Immunoglobulin class-switch recombination occurs in mantle cell lymphomas

Mantle cell lymphoma (MCL) is an IgM‐expressing B cell lymphoma that originates from naive B cells and responds poorly to chemotherapy. We show here that several MCLs harbour isotype‐switched subclones. Similar to the situation in normal B cells, in vitro stimulation of MCL cell lines with CD40 liga...

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Veröffentlicht in:	The Journal of pathology 2006-06, Vol.209 (2), p.250-257
Hauptverfasser:	Klapper, W, Szczepanowski, M, Heidorn, K, Müschen, M, Liedtke, S, Sotnikova, A, Andersen, NS, Greeve, J, Parwaresch, R
Format:	Artikel
Sprache:	eng
Schlagworte:	activation-induced cytidine deaminase Biological and medical sciences CD40 Antigens - immunology Cell Line, Tumor class-switch Cytidine Deaminase - immunology Dendritic Cells, Follicular - immunology Genes, Immunoglobulin Heavy Chain - genetics Genes, Immunoglobulin Heavy Chain - immunology Hematologic and hematopoietic diseases Humans immunoglobulin Immunoglobulin Class Switching - genetics Immunoglobulin Class Switching - immunology Immunoglobulin G - genetics Immunoglobulin G - immunology Immunohistochemistry - methods Interleukin-4 - immunology Investigative techniques, diagnostic techniques (general aspects) Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Mantle-Cell - genetics Lymphoma, Mantle-Cell - immunology mantle cell lymphoma Medical sciences Mutation - genetics Mutation - immunology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Recombination, Genetic - genetics Recombination, Genetic - immunology Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Messenger - analysis RNA, Neoplasm - analysis Transcription, Genetic - genetics Transcription, Genetic - immunology
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