Induction of Epidermolysis Bullosa Acquisita in Mice by Passive Transfer of Autoantibodies from Patients

Epidermolysis bullosa acquisita (EBA) is an autoimmune sub-epidermal blistering disease characterized by autoantibodies to type VII (anchoring fibril) collagen. To date, however, direct evidence for a pathogenic role of human EBA autoantibodies has not been demonstrated. In this study, we affinity-p...

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Veröffentlicht in:	Journal of investigative dermatology 2006-06, Vol.126 (6), p.1323-1330
Hauptverfasser:	Woodley, David T., Ram, Ramin, Doostan, Arvin, Bandyopadhyay, Pubali, Huang, Yi, Remington, Jennifer, Hou, Yingping, Keene, Douglas R., Liu, Zhi, Chen, Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies - immunology Biological and medical sciences Bullous diseases of the skin Collagen Type VII - immunology Complement C3 - analysis Dermatology Disease Models, Animal Epidermolysis Bullosa Acquisita - immunology Epidermolysis Bullosa Acquisita - pathology Humans Immunoglobulin Fab Fragments - immunology Immunoglobulin G - analysis Medical sciences Mice - immunology Microscopy, Immunoelectron Skin - immunology Skin - pathology Skin - ultrastructure
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