Bcl-w promotes gastric cancer cell invasion by inducing matrix metalloproteinase-2 expression via phosphoinositide 3-kinase, Akt, and Sp1

Given a previous report that Bcl-w is expressed in gastric cancer cells, particularly in those of an infiltrative morphology, we investigated whether Bcl-w expression influences the invasiveness of gastric cancer cells. To accomplish this, Bcl-w was overexpressed in adherent types of gastric adenoca...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2006-05, Vol.66 (10), p.4991-4995
Hauptverfasser:	IN HWA BAE, PARK, Myung-Jin, SUNG HWAN YOON, SUNG WOOK KANG, LEE, Seung-Sook, CHOI, Kyung-Mi, UM, Hong-Duck
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - enzymology Adenocarcinoma - pathology Antineoplastic agents Apoptosis Regulatory Proteins - biosynthesis Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Cell Line, Tumor Enzyme Induction Gastroenterology. Liver. Pancreas. Abdomen Humans Matrix Metalloproteinase 2 - biosynthesis Medical sciences Neoplasm Invasiveness Pharmacology. Drug treatments Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Sp1 Transcription Factor - metabolism Stomach Neoplasms - enzymology Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Transfection Tumors
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