Spontaneous regression of intraoral mucosa‐associated lymphoid tissue lymphoma: Molecular study of a case
Mucosa‐associated lymphoid tissue (MALT) lymphoma presentation in the oral cavity is very rare. Reported herein is a case of intraoral MALT lymphoma of the minor salivary gland in a 70‐year‐old woman with Sjogren’s syndrome. Unexpectedly, a spontaneous clinically and histologically confirmed regress...
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| Veröffentlicht in: | Pathology international 2006-06, Vol.56 (6), p.331-335 |
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| creator | Sakuma, Hidenori Okabe, Mitsukuni Yokoi, Motoo Eimoto, Tadaaki Inagaki, Hiroshi |
| description | Mucosa‐associated lymphoid tissue (MALT) lymphoma presentation in the oral cavity is very rare. Reported herein is a case of intraoral MALT lymphoma of the minor salivary gland in a 70‐year‐old woman with Sjogren’s syndrome. Unexpectedly, a spontaneous clinically and histologically confirmed regression occurred 1 month after the tumor biopsy for diagnosis. Considering that salivary MALT lymphoma is associated with Sjogren’s syndrome and that the chronic inflammation caused by Sjogren’s syndrome persisted, it is hypothesized that the tumor clone might be present in the regressed lesion. Minimal residual tumor clone identical with the primary lesion was detected using the polymerase chain reaction (PCR) clonality assay for immunoglobulin heavy chain gene (IgH) rearrangement. No recurrence was clinically evident 38 months after the diagnosis. Spontaneous regression of MALT lymphoma should be examined at the molecular level in addition to clinical and histological evaluations. When minimal residual disease is detected, close follow up is necessary for early detection of the tumor relapse. |
| doi_str_mv | 10.1111/j.1440-1827.2006.01967.x |
| format | Article |
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Reported herein is a case of intraoral MALT lymphoma of the minor salivary gland in a 70‐year‐old woman with Sjogren’s syndrome. Unexpectedly, a spontaneous clinically and histologically confirmed regression occurred 1 month after the tumor biopsy for diagnosis. Considering that salivary MALT lymphoma is associated with Sjogren’s syndrome and that the chronic inflammation caused by Sjogren’s syndrome persisted, it is hypothesized that the tumor clone might be present in the regressed lesion. Minimal residual tumor clone identical with the primary lesion was detected using the polymerase chain reaction (PCR) clonality assay for immunoglobulin heavy chain gene (IgH) rearrangement. No recurrence was clinically evident 38 months after the diagnosis. Spontaneous regression of MALT lymphoma should be examined at the molecular level in addition to clinical and histological evaluations. 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Reported herein is a case of intraoral MALT lymphoma of the minor salivary gland in a 70‐year‐old woman with Sjogren’s syndrome. Unexpectedly, a spontaneous clinically and histologically confirmed regression occurred 1 month after the tumor biopsy for diagnosis. Considering that salivary MALT lymphoma is associated with Sjogren’s syndrome and that the chronic inflammation caused by Sjogren’s syndrome persisted, it is hypothesized that the tumor clone might be present in the regressed lesion. Minimal residual tumor clone identical with the primary lesion was detected using the polymerase chain reaction (PCR) clonality assay for immunoglobulin heavy chain gene (IgH) rearrangement. No recurrence was clinically evident 38 months after the diagnosis. Spontaneous regression of MALT lymphoma should be examined at the molecular level in addition to clinical and histological evaluations. When minimal residual disease is detected, close follow up is necessary for early detection of the tumor relapse.</description><subject>Aged</subject><subject>Clone Cells - pathology</subject><subject>DNA, Neoplasm - analysis</subject><subject>Female</subject><subject>Gene Rearrangement, B-Lymphocyte, Heavy Chain - genetics</subject><subject>Gene Rearrangement, B-Lymphocyte, Heavy Chain - immunology</subject><subject>Humans</subject><subject>Lymphoma, B-Cell, Marginal Zone - genetics</subject><subject>Lymphoma, B-Cell, Marginal Zone - immunology</subject><subject>Lymphoma, B-Cell, Marginal Zone - pathology</subject><subject>minimal residual disease</subject><subject>mucosa‐associated lymphoid tissue lymphoma</subject><subject>Neoplasm Regression, Spontaneous - genetics</subject><subject>Neoplasm Regression, Spontaneous - immunology</subject><subject>Neoplasm Regression, Spontaneous - pathology</subject><subject>Neoplasm, Residual - genetics</subject><subject>Neoplasm, Residual - immunology</subject><subject>Neoplasm, Residual - pathology</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>oral cavity</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Salivary Gland Neoplasms - genetics</subject><subject>Salivary Gland Neoplasms - immunology</subject><subject>Salivary Gland Neoplasms - pathology</subject><subject>Salivary Glands, Minor - immunology</subject><subject>Salivary Glands, Minor - pathology</subject><subject>Sjogren’s syndrome</subject><subject>spontaneous regression</subject><issn>1320-5463</issn><issn>1440-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkEtOwzAQhi0EoqVwBeQVuwQ7ce0YiQVCPCqVhwSsLcdxICWJiycR7Y4jcEZOQkIq2DKbmdH884_mQwhTEtIujhchZYwENIlEGBHCQ0IlF-FqC41_B9tdHUckmDIej9AewIIQKmJOdtGIckEYk2KMXh-Wrm50bV0L2NtnbwEKV2OX46JuvHZel7hqjQP99fGpAZwpdGMzXK6r5YsrMtwUAK3d9JU-wTeutKYttcfQtNm6t9LYaLD7aCfXJdiDTZ6gp8uLx_PrYH53NTs_mweGJVwEqZFJKhOWxJnMWWolo3nEeGakFlFGoym1hpCIspQnkhpNpRRpJKZcp7x7kMQTdDT4Lr17ay00qirA2LIc3lRcSDEVlHbCZBAa7wC8zdXSF5X2a0WJ6kGrhep5qp6n6kGrH9Bq1a0ebm60aWWzv8UN2U5wOgjei9Ku_22s7me3fRV_A_rvjq0</recordid><startdate>200606</startdate><enddate>200606</enddate><creator>Sakuma, Hidenori</creator><creator>Okabe, Mitsukuni</creator><creator>Yokoi, Motoo</creator><creator>Eimoto, Tadaaki</creator><creator>Inagaki, Hiroshi</creator><general>Blackwell Publishing Asia</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200606</creationdate><title>Spontaneous regression of intraoral mucosa‐associated lymphoid tissue lymphoma: Molecular study of a case</title><author>Sakuma, Hidenori ; Okabe, Mitsukuni ; Yokoi, Motoo ; Eimoto, Tadaaki ; Inagaki, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4867-bc98b98483d9f4be941f246dc9a72d1251ec00214b6891ca1997b2756ab617303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Aged</topic><topic>Clone Cells - pathology</topic><topic>DNA, Neoplasm - analysis</topic><topic>Female</topic><topic>Gene Rearrangement, B-Lymphocyte, Heavy Chain - genetics</topic><topic>Gene Rearrangement, B-Lymphocyte, Heavy Chain - immunology</topic><topic>Humans</topic><topic>Lymphoma, B-Cell, Marginal Zone - genetics</topic><topic>Lymphoma, B-Cell, Marginal Zone - immunology</topic><topic>Lymphoma, B-Cell, Marginal Zone - pathology</topic><topic>minimal residual disease</topic><topic>mucosa‐associated lymphoid tissue lymphoma</topic><topic>Neoplasm Regression, Spontaneous - genetics</topic><topic>Neoplasm Regression, Spontaneous - immunology</topic><topic>Neoplasm Regression, Spontaneous - pathology</topic><topic>Neoplasm, Residual - genetics</topic><topic>Neoplasm, Residual - immunology</topic><topic>Neoplasm, Residual - pathology</topic><topic>Oncogene Proteins, Fusion - genetics</topic><topic>oral cavity</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>Salivary Gland Neoplasms - genetics</topic><topic>Salivary Gland Neoplasms - immunology</topic><topic>Salivary Gland Neoplasms - pathology</topic><topic>Salivary Glands, Minor - immunology</topic><topic>Salivary Glands, Minor - pathology</topic><topic>Sjogren’s syndrome</topic><topic>spontaneous regression</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sakuma, Hidenori</creatorcontrib><creatorcontrib>Okabe, Mitsukuni</creatorcontrib><creatorcontrib>Yokoi, Motoo</creatorcontrib><creatorcontrib>Eimoto, Tadaaki</creatorcontrib><creatorcontrib>Inagaki, Hiroshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sakuma, Hidenori</au><au>Okabe, Mitsukuni</au><au>Yokoi, Motoo</au><au>Eimoto, Tadaaki</au><au>Inagaki, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous regression of intraoral mucosa‐associated lymphoid tissue lymphoma: Molecular study of a case</atitle><jtitle>Pathology international</jtitle><addtitle>Pathol Int</addtitle><date>2006-06</date><risdate>2006</risdate><volume>56</volume><issue>6</issue><spage>331</spage><epage>335</epage><pages>331-335</pages><issn>1320-5463</issn><eissn>1440-1827</eissn><abstract>Mucosa‐associated lymphoid tissue (MALT) lymphoma presentation in the oral cavity is very rare. Reported herein is a case of intraoral MALT lymphoma of the minor salivary gland in a 70‐year‐old woman with Sjogren’s syndrome. Unexpectedly, a spontaneous clinically and histologically confirmed regression occurred 1 month after the tumor biopsy for diagnosis. Considering that salivary MALT lymphoma is associated with Sjogren’s syndrome and that the chronic inflammation caused by Sjogren’s syndrome persisted, it is hypothesized that the tumor clone might be present in the regressed lesion. Minimal residual tumor clone identical with the primary lesion was detected using the polymerase chain reaction (PCR) clonality assay for immunoglobulin heavy chain gene (IgH) rearrangement. No recurrence was clinically evident 38 months after the diagnosis. Spontaneous regression of MALT lymphoma should be examined at the molecular level in addition to clinical and histological evaluations. 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| subjects | Aged Clone Cells - pathology DNA, Neoplasm - analysis Female Gene Rearrangement, B-Lymphocyte, Heavy Chain - genetics Gene Rearrangement, B-Lymphocyte, Heavy Chain - immunology Humans Lymphoma, B-Cell, Marginal Zone - genetics Lymphoma, B-Cell, Marginal Zone - immunology Lymphoma, B-Cell, Marginal Zone - pathology minimal residual disease mucosa‐associated lymphoid tissue lymphoma Neoplasm Regression, Spontaneous - genetics Neoplasm Regression, Spontaneous - immunology Neoplasm Regression, Spontaneous - pathology Neoplasm, Residual - genetics Neoplasm, Residual - immunology Neoplasm, Residual - pathology Oncogene Proteins, Fusion - genetics oral cavity Reverse Transcriptase Polymerase Chain Reaction Salivary Gland Neoplasms - genetics Salivary Gland Neoplasms - immunology Salivary Gland Neoplasms - pathology Salivary Glands, Minor - immunology Salivary Glands, Minor - pathology Sjogren’s syndrome spontaneous regression |
| title | Spontaneous regression of intraoral mucosa‐associated lymphoid tissue lymphoma: Molecular study of a case |
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