The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B
We studied the hepatitis B virus (HBV)‐DNA levels below which the development of cirrhosis‐related complications became unlikely in chronic hepatitis B (CHB). Seventy‐nine Chinese CHB patients with cirrhosis‐related complications and 158 age‐, sex‐ and HBeAg status‐matched patients without complicat...
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| Veröffentlicht in: | Journal of viral hepatitis 2005-07, Vol.12 (4), p.373-379 |
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| container_title | Journal of viral hepatitis |
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| creator | Yuan, H.-J. Yuen, M.-F. Ka-Ho Wong, D. Sablon, E. Lai, C.-L. |
| description | We studied the hepatitis B virus (HBV)‐DNA levels below which the development of cirrhosis‐related complications became unlikely in chronic hepatitis B (CHB). Seventy‐nine Chinese CHB patients with cirrhosis‐related complications and 158 age‐, sex‐ and HBeAg status‐matched patients without complications were enrolled. The precore and core promoter mutations were detected by the Line Probe assay (LiPA). HBVDNA levels were determined by Digene assay and Cobas Amplicor Monitor test. Patients with complications had higher HBVDNA levels than those without complications (P = 0.02). HBeAg‐positive patients with complications had similar alanine transferase (ALT) and HBVDNA levels and frequency of precore mutations, but higher frequency of core promoter mutations (P = 0.003), compared with those without complications. Anti‐HBe‐positive patients with complications had higher ALT and HBVDNA levels (P |
| doi_str_mv | 10.1111/j.1365-2893.2005.00603.x |
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Seventy‐nine Chinese CHB patients with cirrhosis‐related complications and 158 age‐, sex‐ and HBeAg status‐matched patients without complications were enrolled. The precore and core promoter mutations were detected by the Line Probe assay (LiPA). HBVDNA levels were determined by Digene assay and Cobas Amplicor Monitor test. Patients with complications had higher HBVDNA levels than those without complications (P = 0.02). HBeAg‐positive patients with complications had similar alanine transferase (ALT) and HBVDNA levels and frequency of precore mutations, but higher frequency of core promoter mutations (P = 0.003), compared with those without complications. Anti‐HBe‐positive patients with complications had higher ALT and HBVDNA levels (P < 0.01) but similar frequency of precore and core promoter mutations, compared with those without complications. Anti‐HBe patients (24.5%) with complications had HBVDNA levels <104 copies/mL. The major factor for the development of cirrhotic complications was viral loads but cirrhotic complications continued to develop in patients with HBVDNA levels below 104 copies/mL.</description><identifier>ISSN: 1352-0504</identifier><identifier>EISSN: 1365-2893</identifier><identifier>DOI: 10.1111/j.1365-2893.2005.00603.x</identifier><identifier>PMID: 15985007</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>Adult ; Aged ; Alanine Transaminase - blood ; Asian Continental Ancestry Group ; China ; complications ; core promoter mutations ; DNA, Viral - blood ; Female ; HBV-DNA ; Hepatitis B virus ; Hepatitis B virus - genetics ; Hepatitis B, Chronic - blood ; Hepatitis B, Chronic - complications ; Humans ; Liver Cirrhosis - blood ; Liver Cirrhosis - complications ; Liver Cirrhosis - virology ; Male ; Middle Aged ; Mutation ; precore mutations ; Promoter Regions, Genetic ; Viral Load</subject><ispartof>Journal of viral hepatitis, 2005-07, Vol.12 (4), p.373-379</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4353-5094a68e8451b25deb69e2894d016df225fc8ee86c3750931ea7c877e214733c3</citedby><cites>FETCH-LOGICAL-c4353-5094a68e8451b25deb69e2894d016df225fc8ee86c3750931ea7c877e214733c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2893.2005.00603.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2893.2005.00603.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15985007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, H.-J.</creatorcontrib><creatorcontrib>Yuen, M.-F.</creatorcontrib><creatorcontrib>Ka-Ho Wong, D.</creatorcontrib><creatorcontrib>Sablon, E.</creatorcontrib><creatorcontrib>Lai, C.-L.</creatorcontrib><title>The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B</title><title>Journal of viral hepatitis</title><addtitle>J Viral Hepat</addtitle><description>We studied the hepatitis B virus (HBV)‐DNA levels below which the development of cirrhosis‐related complications became unlikely in chronic hepatitis B (CHB). Seventy‐nine Chinese CHB patients with cirrhosis‐related complications and 158 age‐, sex‐ and HBeAg status‐matched patients without complications were enrolled. The precore and core promoter mutations were detected by the Line Probe assay (LiPA). HBVDNA levels were determined by Digene assay and Cobas Amplicor Monitor test. Patients with complications had higher HBVDNA levels than those without complications (P = 0.02). HBeAg‐positive patients with complications had similar alanine transferase (ALT) and HBVDNA levels and frequency of precore mutations, but higher frequency of core promoter mutations (P = 0.003), compared with those without complications. Anti‐HBe‐positive patients with complications had higher ALT and HBVDNA levels (P < 0.01) but similar frequency of precore and core promoter mutations, compared with those without complications. Anti‐HBe patients (24.5%) with complications had HBVDNA levels <104 copies/mL. The major factor for the development of cirrhotic complications was viral loads but cirrhotic complications continued to develop in patients with HBVDNA levels below 104 copies/mL.</description><subject>Adult</subject><subject>Aged</subject><subject>Alanine Transaminase - blood</subject><subject>Asian Continental Ancestry Group</subject><subject>China</subject><subject>complications</subject><subject>core promoter mutations</subject><subject>DNA, Viral - blood</subject><subject>Female</subject><subject>HBV-DNA</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B, Chronic - blood</subject><subject>Hepatitis B, Chronic - complications</subject><subject>Humans</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - virology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>precore mutations</subject><subject>Promoter Regions, Genetic</subject><subject>Viral Load</subject><issn>1352-0504</issn><issn>1365-2893</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV1P2zAUhi20aTDYX0C-2l0yf8QfkbiBwugAsUlAubRS51RxSZNgp2v593NIxS7BN7bs5znWOS9CmJKUxvVjmVIuRcJ0zlNGiEgJkYSn2z108PbwaTgLlhBBsn30NYQlIZQzQb-gfSpyLQhRB6i9rwB7qIvetU2oXIfn0G8AGjw9myXnt6e4hr9QB1w0JbbO-6oNLiSvBsSbdtXVzo42dg2eVK6BAHjj-grbyreNs7iCLhK9C_jsCH1eFHWAb7v9ED38vLifTJOb35e_Jqc3ic244IkgeVZIDToTdM5ECXOZQ-wqKwmV5YIxsbAaQEvLVWQ5hUJZrRQwminOLT9E38e6nW-f1xB6s3LBQl0XDbTrYKTKNZNKvwtSJSSVYgD1CFrfhuBhYTrvVoV_MZSYIRWzNMPwzTB8M6RiXlMx26ge7_5Yz1dQ_hd3MUTgZAQ2roaXDxc2V7NpPEQ9GXUXeti-6YV_in3GAZnH20uj_9w93qnZtdH8H3pCqgo</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Yuan, H.-J.</creator><creator>Yuen, M.-F.</creator><creator>Ka-Ho Wong, D.</creator><creator>Sablon, E.</creator><creator>Lai, C.-L.</creator><general>Blackwell Science Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200507</creationdate><title>The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B</title><author>Yuan, H.-J. ; Yuen, M.-F. ; Ka-Ho Wong, D. ; Sablon, E. ; Lai, C.-L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4353-5094a68e8451b25deb69e2894d016df225fc8ee86c3750931ea7c877e214733c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alanine Transaminase - blood</topic><topic>Asian Continental Ancestry Group</topic><topic>China</topic><topic>complications</topic><topic>core promoter mutations</topic><topic>DNA, Viral - blood</topic><topic>Female</topic><topic>HBV-DNA</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B, Chronic - blood</topic><topic>Hepatitis B, Chronic - complications</topic><topic>Humans</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - virology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>precore mutations</topic><topic>Promoter Regions, Genetic</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, H.-J.</creatorcontrib><creatorcontrib>Yuen, M.-F.</creatorcontrib><creatorcontrib>Ka-Ho Wong, D.</creatorcontrib><creatorcontrib>Sablon, E.</creatorcontrib><creatorcontrib>Lai, C.-L.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of viral hepatitis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, H.-J.</au><au>Yuen, M.-F.</au><au>Ka-Ho Wong, D.</au><au>Sablon, E.</au><au>Lai, C.-L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B</atitle><jtitle>Journal of viral hepatitis</jtitle><addtitle>J Viral Hepat</addtitle><date>2005-07</date><risdate>2005</risdate><volume>12</volume><issue>4</issue><spage>373</spage><epage>379</epage><pages>373-379</pages><issn>1352-0504</issn><eissn>1365-2893</eissn><abstract>We studied the hepatitis B virus (HBV)‐DNA levels below which the development of cirrhosis‐related complications became unlikely in chronic hepatitis B (CHB). Seventy‐nine Chinese CHB patients with cirrhosis‐related complications and 158 age‐, sex‐ and HBeAg status‐matched patients without complications were enrolled. The precore and core promoter mutations were detected by the Line Probe assay (LiPA). HBVDNA levels were determined by Digene assay and Cobas Amplicor Monitor test. Patients with complications had higher HBVDNA levels than those without complications (P = 0.02). HBeAg‐positive patients with complications had similar alanine transferase (ALT) and HBVDNA levels and frequency of precore mutations, but higher frequency of core promoter mutations (P = 0.003), compared with those without complications. Anti‐HBe‐positive patients with complications had higher ALT and HBVDNA levels (P < 0.01) but similar frequency of precore and core promoter mutations, compared with those without complications. Anti‐HBe patients (24.5%) with complications had HBVDNA levels <104 copies/mL. The major factor for the development of cirrhotic complications was viral loads but cirrhotic complications continued to develop in patients with HBVDNA levels below 104 copies/mL.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>15985007</pmid><doi>10.1111/j.1365-2893.2005.00603.x</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Alanine Transaminase - blood Asian Continental Ancestry Group China complications core promoter mutations DNA, Viral - blood Female HBV-DNA Hepatitis B virus Hepatitis B virus - genetics Hepatitis B, Chronic - blood Hepatitis B, Chronic - complications Humans Liver Cirrhosis - blood Liver Cirrhosis - complications Liver Cirrhosis - virology Male Middle Aged Mutation precore mutations Promoter Regions, Genetic Viral Load |
| title | The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B |
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