Magnetization transfer weighted imaging in the upper cervical spinal cord using cerebrospinal fluid as intersubject normalization reference (MTCSF imaging)
The magnetization transfer ratio (MTR) is a reliable measure of MT effects because it employs an internal standard that allows quantitative comparison between subjects, independent of other contrasts, coil loading, and coil sensitivity profiles. However, at very high spatial resolution in the spinal...
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| Veröffentlicht in: | Magnetic resonance in medicine 2005-07, Vol.54 (1), p.201-206 |
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| creator | Smith, Seth A. Xavier, Golay Ali, Fatemi Craig K., Jones Gerald V., Raymond Hugo W., Moser Peter C. M., van Zijl |
| description | The magnetization transfer ratio (MTR) is a reliable measure of MT effects because it employs an internal standard that allows quantitative comparison between subjects, independent of other contrasts, coil loading, and coil sensitivity profiles. However, at very high spatial resolution in the spinal cord at 1.5 T, the use of MTR quantification has been hampered by low signal‐to‐noise ratio (SNR) and acute sensitivity to motion. Here, the suitability of cerebrospinal fluid (CSF) as an alternative inter‐subject MT signal intensity reference for the spine is evaluated. Contrary to MTR, this so‐called MTCSF internal standard does not remove interfering T1, T2, and spin density contrast and is not expected to be able to discriminate between myelination and inflammation effects. However, it can detect initial changes in myelination when signal alterations are not yet detectable by conventional MRI. As a first example, this is demonstrated for the noninflammatory spinal cord white matter disease adrenomyeloneuropathy. Magn Reson Med 54:201–206, 2005. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mrm.20553 |
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M., van Zijl</creator><creatorcontrib>Smith, Seth A. ; Xavier, Golay ; Ali, Fatemi ; Craig K., Jones ; Gerald V., Raymond ; Hugo W., Moser ; Peter C. M., van Zijl</creatorcontrib><description>The magnetization transfer ratio (MTR) is a reliable measure of MT effects because it employs an internal standard that allows quantitative comparison between subjects, independent of other contrasts, coil loading, and coil sensitivity profiles. However, at very high spatial resolution in the spinal cord at 1.5 T, the use of MTR quantification has been hampered by low signal‐to‐noise ratio (SNR) and acute sensitivity to motion. Here, the suitability of cerebrospinal fluid (CSF) as an alternative inter‐subject MT signal intensity reference for the spine is evaluated. Contrary to MTR, this so‐called MTCSF internal standard does not remove interfering T1, T2, and spin density contrast and is not expected to be able to discriminate between myelination and inflammation effects. However, it can detect initial changes in myelination when signal alterations are not yet detectable by conventional MRI. As a first example, this is demonstrated for the noninflammatory spinal cord white matter disease adrenomyeloneuropathy. Magn Reson Med 54:201–206, 2005. © 2005 Wiley‐Liss, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.20553</identifier><identifier>PMID: 15968676</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adrenoleukodystrophy - pathology ; adrenomyeloneuropathy (AMN) ; Algorithms ; cerebrospinal fluid ; Cerebrospinal Fluid - cytology ; Cervical Vertebrae - pathology ; Humans ; Image Enhancement - methods ; Image Enhancement - standards ; Image Interpretation, Computer-Assisted - methods ; Image Interpretation, Computer-Assisted - standards ; Imaging, Three-Dimensional - methods ; Imaging, Three-Dimensional - standards ; Information Storage and Retrieval - methods ; Magnetic Resonance Imaging - methods ; Magnetic Resonance Imaging - standards ; magnetization transfer ; MRI ; Pattern Recognition, Automated - methods ; Reference Values ; Reproducibility of Results ; Sensitivity and Specificity ; spinal cord</subject><ispartof>Magnetic resonance in medicine, 2005-07, Vol.54 (1), p.201-206</ispartof><rights>Copyright © 2005 Wiley‐Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3923-274ff9072b47dbdcef150ec360a26d81a6589eda851eb4574cad03ef56c843013</citedby><cites>FETCH-LOGICAL-c3923-274ff9072b47dbdcef150ec360a26d81a6589eda851eb4574cad03ef56c843013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.20553$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.20553$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,1428,27905,27906,45555,45556,46390,46814</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15968676$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Seth A.</creatorcontrib><creatorcontrib>Xavier, Golay</creatorcontrib><creatorcontrib>Ali, Fatemi</creatorcontrib><creatorcontrib>Craig K., Jones</creatorcontrib><creatorcontrib>Gerald V., Raymond</creatorcontrib><creatorcontrib>Hugo W., Moser</creatorcontrib><creatorcontrib>Peter C. M., van Zijl</creatorcontrib><title>Magnetization transfer weighted imaging in the upper cervical spinal cord using cerebrospinal fluid as intersubject normalization reference (MTCSF imaging)</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>The magnetization transfer ratio (MTR) is a reliable measure of MT effects because it employs an internal standard that allows quantitative comparison between subjects, independent of other contrasts, coil loading, and coil sensitivity profiles. However, at very high spatial resolution in the spinal cord at 1.5 T, the use of MTR quantification has been hampered by low signal‐to‐noise ratio (SNR) and acute sensitivity to motion. Here, the suitability of cerebrospinal fluid (CSF) as an alternative inter‐subject MT signal intensity reference for the spine is evaluated. Contrary to MTR, this so‐called MTCSF internal standard does not remove interfering T1, T2, and spin density contrast and is not expected to be able to discriminate between myelination and inflammation effects. However, it can detect initial changes in myelination when signal alterations are not yet detectable by conventional MRI. As a first example, this is demonstrated for the noninflammatory spinal cord white matter disease adrenomyeloneuropathy. Magn Reson Med 54:201–206, 2005. © 2005 Wiley‐Liss, Inc.</description><subject>Adrenoleukodystrophy - pathology</subject><subject>adrenomyeloneuropathy (AMN)</subject><subject>Algorithms</subject><subject>cerebrospinal fluid</subject><subject>Cerebrospinal Fluid - cytology</subject><subject>Cervical Vertebrae - pathology</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Image Enhancement - standards</subject><subject>Image Interpretation, Computer-Assisted - methods</subject><subject>Image Interpretation, Computer-Assisted - standards</subject><subject>Imaging, Three-Dimensional - methods</subject><subject>Imaging, Three-Dimensional - standards</subject><subject>Information Storage and Retrieval - methods</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Magnetic Resonance Imaging - standards</subject><subject>magnetization transfer</subject><subject>MRI</subject><subject>Pattern Recognition, Automated - methods</subject><subject>Reference Values</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>spinal cord</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctuFDEQRS0EIkPCgh9AXiGy6MRuv9pLNCIPKRPQJFHYWW539cShX9jdhORX-FkcZgZWUVa1uOfeUtVF6B0lB5SQ_LAN7UFOhGAv0IyKPM9yoflLNCOKk4xRzXfQmxhvCSFaK_4a7VChZSGVnKHfC7vqYPQPdvR9h8dgu1hDwHfgVzcjVNi3duW7FfZJvAE8DUNSHYSf3tkGx8F3abg-VHiKj1ySoAz9RqibyVfYxmQfIcSpvAU34q4PrW22OwOkhdA5wB8Xl_OLo-3K_T30qrZNhLebuYuujj5fzk-ysy_Hp_NPZ5ljOmdZrnhda6LykquqrBzUVBBwTBKby6qgVopCQ2ULQaHkQnFnK8KgFtIVnBHKdtGHde4Q-h8TxNG0PjpoGttBP0UjlVaSF8-D6dOUMl0kcH8NuvSJmA40Q0hXhXtDiXmszKTKzN_KEvt-EzqVLVT_yU1HCThcA3e-gfunk8xiudhGZmuHjyP8-uew4Xu6hSlhrs-Pjfp2svx6vbww5-wPVyKzTQ</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Smith, Seth A.</creator><creator>Xavier, Golay</creator><creator>Ali, Fatemi</creator><creator>Craig K., Jones</creator><creator>Gerald V., Raymond</creator><creator>Hugo W., Moser</creator><creator>Peter C. M., van Zijl</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>200507</creationdate><title>Magnetization transfer weighted imaging in the upper cervical spinal cord using cerebrospinal fluid as intersubject normalization reference (MTCSF imaging)</title><author>Smith, Seth A. ; Xavier, Golay ; Ali, Fatemi ; Craig K., Jones ; Gerald V., Raymond ; Hugo W., Moser ; Peter C. M., van Zijl</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3923-274ff9072b47dbdcef150ec360a26d81a6589eda851eb4574cad03ef56c843013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Adrenoleukodystrophy - pathology</topic><topic>adrenomyeloneuropathy (AMN)</topic><topic>Algorithms</topic><topic>cerebrospinal fluid</topic><topic>Cerebrospinal Fluid - cytology</topic><topic>Cervical Vertebrae - pathology</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Image Enhancement - standards</topic><topic>Image Interpretation, Computer-Assisted - methods</topic><topic>Image Interpretation, Computer-Assisted - standards</topic><topic>Imaging, Three-Dimensional - methods</topic><topic>Imaging, Three-Dimensional - standards</topic><topic>Information Storage and Retrieval - methods</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Magnetic Resonance Imaging - standards</topic><topic>magnetization transfer</topic><topic>MRI</topic><topic>Pattern Recognition, Automated - methods</topic><topic>Reference Values</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>spinal cord</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Seth A.</creatorcontrib><creatorcontrib>Xavier, Golay</creatorcontrib><creatorcontrib>Ali, Fatemi</creatorcontrib><creatorcontrib>Craig K., Jones</creatorcontrib><creatorcontrib>Gerald V., Raymond</creatorcontrib><creatorcontrib>Hugo W., Moser</creatorcontrib><creatorcontrib>Peter C. 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M., van Zijl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetization transfer weighted imaging in the upper cervical spinal cord using cerebrospinal fluid as intersubject normalization reference (MTCSF imaging)</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2005-07</date><risdate>2005</risdate><volume>54</volume><issue>1</issue><spage>201</spage><epage>206</epage><pages>201-206</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>The magnetization transfer ratio (MTR) is a reliable measure of MT effects because it employs an internal standard that allows quantitative comparison between subjects, independent of other contrasts, coil loading, and coil sensitivity profiles. However, at very high spatial resolution in the spinal cord at 1.5 T, the use of MTR quantification has been hampered by low signal‐to‐noise ratio (SNR) and acute sensitivity to motion. Here, the suitability of cerebrospinal fluid (CSF) as an alternative inter‐subject MT signal intensity reference for the spine is evaluated. Contrary to MTR, this so‐called MTCSF internal standard does not remove interfering T1, T2, and spin density contrast and is not expected to be able to discriminate between myelination and inflammation effects. However, it can detect initial changes in myelination when signal alterations are not yet detectable by conventional MRI. As a first example, this is demonstrated for the noninflammatory spinal cord white matter disease adrenomyeloneuropathy. Magn Reson Med 54:201–206, 2005. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15968676</pmid><doi>10.1002/mrm.20553</doi><tpages>6</tpages></addata></record> |
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| subjects | Adrenoleukodystrophy - pathology adrenomyeloneuropathy (AMN) Algorithms cerebrospinal fluid Cerebrospinal Fluid - cytology Cervical Vertebrae - pathology Humans Image Enhancement - methods Image Enhancement - standards Image Interpretation, Computer-Assisted - methods Image Interpretation, Computer-Assisted - standards Imaging, Three-Dimensional - methods Imaging, Three-Dimensional - standards Information Storage and Retrieval - methods Magnetic Resonance Imaging - methods Magnetic Resonance Imaging - standards magnetization transfer MRI Pattern Recognition, Automated - methods Reference Values Reproducibility of Results Sensitivity and Specificity spinal cord |
| title | Magnetization transfer weighted imaging in the upper cervical spinal cord using cerebrospinal fluid as intersubject normalization reference (MTCSF imaging) |
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