Reduction of postincisional allodynia by subcutaneous bupivacaine: findings with a new model in the hairy skin of the rat

An incision of hairy skin of the rat's back provides a new model for postincisional pain to determine the importance of cutaneous anesthesia. Male Sprague-Dawley rats were anesthetized with sevoflurane and given a 0.6-ml subcutaneous injection of bupivacaine (0.25%) under the incision site or t...

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Veröffentlicht in:	Anesthesiology (Philadelphia) 2005-07, Vol.103 (1), p.113-125
Hauptverfasser:	Duarte, Adriana M, Pospisilova, Eva, Reilly, Erin, Mujenda, Florence, Hamaya, Yoshihiro, Strichartz, Gary R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bupivacaine - administration & dosage Hair Follicle - innervation Hyperalgesia - drug therapy Hyperalgesia - physiopathology Injections, Subcutaneous Male Pain Measurement - drug effects Pain Measurement - methods Pain, Postoperative - drug therapy Pain, Postoperative - physiopathology Rats Rats, Sprague-Dawley Skin - drug effects Skin - innervation Time Factors
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