Crystal Structures of Potent Thiol-Based Inhibitors Bound to Carboxypeptidase B

This paper presents the crystal structure of porcine pancreatic carboxypeptidase B (pp-CpB) in complex with a variety of thiol-based inhibitors that were developed as antagonists of activated thrombin-activatable fibrinolysis inhibitor (TAFIa). Recent studies have indicated that a selective inhibito...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Biochemistry (Easton) 2005-07, Vol.44 (26), p.9339-9347
Hauptverfasser:	Adler, Marc, Bryant, Judi, Buckman, Brad, Islam, Imadul, Larsen, Brent, Finster, Silke, Kent, Lorraine, May, Karen, Mohan, Raju, Yuan, Shendong, Whitlow, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carboxypeptidase B - antagonists & inhibitors Carboxypeptidase B - metabolism Crystallography, X-Ray Hydrogen Bonding Models, Molecular Pancreas - enzymology Protease Inhibitors - chemistry Protease Inhibitors - metabolism Protease Inhibitors - pharmacology Protein Conformation Sulfhydryl Compounds - chemistry Sulfhydryl Compounds - metabolism Sulfhydryl Compounds - pharmacology Swine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!