Bongkrekic acid ameliorates ischemic neuronal death in the cortex by preventing cytochrome c release and inhibiting astrocyte activation

Mitochondrial release of cytochrome c (cyt- c) plays a critical role in initiating cell death after cerebral ischemia. The objective of this study was to determine whether bongkrekic acid (BKA) ameliorates ischemic neuronal damage by inhibiting the release of cyt- c. These results showed that a 10 m...

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Veröffentlicht in:	Neuroscience letters 2005-08, Vol.384 (3), p.277-281
Hauptverfasser:	Muranyi, Marianna, Li, Ping-An
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Astrocyte Astrocytes - drug effects Astrocytes - pathology Biological and medical sciences Bongkrekic acid Bongkrekic Acid - administration & dosage Brain Ischemia - enzymology Brain Ischemia - pathology Brain Ischemia - prevention & control Cerebral ischemia Cytochrome c Cytochromes c - metabolism Fundamental and applied biological sciences. Psychology Male Medical sciences MPT Neurology Neuronal death Neurons - drug effects Neurons - enzymology Neurons - pathology Neuroprotective Agents - administration & dosage Rats Rats, Wistar Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs
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