creatorcontrib>Suzuki, Kenji</creatorcontrib><creatorcontrib>Kusunoki, Masanori</creatorcontrib><creatorcontrib>Wada, Ken</creatorcontrib><creatorcontrib>Miyake, Kazumasa</creatorcontrib><creatorcontrib>Ohashi, Kazushi</creatorcontrib><creatorcontrib>Shimizu, Masumi</creatorcontrib><creatorcontrib>Takahashi, Hidemi</creatorcontrib><creatorcontrib>Gudis, Katya</creatorcontrib><creatorcontrib>Kato, Shunji</creatorcontrib><creatorcontrib>Tsukui, Taku</creatorcontrib><creatorcontrib>Sakamoto, Choitsu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Futagami, Seiji</au><au>Hiratsuka, Tetsuro</au><au>Suzuki, Kenji</au><au>Kusunoki, Masanori</au><au>Wada, Ken</au><au>Miyake, Kazumasa</au><au>Ohashi, Kazushi</au><au>Shimizu, Masumi</au><au>Takahashi, Hidemi</au><au>Gudis, Katya</au><au>Kato, Shunji</au><au>Tsukui, Taku</au><au>Sakamoto, Choitsu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>gammadelta T cells increase with gastric mucosal interleukin (IL)-7, IL-1beta, and Helicobacter pylori urease specific immunoglobulin levels via CCR2 upregulation in Helicobacter pylori gastritis</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2006-01</date><risdate>2006</risdate><volume>21</volume><issue>1 Pt 1</issue><spage>32</spage><epage>40</epage><pages>32-40</pages><issn>0815-9319</issn><abstract>The purpose of this study was to investigate possible factors that could impact on gammadelta T cell accumulation in the gastric mucosa.
Subjects were 22 Helicobacter pylori (H. pylori)-free and 75 H. pylori-infected mucosa biopsies classified into grades I approximately III gastritis as per our previous study. The number of gammadelta- and 45 RO-positive T cells were determined by immunostaining. Gastric mucosal anti-H. pylori urease specific antibodies and interleukin (IL)-1beta, IL-2, 4, 7, 10 and IL-12 levels were assayed by enzyme-linked immunosorbent assay (ELISA). CC chemokine receptor 2 (CCR2) expression levels, migration, and cytokine production in gammadelta T cells stimulated by H. pylori urease were also evaluated.
The gammadelta T cell count was significantly higher in grade III gastritis which exhibits strong immunoglobulin (Ig)A and IgG responses to H. pylori urease with lymphoid follicles than in other groups. gammadelta T cell count was significantly correlated with IL-1beta and interleukin-7 (IL-7) levels in the gastric mucosa. H. pylori urease immunoreactivity was detected in lamina propria of grade III gastritis, along with many gammadelta T cells. After H. pylori eradication therapy, the gammadelta T cell count in grade III gastritis significantly decreased. H. pylori urease stimulated significant increases in CCR2 expression levels, although to a lesser degree than those induced by IL-7 stimulation in both peripheral and mucosal gammadelta T cells. Interferon (IFN)-gamma and IL-10 production was also stimulated by H. pylori urease in peripheral gammadelta T cells.
Gastric mucosal increases in IL-7 and IL-1beta closely corresponded to the accumulation of gammadelta T cells in gastric mucosa. An association was also seen between gammadelta T cell accumulation and H. pylori urease-specific Ig levels.</abstract><cop>Australia</cop><pmid>16706809</pmid><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0815-9319 |
| ispartof | Journal of gastroenterology and hepatology, 2006-01, Vol.21 (1 Pt 1), p.32-40 |
| issn | 0815-9319 |
| language | eng |
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| subjects | Adult Aged Aged, 80 and over Anti-Bacterial Agents - therapeutic use Anti-Ulcer Agents - therapeutic use Cells, Cultured Chemotaxis, Leukocyte Female Gastric Mucosa - immunology Gastric Mucosa - microbiology Gastric Mucosa - pathology Gastritis - drug therapy Gastritis - immunology Gastritis - microbiology Gastritis - pathology Helicobacter Infections - drug therapy Helicobacter Infections - immunology Helicobacter Infections - microbiology Helicobacter Infections - pathology Helicobacter pylori - enzymology Helicobacter pylori - immunology Humans Immunoglobulin A - biosynthesis Immunoglobulin G - biosynthesis Interleukin-1beta - biosynthesis Interleukin-7 - biosynthesis Leukocyte Common Antigens - analysis Male Middle Aged Receptors, Antigen, T-Cell, gamma-delta - analysis Receptors, CCR2 Receptors, Chemokine - biosynthesis T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - microbiology Urease - immunology |
| title | gammadelta T cells increase with gastric mucosal interleukin (IL)-7, IL-1beta, and Helicobacter pylori urease specific immunoglobulin levels via CCR2 upregulation in Helicobacter pylori gastritis |
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