DC-SIGN association with the Th2 environment of lepromatous lesions: cause or effect?

The clinical spectrum of leprosy is related to patients' immune responses. Non‐responsiveness towards Mycobacterium leprae (ML) seems to correlate with a Th2 cytokine profile. The reason for such a polarized immune response remains unclear. The C‐type lectin, DC‐SIGN, expressed by subsets of de...

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Veröffentlicht in:	The Journal of pathology 2006-06, Vol.209 (2), p.182-189
Hauptverfasser:	Soilleux, EJ, Sarno, EN, Hernandez, MO, Moseley, E, Horsley, J, Lopes, UG, Goddard, MJ, Vowler, SL, Coleman, N, Shattock, RJ, Sampaio, EP
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antigens, Bacterial - immunology Bacterial diseases Biological and medical sciences Cell Adhesion Molecules - immunology Cell Line Culture Media DC-SIGN Female HIV Seronegativity - immunology HIV Seropositivity - immunology Human bacterial diseases Human immunodeficiency virus Humans Infectious diseases Investigative techniques, diagnostic techniques (general aspects) Lectins, C-Type - immunology Leprosy Leprosy - immunology Leprosy, Borderline - immunology Leprosy, Tuberculoid - immunology Lipopolysaccharides - immunology M. leprae macrophage Macrophages - immunology Male ManLAM Medical sciences Middle Aged Mycobacterium Mycobacterium leprae Mycobacterium leprae - immunology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Cell Surface - immunology Th2 Cells - immunology Transfection - methods Tropical bacterial diseases
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