Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis
This study aimed to investigate whether fluid shifts alter ciprofloxacin pharmacokinetics in critically ill patients over time. Patients ≥18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with do...
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| Veröffentlicht in: | International journal of antimicrobial agents 2005-07, Vol.26 (1), p.50-55 |
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| container_title | International journal of antimicrobial agents |
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| creator | Gous, Andries Lipman, Jeffrey Scribante, Juan Tshukutsoane, Shephelia Hon, Hubert Pinder, Mary Mathivha, Rudo Verhoef, Lia Stass, Heino |
| description | This study aimed to investigate whether fluid shifts alter ciprofloxacin pharmacokinetics in critically ill patients over time. Patients ≥18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with documented intra-abdominal infections. Group B (18 patients) included patients with severe sepsis from other causes. All patients received intravenous ciprofloxacin 400
mg every 8
h infused over 60
min. Eight timed blood specimens were taken on days 0, 2 and 7. Ciprofloxacin plasma concentrations were determined using high performance liquid chromatography. There were no significant differences between the pharmacokinetics of the two groups or over time. Ciprofloxacin pharmacokinetics in critically ill patients do not change over time, and intra-abdominal sepsis does not alter ciprofloxacin pharmacokinetic parameters to a greater degree than sepsis from other causes in critically ill patients. |
| doi_str_mv | 10.1016/j.ijantimicag.2005.04.005 |
| format | Article |
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mg every 8
h infused over 60
min. Eight timed blood specimens were taken on days 0, 2 and 7. Ciprofloxacin plasma concentrations were determined using high performance liquid chromatography. There were no significant differences between the pharmacokinetics of the two groups or over time. Ciprofloxacin pharmacokinetics in critically ill patients do not change over time, and intra-abdominal sepsis does not alter ciprofloxacin pharmacokinetic parameters to a greater degree than sepsis from other causes in critically ill patients.</description><identifier>ISSN: 0924-8579</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/j.ijantimicag.2005.04.005</identifier><identifier>PMID: 15955670</identifier><language>eng</language><publisher>London: Elsevier B.V</publisher><subject>Adolescent ; Adult ; Anti-Bacterial Agents - pharmacokinetics ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacterial Infections - drug therapy ; Biological and medical sciences ; Body Fluid Compartments - physiology ; Ciprofloxacin - pharmacokinetics ; Ciprofloxacin - therapeutic use ; Female ; Fluoroquinolone ; Humans ; Intensive Care Unit ; Intensive Care Units ; Male ; Medical sciences ; Middle Aged ; Pharmacokinetics ; Pharmacology. Drug treatments ; Sepsis - drug therapy ; Volume of distribution</subject><ispartof>International journal of antimicrobial agents, 2005-07, Vol.26 (1), p.50-55</ispartof><rights>2005 Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-f71ccff9d573695a78269853f147ec464ff144abd9cf3e8310751ff1e17183723</citedby><cites>FETCH-LOGICAL-c382t-f71ccff9d573695a78269853f147ec464ff144abd9cf3e8310751ff1e17183723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0924857905001196$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16926597$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15955670$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gous, Andries</creatorcontrib><creatorcontrib>Lipman, Jeffrey</creatorcontrib><creatorcontrib>Scribante, Juan</creatorcontrib><creatorcontrib>Tshukutsoane, Shephelia</creatorcontrib><creatorcontrib>Hon, Hubert</creatorcontrib><creatorcontrib>Pinder, Mary</creatorcontrib><creatorcontrib>Mathivha, Rudo</creatorcontrib><creatorcontrib>Verhoef, Lia</creatorcontrib><creatorcontrib>Stass, Heino</creatorcontrib><title>Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>This study aimed to investigate whether fluid shifts alter ciprofloxacin pharmacokinetics in critically ill patients over time. Patients ≥18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with documented intra-abdominal infections. Group B (18 patients) included patients with severe sepsis from other causes. All patients received intravenous ciprofloxacin 400
mg every 8
h infused over 60
min. Eight timed blood specimens were taken on days 0, 2 and 7. Ciprofloxacin plasma concentrations were determined using high performance liquid chromatography. There were no significant differences between the pharmacokinetics of the two groups or over time. Ciprofloxacin pharmacokinetics in critically ill patients do not change over time, and intra-abdominal sepsis does not alter ciprofloxacin pharmacokinetic parameters to a greater degree than sepsis from other causes in critically ill patients.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Bacterial Agents - pharmacokinetics</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacterial Infections - drug therapy</subject><subject>Biological and medical sciences</subject><subject>Body Fluid Compartments - physiology</subject><subject>Ciprofloxacin - pharmacokinetics</subject><subject>Ciprofloxacin - therapeutic use</subject><subject>Female</subject><subject>Fluoroquinolone</subject><subject>Humans</subject><subject>Intensive Care Unit</subject><subject>Intensive Care Units</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacokinetics</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Bacterial Infections - drug therapy</topic><topic>Biological and medical sciences</topic><topic>Body Fluid Compartments - physiology</topic><topic>Ciprofloxacin - pharmacokinetics</topic><topic>Ciprofloxacin - therapeutic use</topic><topic>Female</topic><topic>Fluoroquinolone</topic><topic>Humans</topic><topic>Intensive Care Unit</topic><topic>Intensive Care Units</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacokinetics</topic><topic>Pharmacology. 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Patients ≥18 years, with normal renal function, requiring intensive care treatment and parenteral antibiotics were enrolled. Group A (22 patients) included patients with documented intra-abdominal infections. Group B (18 patients) included patients with severe sepsis from other causes. All patients received intravenous ciprofloxacin 400
mg every 8
h infused over 60
min. Eight timed blood specimens were taken on days 0, 2 and 7. Ciprofloxacin plasma concentrations were determined using high performance liquid chromatography. There were no significant differences between the pharmacokinetics of the two groups or over time. Ciprofloxacin pharmacokinetics in critically ill patients do not change over time, and intra-abdominal sepsis does not alter ciprofloxacin pharmacokinetic parameters to a greater degree than sepsis from other causes in critically ill patients.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>15955670</pmid><doi>10.1016/j.ijantimicag.2005.04.005</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0924-8579 |
| ispartof | International journal of antimicrobial agents, 2005-07, Vol.26 (1), p.50-55 |
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| subjects | Adolescent Adult Anti-Bacterial Agents - pharmacokinetics Anti-Bacterial Agents - therapeutic use Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Bacterial Infections - drug therapy Biological and medical sciences Body Fluid Compartments - physiology Ciprofloxacin - pharmacokinetics Ciprofloxacin - therapeutic use Female Fluoroquinolone Humans Intensive Care Unit Intensive Care Units Male Medical sciences Middle Aged Pharmacokinetics Pharmacology. Drug treatments Sepsis - drug therapy Volume of distribution |
| title | Fluid shifts have no influence on ciprofloxacin pharmacokinetics in intensive care patients with intra-abdominal sepsis |
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