Detection of cardiac sarcoidosis using cardiac markers and myocardial integrated backscatter
It is not known whether cardiac markers and cyclic variations of integrated backscatter can be used to detect cardiac sarcoidosis. We studied 62 patients with sarcoidosis affecting the lung, eyes, skin, or heart (27 patients with cardiac involvement and 35 patients without). The cyclic variation of...
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| Veröffentlicht in: | International journal of cardiology 2005-07, Vol.102 (2), p.259-268 |
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| container_title | International journal of cardiology |
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| creator | Yasutake, Hiroko Seino, Yoshihiko Kashiwagi, Mutsumi Honma, Hiroshi Matsuzaki, Tsuyako Takano, Teruo |
| description | It is not known whether cardiac markers and cyclic variations of integrated backscatter can be used to detect cardiac sarcoidosis.
We studied 62 patients with sarcoidosis affecting the lung, eyes, skin, or heart (27 patients with cardiac involvement and 35 patients without). The cyclic variation of integrated backscatter and wall thickening was evaluated in the left ventricular anterior septum and posterior wall. Plasma A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) concentrations and serum cardiac troponin T were also determined.
Plasma natriuretic peptide concentrations were higher in the cardiac involvement group (ANP: 15.5 [interquartile range (IQR) 2.5–34.0] vs. 12.0 [10.0–16.5] pg/ml,
P=0.25; BNP: 28.6 [5.9–141] vs. 10.1 [4.8–15.4] pg/ml,
P=0.049). However, cardiac troponin T concentration was |
| doi_str_mv | 10.1016/j.ijcard.2004.05.028 |
| format | Article |
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We studied 62 patients with sarcoidosis affecting the lung, eyes, skin, or heart (27 patients with cardiac involvement and 35 patients without). The cyclic variation of integrated backscatter and wall thickening was evaluated in the left ventricular anterior septum and posterior wall. Plasma A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) concentrations and serum cardiac troponin T were also determined.
Plasma natriuretic peptide concentrations were higher in the cardiac involvement group (ANP: 15.5 [interquartile range (IQR) 2.5–34.0] vs. 12.0 [10.0–16.5] pg/ml,
P=0.25; BNP: 28.6 [5.9–141] vs. 10.1 [4.8–15.4] pg/ml,
P=0.049). However, cardiac troponin T concentration was <0.01 ng/ml in all patients. Receiver–operator characteristic (ROC) analysis showed that both ANP and BNP could identify patients with high-degree atrioventricular block, ventricular tachyarrhythmias, or symptomatic heart failure (the areas under the ROC curve were 0.94 and 0.97, respectively). The cardiac involvement group could be distinguished from the noninvolvement group by combining cutoff values for the magnitude of integrated backscatter cyclic variation (5.5 dB) and wall thickening (30%), albeit only for the posterior wall.
Both ANP and BNP are useful markers for identifying patients with sarcoidosis and cardiac complication(s). Moreover, evaluation of integrated backscatter cyclic variation combined with wall thickening may be of help in detecting cardiac involvement in the posterior wall.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2004.05.028</identifier><identifier>PMID: 15982494</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Atrial Natriuretic Factor - blood ; Biological and medical sciences ; Biomarkers - blood ; Cardiac sarcoidosis ; Cardiology. Vascular system ; Cardiomyopathies - blood ; Cardiomyopathies - diagnosis ; Echocardiography ; Female ; Follow-Up Studies ; Gated Blood-Pool Imaging ; Heart Ventricles - diagnostic imaging ; Humans ; Integrated backscatter ; Male ; Medical sciences ; Middle Aged ; Natriuretic peptide ; Natriuretic Peptide, Brain - blood ; Retrospective Studies ; ROC Curve ; Sarcoidosis - blood ; Sarcoidosis - diagnosis ; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis ; Severity of Illness Index ; Troponin T - blood</subject><ispartof>International journal of cardiology, 2005-07, Vol.102 (2), p.259-268</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-a2703feb13887b6b86aaa9123f6a8e7374b0f50d958d503ddca57cc4768ebf0e3</citedby><cites>FETCH-LOGICAL-c456t-a2703feb13887b6b86aaa9123f6a8e7374b0f50d958d503ddca57cc4768ebf0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2004.05.028$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16915709$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15982494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yasutake, Hiroko</creatorcontrib><creatorcontrib>Seino, Yoshihiko</creatorcontrib><creatorcontrib>Kashiwagi, Mutsumi</creatorcontrib><creatorcontrib>Honma, Hiroshi</creatorcontrib><creatorcontrib>Matsuzaki, Tsuyako</creatorcontrib><creatorcontrib>Takano, Teruo</creatorcontrib><title>Detection of cardiac sarcoidosis using cardiac markers and myocardial integrated backscatter</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>It is not known whether cardiac markers and cyclic variations of integrated backscatter can be used to detect cardiac sarcoidosis.
We studied 62 patients with sarcoidosis affecting the lung, eyes, skin, or heart (27 patients with cardiac involvement and 35 patients without). The cyclic variation of integrated backscatter and wall thickening was evaluated in the left ventricular anterior septum and posterior wall. Plasma A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) concentrations and serum cardiac troponin T were also determined.
Plasma natriuretic peptide concentrations were higher in the cardiac involvement group (ANP: 15.5 [interquartile range (IQR) 2.5–34.0] vs. 12.0 [10.0–16.5] pg/ml,
P=0.25; BNP: 28.6 [5.9–141] vs. 10.1 [4.8–15.4] pg/ml,
P=0.049). However, cardiac troponin T concentration was <0.01 ng/ml in all patients. Receiver–operator characteristic (ROC) analysis showed that both ANP and BNP could identify patients with high-degree atrioventricular block, ventricular tachyarrhythmias, or symptomatic heart failure (the areas under the ROC curve were 0.94 and 0.97, respectively). The cardiac involvement group could be distinguished from the noninvolvement group by combining cutoff values for the magnitude of integrated backscatter cyclic variation (5.5 dB) and wall thickening (30%), albeit only for the posterior wall.
Both ANP and BNP are useful markers for identifying patients with sarcoidosis and cardiac complication(s). Moreover, evaluation of integrated backscatter cyclic variation combined with wall thickening may be of help in detecting cardiac involvement in the posterior wall.</description><subject>Atrial Natriuretic Factor - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiac sarcoidosis</subject><subject>Cardiology. Vascular system</subject><subject>Cardiomyopathies - blood</subject><subject>Cardiomyopathies - diagnosis</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gated Blood-Pool Imaging</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Humans</subject><subject>Integrated backscatter</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Natriuretic peptide</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Sarcoidosis - blood</subject><subject>Sarcoidosis - diagnosis</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>Severity of Illness Index</subject><subject>Troponin T - blood</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1r3DAQhkVJaLZp_0EpviQ3O5Ktz0uh5KMNBHJpbwUxlsaLdr1WInkD-ffV4iW59SQYPfMy8wwhXxltGGXyatOEjYPkm5ZS3lDR0FZ_ICumFa-ZEvyErAqmatGq7ox8ynlDC2iM_kjOmDC65YavyN8bnNHNIU5VHKpDXgBXZUguBh9zyNU-h2n99rODtMWUK5h8tXuNS3mswjTjOsGMvurBbbODecb0mZwOMGb8cnzPyZ-729_Xv-qHx5_31z8easeFnGtoFe0G7FmnteplryUAGNZ2gwSNqlO8p4Og3gjtBe28dyCUc1xJjf1AsTsnl0vuU4rPe8yz3YXscBxhwrjPViqjhJaygHwBXYo5JxzsUwplpVfLqD1YtRu7WLUHq5YKW6yWtm_H_H2_Q__edNRYgIsjAGX1cUgwuZDfOWmYUNQU7vvCYbHxEjDZ7AJODn1I5QrWx_D_Sf4BxeCZBw</recordid><startdate>20050710</startdate><enddate>20050710</enddate><creator>Yasutake, Hiroko</creator><creator>Seino, Yoshihiko</creator><creator>Kashiwagi, Mutsumi</creator><creator>Honma, Hiroshi</creator><creator>Matsuzaki, Tsuyako</creator><creator>Takano, Teruo</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050710</creationdate><title>Detection of cardiac sarcoidosis using cardiac markers and myocardial integrated backscatter</title><author>Yasutake, Hiroko ; Seino, Yoshihiko ; Kashiwagi, Mutsumi ; Honma, Hiroshi ; Matsuzaki, Tsuyako ; Takano, Teruo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-a2703feb13887b6b86aaa9123f6a8e7374b0f50d958d503ddca57cc4768ebf0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Atrial Natriuretic Factor - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiac sarcoidosis</topic><topic>Cardiology. Vascular system</topic><topic>Cardiomyopathies - blood</topic><topic>Cardiomyopathies - diagnosis</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gated Blood-Pool Imaging</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Humans</topic><topic>Integrated backscatter</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Natriuretic peptide</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Sarcoidosis - blood</topic><topic>Sarcoidosis - diagnosis</topic><topic>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>Severity of Illness Index</topic><topic>Troponin T - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yasutake, Hiroko</creatorcontrib><creatorcontrib>Seino, Yoshihiko</creatorcontrib><creatorcontrib>Kashiwagi, Mutsumi</creatorcontrib><creatorcontrib>Honma, Hiroshi</creatorcontrib><creatorcontrib>Matsuzaki, Tsuyako</creatorcontrib><creatorcontrib>Takano, Teruo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yasutake, Hiroko</au><au>Seino, Yoshihiko</au><au>Kashiwagi, Mutsumi</au><au>Honma, Hiroshi</au><au>Matsuzaki, Tsuyako</au><au>Takano, Teruo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of cardiac sarcoidosis using cardiac markers and myocardial integrated backscatter</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2005-07-10</date><risdate>2005</risdate><volume>102</volume><issue>2</issue><spage>259</spage><epage>268</epage><pages>259-268</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>It is not known whether cardiac markers and cyclic variations of integrated backscatter can be used to detect cardiac sarcoidosis.
We studied 62 patients with sarcoidosis affecting the lung, eyes, skin, or heart (27 patients with cardiac involvement and 35 patients without). The cyclic variation of integrated backscatter and wall thickening was evaluated in the left ventricular anterior septum and posterior wall. Plasma A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) concentrations and serum cardiac troponin T were also determined.
Plasma natriuretic peptide concentrations were higher in the cardiac involvement group (ANP: 15.5 [interquartile range (IQR) 2.5–34.0] vs. 12.0 [10.0–16.5] pg/ml,
P=0.25; BNP: 28.6 [5.9–141] vs. 10.1 [4.8–15.4] pg/ml,
P=0.049). However, cardiac troponin T concentration was <0.01 ng/ml in all patients. Receiver–operator characteristic (ROC) analysis showed that both ANP and BNP could identify patients with high-degree atrioventricular block, ventricular tachyarrhythmias, or symptomatic heart failure (the areas under the ROC curve were 0.94 and 0.97, respectively). The cardiac involvement group could be distinguished from the noninvolvement group by combining cutoff values for the magnitude of integrated backscatter cyclic variation (5.5 dB) and wall thickening (30%), albeit only for the posterior wall.
Both ANP and BNP are useful markers for identifying patients with sarcoidosis and cardiac complication(s). Moreover, evaluation of integrated backscatter cyclic variation combined with wall thickening may be of help in detecting cardiac involvement in the posterior wall.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15982494</pmid><doi>10.1016/j.ijcard.2004.05.028</doi><tpages>10</tpages></addata></record> |
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| subjects | Atrial Natriuretic Factor - blood Biological and medical sciences Biomarkers - blood Cardiac sarcoidosis Cardiology. Vascular system Cardiomyopathies - blood Cardiomyopathies - diagnosis Echocardiography Female Follow-Up Studies Gated Blood-Pool Imaging Heart Ventricles - diagnostic imaging Humans Integrated backscatter Male Medical sciences Middle Aged Natriuretic peptide Natriuretic Peptide, Brain - blood Retrospective Studies ROC Curve Sarcoidosis - blood Sarcoidosis - diagnosis Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Severity of Illness Index Troponin T - blood |
| title | Detection of cardiac sarcoidosis using cardiac markers and myocardial integrated backscatter |
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