DC-SIGN association with the Th2 environment of lepromatous lesions: cause or effect?
The clinical spectrum of leprosy is related to patients' immune responses. Non‐responsiveness towards Mycobacterium leprae (ML) seems to correlate with a Th2 cytokine profile. The reason for such a polarized immune response remains unclear. The C‐type lectin, DC‐SIGN, expressed by subsets of de...
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| Veröffentlicht in: | The Journal of pathology 2006-06, Vol.209 (2), p.182-189 |
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| container_title | The Journal of pathology |
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| creator | Soilleux, EJ Sarno, EN Hernandez, MO Moseley, E Horsley, J Lopes, UG Goddard, MJ Vowler, SL Coleman, N Shattock, RJ Sampaio, EP |
| description | The clinical spectrum of leprosy is related to patients' immune responses. Non‐responsiveness towards Mycobacterium leprae (ML) seems to correlate with a Th2 cytokine profile. The reason for such a polarized immune response remains unclear. The C‐type lectin, DC‐SIGN, expressed by subsets of dendritic cells (DCs) and macrophages, has previously been associated with Th2 responses. Here we show abundant DC‐SIGN expression in lepromatous but not borderline tuberculoid leprosy, in both HIV‐positive and HIV‐negative patients. Moreover, we demonstrate that DC‐SIGN can act as an entry receptor for ML, as it does for M. tuberculosis, through the cell wall component lipoarabinomannan. DC‐SIGN is expressed on virtually all ML‐containing cells, providing further evidence for its role as a receptor. DC‐SIGN may therefore be induced on macrophages in lepromatous leprosy and may then contribute to mycobacterial entry into these cells. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/path.1972 |
| format | Article |
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Non‐responsiveness towards Mycobacterium leprae (ML) seems to correlate with a Th2 cytokine profile. The reason for such a polarized immune response remains unclear. The C‐type lectin, DC‐SIGN, expressed by subsets of dendritic cells (DCs) and macrophages, has previously been associated with Th2 responses. Here we show abundant DC‐SIGN expression in lepromatous but not borderline tuberculoid leprosy, in both HIV‐positive and HIV‐negative patients. Moreover, we demonstrate that DC‐SIGN can act as an entry receptor for ML, as it does for M. tuberculosis, through the cell wall component lipoarabinomannan. DC‐SIGN is expressed on virtually all ML‐containing cells, providing further evidence for its role as a receptor. DC‐SIGN may therefore be induced on macrophages in lepromatous leprosy and may then contribute to mycobacterial entry into these cells. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</description><identifier>ISSN: 0022-3417</identifier><identifier>EISSN: 1096-9896</identifier><identifier>DOI: 10.1002/path.1972</identifier><identifier>PMID: 16583355</identifier><identifier>CODEN: JPTLAS</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Adult ; Antigens, Bacterial - immunology ; Bacterial diseases ; Biological and medical sciences ; Cell Adhesion Molecules - immunology ; Cell Line ; Culture Media ; DC-SIGN ; Female ; HIV Seronegativity - immunology ; HIV Seropositivity - immunology ; Human bacterial diseases ; Human immunodeficiency virus ; Humans ; Infectious diseases ; Investigative techniques, diagnostic techniques (general aspects) ; Lectins, C-Type - immunology ; Leprosy ; Leprosy - immunology ; Leprosy, Borderline - immunology ; Leprosy, Tuberculoid - immunology ; Lipopolysaccharides - immunology ; M. leprae ; macrophage ; Macrophages - immunology ; Male ; ManLAM ; Medical sciences ; Middle Aged ; Mycobacterium ; Mycobacterium leprae ; Mycobacterium leprae - immunology ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - immunology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Receptors, Cell Surface - immunology ; Th2 Cells - immunology ; Transfection - methods ; Tropical bacterial diseases</subject><ispartof>The Journal of pathology, 2006-06, Vol.209 (2), p.182-189</ispartof><rights>Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</rights><rights>2006 INIST-CNRS</rights><rights>Copyright (c) 2006 Pathological Society of Great Britain and Ireland.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4222-f2c867ffc9a6b2ffbea13996e892cda2c9596f345cd205864a9295ce43d39d53</citedby><cites>FETCH-LOGICAL-c4222-f2c867ffc9a6b2ffbea13996e892cda2c9596f345cd205864a9295ce43d39d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpath.1972$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpath.1972$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17778534$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16583355$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Soilleux, EJ</creatorcontrib><creatorcontrib>Sarno, EN</creatorcontrib><creatorcontrib>Hernandez, MO</creatorcontrib><creatorcontrib>Moseley, E</creatorcontrib><creatorcontrib>Horsley, J</creatorcontrib><creatorcontrib>Lopes, UG</creatorcontrib><creatorcontrib>Goddard, MJ</creatorcontrib><creatorcontrib>Vowler, SL</creatorcontrib><creatorcontrib>Coleman, N</creatorcontrib><creatorcontrib>Shattock, RJ</creatorcontrib><creatorcontrib>Sampaio, EP</creatorcontrib><title>DC-SIGN association with the Th2 environment of lepromatous lesions: cause or effect?</title><title>The Journal of pathology</title><addtitle>J. Pathol</addtitle><description>The clinical spectrum of leprosy is related to patients' immune responses. Non‐responsiveness towards Mycobacterium leprae (ML) seems to correlate with a Th2 cytokine profile. The reason for such a polarized immune response remains unclear. The C‐type lectin, DC‐SIGN, expressed by subsets of dendritic cells (DCs) and macrophages, has previously been associated with Th2 responses. Here we show abundant DC‐SIGN expression in lepromatous but not borderline tuberculoid leprosy, in both HIV‐positive and HIV‐negative patients. Moreover, we demonstrate that DC‐SIGN can act as an entry receptor for ML, as it does for M. tuberculosis, through the cell wall component lipoarabinomannan. DC‐SIGN is expressed on virtually all ML‐containing cells, providing further evidence for its role as a receptor. DC‐SIGN may therefore be induced on macrophages in lepromatous leprosy and may then contribute to mycobacterial entry into these cells. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</description><subject>Adult</subject><subject>Antigens, Bacterial - immunology</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion Molecules - immunology</subject><subject>Cell Line</subject><subject>Culture Media</subject><subject>DC-SIGN</subject><subject>Female</subject><subject>HIV Seronegativity - immunology</subject><subject>HIV Seropositivity - immunology</subject><subject>Human bacterial diseases</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Lectins, C-Type - immunology</subject><subject>Leprosy</subject><subject>Leprosy - immunology</subject><subject>Leprosy, Borderline - immunology</subject><subject>Leprosy, Tuberculoid - immunology</subject><subject>Lipopolysaccharides - immunology</subject><subject>M. leprae</subject><subject>macrophage</subject><subject>Macrophages - immunology</subject><subject>Male</subject><subject>ManLAM</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycobacterium</subject><subject>Mycobacterium leprae</subject><subject>Mycobacterium leprae - immunology</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - immunology</subject><subject>Pathology. 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Pathol</addtitle><date>2006-06</date><risdate>2006</risdate><volume>209</volume><issue>2</issue><spage>182</spage><epage>189</epage><pages>182-189</pages><issn>0022-3417</issn><eissn>1096-9896</eissn><coden>JPTLAS</coden><abstract>The clinical spectrum of leprosy is related to patients' immune responses. Non‐responsiveness towards Mycobacterium leprae (ML) seems to correlate with a Th2 cytokine profile. The reason for such a polarized immune response remains unclear. The C‐type lectin, DC‐SIGN, expressed by subsets of dendritic cells (DCs) and macrophages, has previously been associated with Th2 responses. Here we show abundant DC‐SIGN expression in lepromatous but not borderline tuberculoid leprosy, in both HIV‐positive and HIV‐negative patients. Moreover, we demonstrate that DC‐SIGN can act as an entry receptor for ML, as it does for M. tuberculosis, through the cell wall component lipoarabinomannan. DC‐SIGN is expressed on virtually all ML‐containing cells, providing further evidence for its role as a receptor. DC‐SIGN may therefore be induced on macrophages in lepromatous leprosy and may then contribute to mycobacterial entry into these cells. Copyright © 2006 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>16583355</pmid><doi>10.1002/path.1972</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Antigens, Bacterial - immunology Bacterial diseases Biological and medical sciences Cell Adhesion Molecules - immunology Cell Line Culture Media DC-SIGN Female HIV Seronegativity - immunology HIV Seropositivity - immunology Human bacterial diseases Human immunodeficiency virus Humans Infectious diseases Investigative techniques, diagnostic techniques (general aspects) Lectins, C-Type - immunology Leprosy Leprosy - immunology Leprosy, Borderline - immunology Leprosy, Tuberculoid - immunology Lipopolysaccharides - immunology M. leprae macrophage Macrophages - immunology Male ManLAM Medical sciences Middle Aged Mycobacterium Mycobacterium leprae Mycobacterium leprae - immunology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Receptors, Cell Surface - immunology Th2 Cells - immunology Transfection - methods Tropical bacterial diseases |
| title | DC-SIGN association with the Th2 environment of lepromatous lesions: cause or effect? |
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