Effects of Cholesterol-Lowering Statins on the Aqueous Humor Outflow Pathway

To investigate the effects of cholesterol-lowering statin drugs on trabecular meshwork cellular properties and aqueous humor outflow. Primary cell cultures of porcine trabecular meshwork (PTM) and ciliary body (PCB) were treated with either lovastatin or compactin, to determine the effects of statin...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2005-07, Vol.46 (7), p.2424-2432
Hauptverfasser:	Song, Julia, Deng, Pei-Feng, Stinnett, Sandra S, Epstein, David L, Rao, P. Vasantha
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Anticholesteremic Agents - pharmacology Aqueous Humor - secretion Biological and medical sciences Blotting, Western Cell Shape - drug effects Cells, Cultured Ciliary Body - cytology Ciliary Body - drug effects Ciliary Body - metabolism Extracellular Matrix - metabolism Eye and associated structures. Visual pathways and centers. Vision Focal Adhesions - metabolism Fundamental and applied biological sciences. Psychology Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Lovastatin - pharmacology Myosin Light Chains - metabolism Organ Culture Techniques Phosphorylation rho GTP-Binding Proteins - metabolism Swine Trabecular Meshwork - cytology Trabecular Meshwork - drug effects Trabecular Meshwork - metabolism Vertebrates: nervous system and sense organs
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