Tumor Necrosis Factor Inhibition and Invasive Fungal Infections
Candida albicans and Aspergillus fumigatus occur ubiquitously in nature; C. albicans is part of the natural flora of most healthy individuals, and A. fumigatus is commonly found in soil, plant debris, and indoor air. Neither fungus poses a threat to healthy individuals, but each can cause fatal infe...
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| Veröffentlicht in: | Clinical infectious diseases 2005-08, Vol.41 (Supplement-3), p.S208-S212 |
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| container_end_page | S212 |
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| container_issue | Supplement-3 |
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| container_title | Clinical infectious diseases |
| container_volume | 41 |
| creator | Filler, Scott G. Yeaman, Michael R. Sheppard, Donald C. |
| description | Candida albicans and Aspergillus fumigatus occur ubiquitously in nature; C. albicans is part of the natural flora of most healthy individuals, and A. fumigatus is commonly found in soil, plant debris, and indoor air. Neither fungus poses a threat to healthy individuals, but each can cause fatal infections in immunocompromised patients. The use of tumor necrosis factor (TNF) antagonists for the treatment of rheumatoid arthritis and other autoimmune diseases has been associated with an increased incidence of opportunistic infections, including infections with both of these fungi. Because the use of TNF antagonists is expected to increase in the future, understanding the role that TNF plays and the effect of its antagonism on host defense against infections with these fungi is critical for reducing the associated morbidity and mortality. |
| doi_str_mv | 10.1086/430000 |
| format | Article |
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Neither fungus poses a threat to healthy individuals, but each can cause fatal infections in immunocompromised patients. The use of tumor necrosis factor (TNF) antagonists for the treatment of rheumatoid arthritis and other autoimmune diseases has been associated with an increased incidence of opportunistic infections, including infections with both of these fungi. 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Neither fungus poses a threat to healthy individuals, but each can cause fatal infections in immunocompromised patients. The use of tumor necrosis factor (TNF) antagonists for the treatment of rheumatoid arthritis and other autoimmune diseases has been associated with an increased incidence of opportunistic infections, including infections with both of these fungi. Because the use of TNF antagonists is expected to increase in the future, understanding the role that TNF plays and the effect of its antagonism on host defense against infections with these fungi is critical for reducing the associated morbidity and mortality.</description><subject>Aspergillosis</subject><subject>Autoimmune diseases</subject><subject>Candida albicans</subject><subject>Drug therapy</subject><subject>Endothelial cells</subject><subject>Fungal infections</subject><subject>Fungi</subject><subject>Gangrene</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Infections</subject><subject>Inhibitor drugs</subject><subject>Leukocytes</subject><subject>Medical treatment</subject><subject>Mice</subject><subject>Mycoses - immunology</subject><subject>Neutrophils</subject><subject>Opportunistic Infections - immunology</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor Necrosis Factor-alpha - physiology</subject><subject>Tumor necrosis factors</subject><subject>Tumors</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkF9LwzAUxYMoTqd-ApHhg2_V3CZNmieR4dxwKMKE4UtI80c7t3Y27dBvb2bHBF-8L_cezo8D9yB0AvgScMquKMFhdtABJIRHLBGwG26cpBFNSdpBh97PMAZIcbKPOpCIlAgcH6DrSbMoq96D1VXpc98bKF0HPSre8iyv87LoqcIEuVI-X9neoCle1TxoZ_Xa9Udoz6m5t8eb3UXPg9tJfxiNH-9G_ZtxpKmI64iBASy4ddoyTrNYOZxZ5kzG45iZOFUEHDWaAdVKG2GMownjxhoFTmDgpIsu2txlVX401tdykXtt53NV2LLxknHBGcf4XxA4SwhlNIDnf8BZ2VRFeELGIEQI-4E2aet6fGWdXFb5QlVfErBcFy_b4gN4tklrsoU1v9im6QCctsDMh4K3PqWMUALBjlo797X93Nqqeg-vEZ7I4fRF3jMcT5_6VE7JN0dxlDY</recordid><startdate>20050801</startdate><enddate>20050801</enddate><creator>Filler, Scott G.</creator><creator>Yeaman, Michael R.</creator><creator>Sheppard, Donald C.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7T7</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050801</creationdate><title>Tumor Necrosis Factor Inhibition and Invasive Fungal Infections</title><author>Filler, Scott G. ; 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| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2005-08, Vol.41 (Supplement-3), p.S208-S212 |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Aspergillosis Autoimmune diseases Candida albicans Drug therapy Endothelial cells Fungal infections Fungi Gangrene Humans Immunosuppressive Agents - adverse effects Infections Inhibitor drugs Leukocytes Medical treatment Mice Mycoses - immunology Neutrophils Opportunistic Infections - immunology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - physiology Tumor necrosis factors Tumors |
| title | Tumor Necrosis Factor Inhibition and Invasive Fungal Infections |
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