Weight adjustment of serum markers in early first-trimester prenatal screening for Down syndrome
Objective To assess whether existing weight correction formulas for PAPP‐A and free‐beta‐hCG developed for weeks 11 to 14 can be applied to pregnancies in weeks 8 to 10. Methods Development of formulas based on limited data sets of 8‐ to 10‐week pregnancies and comparison with existing formulas. Cal...
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| Veröffentlicht in: | Prenatal diagnosis 2005-06, Vol.25 (6), p.484-488 |
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| container_title | Prenatal diagnosis |
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| creator | Sørensen, Tina Larsen, Severin Olesen Christiansen, Michael |
| description | Objective
To assess whether existing weight correction formulas for PAPP‐A and free‐beta‐hCG developed for weeks 11 to 14 can be applied to pregnancies in weeks 8 to 10.
Methods
Development of formulas based on limited data sets of 8‐ to 10‐week pregnancies and comparison with existing formulas. Calculation of median MoMs adjusted with different formulas for weight correction.
Results
Weight correction formulas for the gestational age of 11 to 14 weeks were not appropriate in the 8‐ to 10‐week gestational age interval for PAPP‐A, whereas existing weight correction formulas could be applied to free‐beta‐hCG, independent of gestational age interval.
Conclusion
If PAPP‐A is used in different gestational age intervals, weight corrections should be developed for the interval. Copyright © 2005 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/pd.1176 |
| format | Article |
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To assess whether existing weight correction formulas for PAPP‐A and free‐beta‐hCG developed for weeks 11 to 14 can be applied to pregnancies in weeks 8 to 10.
Methods
Development of formulas based on limited data sets of 8‐ to 10‐week pregnancies and comparison with existing formulas. Calculation of median MoMs adjusted with different formulas for weight correction.
Results
Weight correction formulas for the gestational age of 11 to 14 weeks were not appropriate in the 8‐ to 10‐week gestational age interval for PAPP‐A, whereas existing weight correction formulas could be applied to free‐beta‐hCG, independent of gestational age interval.
Conclusion
If PAPP‐A is used in different gestational age intervals, weight corrections should be developed for the interval. Copyright © 2005 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.1176</identifier><identifier>PMID: 15966040</identifier><identifier>CODEN: PRDIDM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Biological and medical sciences ; Birth control ; Body Weight ; Chorionic Gonadotropin, beta Subunit, Human - blood ; Down ; Down Syndrome - diagnosis ; Female ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Hormonal contraception ; Humans ; Linear Models ; maternal ; Medical sciences ; Pregnancy ; Pregnancy Trimester, First ; Pregnancy-Associated Plasma Protein-A - analysis ; prenatal ; Prenatal Diagnosis - methods ; screening ; weight</subject><ispartof>Prenatal diagnosis, 2005-06, Vol.25 (6), p.484-488</ispartof><rights>Copyright © 2005 John Wiley & Sons, Ltd.</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4146-e8fb01357417943906afd12f0af5deeeb4e97664b4aa8d97af8de7286566618c3</citedby><cites>FETCH-LOGICAL-c4146-e8fb01357417943906afd12f0af5deeeb4e97664b4aa8d97af8de7286566618c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.1176$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.1176$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16911975$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15966040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sørensen, Tina</creatorcontrib><creatorcontrib>Larsen, Severin Olesen</creatorcontrib><creatorcontrib>Christiansen, Michael</creatorcontrib><title>Weight adjustment of serum markers in early first-trimester prenatal screening for Down syndrome</title><title>Prenatal diagnosis</title><addtitle>Prenat. Diagn</addtitle><description>Objective
To assess whether existing weight correction formulas for PAPP‐A and free‐beta‐hCG developed for weeks 11 to 14 can be applied to pregnancies in weeks 8 to 10.
Methods
Development of formulas based on limited data sets of 8‐ to 10‐week pregnancies and comparison with existing formulas. Calculation of median MoMs adjusted with different formulas for weight correction.
Results
Weight correction formulas for the gestational age of 11 to 14 weeks were not appropriate in the 8‐ to 10‐week gestational age interval for PAPP‐A, whereas existing weight correction formulas could be applied to free‐beta‐hCG, independent of gestational age interval.
Conclusion
If PAPP‐A is used in different gestational age intervals, weight corrections should be developed for the interval. Copyright © 2005 John Wiley & Sons, Ltd.</description><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Body Weight</subject><subject>Chorionic Gonadotropin, beta Subunit, Human - blood</subject><subject>Down</subject><subject>Down Syndrome - diagnosis</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hormonal contraception</subject><subject>Humans</subject><subject>Linear Models</subject><subject>maternal</subject><subject>Medical sciences</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First</subject><subject>Pregnancy-Associated Plasma Protein-A - analysis</subject><subject>prenatal</subject><subject>Prenatal Diagnosis - methods</subject><subject>screening</subject><subject>weight</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0cFu1DAQBmALgehSEG-AfAEOKMWTOHZ8rFq6rVQVhArtzXjjcXFJnGAnKvv2uNqInipOnsOnGc_8hLwGdgCMlR9HewAgxROyAqZkwcqyekpWDHJdNTXskRcp3WbYlEo-J3tQKyEYZyvy4wr9zc-JGns7p6nHMNHB0YRx7mlv4i-MifpA0cRuS52PaSqm6HtME0Y6RgxmMh1NbUQMPtxQN0R6PNwFmrbBxqHHl-SZM13CV8u7T76dfLo8Oi3OP6_Pjg7Pi5YDFwU2bsOgqiUHqXilmDDOQumYcbVFxA1HJYXgG25MY5U0rrEoy0bUQgho2mqfvNv1HePwe87_071PLXadCTjMSQuppKqg-S8EyZVqQGT4fgfbOKQU0ekxb27iVgPT91fXo9X3V8_yzdJy3vRoH9xy5gzeLsCk1nQumtD69OCEghxVnd2HnbvzHW4fm6e_HC9ji532OY0__3ROLW9byVpfXaz118v6en1dnujv1V9igqdW</recordid><startdate>200506</startdate><enddate>200506</enddate><creator>Sørensen, Tina</creator><creator>Larsen, Severin Olesen</creator><creator>Christiansen, Michael</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>200506</creationdate><title>Weight adjustment of serum markers in early first-trimester prenatal screening for Down syndrome</title><author>Sørensen, Tina ; Larsen, Severin Olesen ; Christiansen, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4146-e8fb01357417943906afd12f0af5deeeb4e97664b4aa8d97af8de7286566618c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Body Weight</topic><topic>Chorionic Gonadotropin, beta Subunit, Human - blood</topic><topic>Down</topic><topic>Down Syndrome - diagnosis</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hormonal contraception</topic><topic>Humans</topic><topic>Linear Models</topic><topic>maternal</topic><topic>Medical sciences</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First</topic><topic>Pregnancy-Associated Plasma Protein-A - analysis</topic><topic>prenatal</topic><topic>Prenatal Diagnosis - methods</topic><topic>screening</topic><topic>weight</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sørensen, Tina</creatorcontrib><creatorcontrib>Larsen, Severin Olesen</creatorcontrib><creatorcontrib>Christiansen, Michael</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sørensen, Tina</au><au>Larsen, Severin Olesen</au><au>Christiansen, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Weight adjustment of serum markers in early first-trimester prenatal screening for Down syndrome</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat. Diagn</addtitle><date>2005-06</date><risdate>2005</risdate><volume>25</volume><issue>6</issue><spage>484</spage><epage>488</epage><pages>484-488</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><coden>PRDIDM</coden><abstract>Objective
To assess whether existing weight correction formulas for PAPP‐A and free‐beta‐hCG developed for weeks 11 to 14 can be applied to pregnancies in weeks 8 to 10.
Methods
Development of formulas based on limited data sets of 8‐ to 10‐week pregnancies and comparison with existing formulas. Calculation of median MoMs adjusted with different formulas for weight correction.
Results
Weight correction formulas for the gestational age of 11 to 14 weeks were not appropriate in the 8‐ to 10‐week gestational age interval for PAPP‐A, whereas existing weight correction formulas could be applied to free‐beta‐hCG, independent of gestational age interval.
Conclusion
If PAPP‐A is used in different gestational age intervals, weight corrections should be developed for the interval. Copyright © 2005 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>15966040</pmid><doi>10.1002/pd.1176</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-3851 |
| ispartof | Prenatal diagnosis, 2005-06, Vol.25 (6), p.484-488 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Biological and medical sciences Birth control Body Weight Chorionic Gonadotropin, beta Subunit, Human - blood Down Down Syndrome - diagnosis Female Gestational Age Gynecology. Andrology. Obstetrics Hormonal contraception Humans Linear Models maternal Medical sciences Pregnancy Pregnancy Trimester, First Pregnancy-Associated Plasma Protein-A - analysis prenatal Prenatal Diagnosis - methods screening weight |
| title | Weight adjustment of serum markers in early first-trimester prenatal screening for Down syndrome |
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