p63-Specific Activation of the BPAG-1e Promoter
p63, a member of the p53 superfamily, is an essential cell fate determinant for stratified epithelium. Deficiency of p63 leads to lack of differentiated epithelium from the skin and the presence of trace undifferentiated cells left in the dermis. We found that transcriptionally active isoforms of p6...
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| Veröffentlicht in: | Journal of investigative dermatology 2005-07, Vol.125 (1), p.52-60 |
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| container_title | Journal of investigative dermatology |
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| creator | Osada, Motonobu Nagakawa, Yuichi Park, Hannah Lui Yamashita, Keishi Wu, Guojun Sook Kim, Myoung Fomenkov, Alexey Trink, Barry Sidransky, David |
| description | p63, a member of the p53 superfamily, is an essential cell fate determinant for stratified epithelium. Deficiency of p63 leads to lack of differentiated epithelium from the skin and the presence of trace undifferentiated cells left in the dermis. We found that transcriptionally active isoforms of p63, TAp63β and TAp63γ, activated the skin-specific promoter of bullous pemphigoid antigen 1 (BPAG-1). The p63-response element was localized between bases -177 and -153 upstream of exon 1 in the BPAG-1e promoter, whereas regions surrounding the response element suppressed transcriptional responses to p53 and TAp73β, resulting in p63-specific activation of the promoter. This represents a novel molecular mechanism by which target gene induction by p63 is distinguished from induction by other p53 family members. |
| doi_str_mv | 10.1111/j.0022-202X.2005.23801.x |
| format | Article |
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Deficiency of p63 leads to lack of differentiated epithelium from the skin and the presence of trace undifferentiated cells left in the dermis. We found that transcriptionally active isoforms of p63, TAp63β and TAp63γ, activated the skin-specific promoter of bullous pemphigoid antigen 1 (BPAG-1). The p63-response element was localized between bases -177 and -153 upstream of exon 1 in the BPAG-1e promoter, whereas regions surrounding the response element suppressed transcriptional responses to p53 and TAp73β, resulting in p63-specific activation of the promoter. This represents a novel molecular mechanism by which target gene induction by p63 is distinguished from induction by other p53 family members.</description><identifier>ISSN: 0022-202X</identifier><identifier>EISSN: 1523-1747</identifier><identifier>DOI: 10.1111/j.0022-202X.2005.23801.x</identifier><identifier>PMID: 15982302</identifier><identifier>CODEN: JIDEAE</identifier><language>eng</language><publisher>Danvers, MA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; BPAG-1 ; Carrier Proteins - metabolism ; Cytoskeletal Proteins - metabolism ; Dermatology ; DNA-Binding Proteins ; Dystonin ; Epithelium - metabolism ; Gene Expression Regulation ; Genes, Tumor Suppressor ; Immunohistochemistry ; Medical sciences ; Mice ; Nerve Tissue Proteins - metabolism ; p53 ; p53-response element ; p63 ; Phosphoproteins - metabolism ; Promoter Regions, Genetic ; Trans-Activators - metabolism ; Transcription Factors ; Transcriptional Activation ; Tumor Suppressor Proteins</subject><ispartof>Journal of investigative dermatology, 2005-07, Vol.125 (1), p.52-60</ispartof><rights>2005 The Society for Investigative Dermatology, Inc</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Nature Publishing Group Jul 2005</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c576t-f7da8244ac34ca6a0711a6887a3165d59b8797aea956e31bee6f7263a0ff76e83</citedby><cites>FETCH-LOGICAL-c576t-f7da8244ac34ca6a0711a6887a3165d59b8797aea956e31bee6f7263a0ff76e83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/210380204?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,778,782,27907,27908,64366,64368,64370,72220</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16955408$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15982302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Osada, Motonobu</creatorcontrib><creatorcontrib>Nagakawa, Yuichi</creatorcontrib><creatorcontrib>Park, Hannah Lui</creatorcontrib><creatorcontrib>Yamashita, Keishi</creatorcontrib><creatorcontrib>Wu, Guojun</creatorcontrib><creatorcontrib>Sook Kim, Myoung</creatorcontrib><creatorcontrib>Fomenkov, Alexey</creatorcontrib><creatorcontrib>Trink, Barry</creatorcontrib><creatorcontrib>Sidransky, David</creatorcontrib><title>p63-Specific Activation of the BPAG-1e Promoter</title><title>Journal of investigative dermatology</title><addtitle>J Invest Dermatol</addtitle><description>p63, a member of the p53 superfamily, is an essential cell fate determinant for stratified epithelium. Deficiency of p63 leads to lack of differentiated epithelium from the skin and the presence of trace undifferentiated cells left in the dermis. We found that transcriptionally active isoforms of p63, TAp63β and TAp63γ, activated the skin-specific promoter of bullous pemphigoid antigen 1 (BPAG-1). The p63-response element was localized between bases -177 and -153 upstream of exon 1 in the BPAG-1e promoter, whereas regions surrounding the response element suppressed transcriptional responses to p53 and TAp73β, resulting in p63-specific activation of the promoter. This represents a novel molecular mechanism by which target gene induction by p63 is distinguished from induction by other p53 family members.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BPAG-1</subject><subject>Carrier Proteins - metabolism</subject><subject>Cytoskeletal Proteins - metabolism</subject><subject>Dermatology</subject><subject>DNA-Binding Proteins</subject><subject>Dystonin</subject><subject>Epithelium - metabolism</subject><subject>Gene Expression Regulation</subject><subject>Genes, Tumor Suppressor</subject><subject>Immunohistochemistry</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>p53</subject><subject>p53-response element</subject><subject>p63</subject><subject>Phosphoproteins - metabolism</subject><subject>Promoter Regions, Genetic</subject><subject>Trans-Activators - metabolism</subject><subject>Transcription Factors</subject><subject>Transcriptional Activation</subject><subject>Tumor Suppressor Proteins</subject><issn>0022-202X</issn><issn>1523-1747</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqFkE1LHEEQhpsQiRvNX5BBiLcZq797jqsYExAUEiG3prenGnvZnV67Z0X_vTPuEiEXi4K6PFXU-xBSUWjoWOfLBoCxmgH72zAA2TBugDbPn8iMSsZrqoX-TGb_oEPytZQlAFVCmi_kkMrWMA5sRs43ite_N-hjiL6a-yE-uSGmvkqhGh6wuribX9cUq7uc1mnAfEwOglsV_LafR-T-x9Wfy5_1ze31r8v5Te2lVkMddOcME8J5LrxTDjSlThmjHadKdrJdGN1qh66VCjldIKqgmeIOQtAKDT8iZ7u7m5wet1gGu47F42rlekzbYpVuDRUSPgRpK8YGMYKn_4HLtM39GMIyCqM_9gaZHeRzKiVjsJsc1y6_WAp2Um-XdrJqJ6t2Um_f1NvncfVkf3-7WGP3vrh3PQLf94Ar3q1Cdr2P5Z1TrZQCpugXOw5Hv08Rsy0-Yu-xixn9YLsUP_7mFVYxnmM</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Osada, Motonobu</creator><creator>Nagakawa, Yuichi</creator><creator>Park, Hannah Lui</creator><creator>Yamashita, Keishi</creator><creator>Wu, Guojun</creator><creator>Sook Kim, Myoung</creator><creator>Fomenkov, Alexey</creator><creator>Trink, Barry</creator><creator>Sidransky, David</creator><general>Elsevier Inc</general><general>Nature Publishing</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>p63-Specific Activation of the BPAG-1e Promoter</title><author>Osada, Motonobu ; 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Deficiency of p63 leads to lack of differentiated epithelium from the skin and the presence of trace undifferentiated cells left in the dermis. We found that transcriptionally active isoforms of p63, TAp63β and TAp63γ, activated the skin-specific promoter of bullous pemphigoid antigen 1 (BPAG-1). The p63-response element was localized between bases -177 and -153 upstream of exon 1 in the BPAG-1e promoter, whereas regions surrounding the response element suppressed transcriptional responses to p53 and TAp73β, resulting in p63-specific activation of the promoter. This represents a novel molecular mechanism by which target gene induction by p63 is distinguished from induction by other p53 family members.</abstract><cop>Danvers, MA</cop><pub>Elsevier Inc</pub><pmid>15982302</pmid><doi>10.1111/j.0022-202X.2005.23801.x</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of investigative dermatology, 2005-07, Vol.125 (1), p.52-60 |
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| subjects | Animals Biological and medical sciences BPAG-1 Carrier Proteins - metabolism Cytoskeletal Proteins - metabolism Dermatology DNA-Binding Proteins Dystonin Epithelium - metabolism Gene Expression Regulation Genes, Tumor Suppressor Immunohistochemistry Medical sciences Mice Nerve Tissue Proteins - metabolism p53 p53-response element p63 Phosphoproteins - metabolism Promoter Regions, Genetic Trans-Activators - metabolism Transcription Factors Transcriptional Activation Tumor Suppressor Proteins |
| title | p63-Specific Activation of the BPAG-1e Promoter |
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