Bongkrekic acid ameliorates ischemic neuronal death in the cortex by preventing cytochrome c release and inhibiting astrocyte activation
Mitochondrial release of cytochrome c (cyt- c) plays a critical role in initiating cell death after cerebral ischemia. The objective of this study was to determine whether bongkrekic acid (BKA) ameliorates ischemic neuronal damage by inhibiting the release of cyt- c. These results showed that a 10 m...
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| Veröffentlicht in: | Neuroscience letters 2005-08, Vol.384 (3), p.277-281 |
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| container_title | Neuroscience letters |
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| creator | Muranyi, Marianna Li, Ping-An |
| description | Mitochondrial release of cytochrome
c (cyt-
c) plays a critical role in initiating cell death after cerebral ischemia. The objective of this study was to determine whether bongkrekic acid (BKA) ameliorates ischemic neuronal damage by inhibiting the release of cyt-
c. These results showed that a 10
min period of global ischemia caused neuronal death, increased the release of cyt-
c and activated astrocytes in the cortex and CA1. BKA treatment reduced ischemic-induced neuronal death, prevented cyt-
c release and inhibited astrocyte activation in the cortex, but not in the CA1. These results suggest that the neuroprotective effect of BKA is associated with its ability to prevent cyt-
c release and to inhibit astrocyte activation. |
| doi_str_mv | 10.1016/j.neulet.2005.05.011 |
| format | Article |
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c (cyt-
c) plays a critical role in initiating cell death after cerebral ischemia. The objective of this study was to determine whether bongkrekic acid (BKA) ameliorates ischemic neuronal damage by inhibiting the release of cyt-
c. These results showed that a 10
min period of global ischemia caused neuronal death, increased the release of cyt-
c and activated astrocytes in the cortex and CA1. BKA treatment reduced ischemic-induced neuronal death, prevented cyt-
c release and inhibited astrocyte activation in the cortex, but not in the CA1. These results suggest that the neuroprotective effect of BKA is associated with its ability to prevent cyt-
c release and to inhibit astrocyte activation.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2005.05.011</identifier><identifier>PMID: 15919152</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Apoptosis - drug effects ; Astrocyte ; Astrocytes - drug effects ; Astrocytes - pathology ; Biological and medical sciences ; Bongkrekic acid ; Bongkrekic Acid - administration & dosage ; Brain Ischemia - enzymology ; Brain Ischemia - pathology ; Brain Ischemia - prevention & control ; Cerebral ischemia ; Cytochrome c ; Cytochromes c - metabolism ; Fundamental and applied biological sciences. Psychology ; Male ; Medical sciences ; MPT ; Neurology ; Neuronal death ; Neurons - drug effects ; Neurons - enzymology ; Neurons - pathology ; Neuroprotective Agents - administration & dosage ; Rats ; Rats, Wistar ; Vascular diseases and vascular malformations of the nervous system ; Vertebrates: nervous system and sense organs</subject><ispartof>Neuroscience letters, 2005-08, Vol.384 (3), p.277-281</ispartof><rights>2005 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-9ef1f95c7c3fcaa7609d8f5d25bc84df975e02c882e18cd423618f71706fa0e13</citedby><cites>FETCH-LOGICAL-c456t-9ef1f95c7c3fcaa7609d8f5d25bc84df975e02c882e18cd423618f71706fa0e13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304394005005173$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16915500$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15919152$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Muranyi, Marianna</creatorcontrib><creatorcontrib>Li, Ping-An</creatorcontrib><title>Bongkrekic acid ameliorates ischemic neuronal death in the cortex by preventing cytochrome c release and inhibiting astrocyte activation</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>Mitochondrial release of cytochrome
c (cyt-
c) plays a critical role in initiating cell death after cerebral ischemia. The objective of this study was to determine whether bongkrekic acid (BKA) ameliorates ischemic neuronal damage by inhibiting the release of cyt-
c. These results showed that a 10
min period of global ischemia caused neuronal death, increased the release of cyt-
c and activated astrocytes in the cortex and CA1. BKA treatment reduced ischemic-induced neuronal death, prevented cyt-
c release and inhibited astrocyte activation in the cortex, but not in the CA1. These results suggest that the neuroprotective effect of BKA is associated with its ability to prevent cyt-
c release and to inhibit astrocyte activation.</description><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Astrocyte</subject><subject>Astrocytes - drug effects</subject><subject>Astrocytes - pathology</subject><subject>Biological and medical sciences</subject><subject>Bongkrekic acid</subject><subject>Bongkrekic Acid - administration & dosage</subject><subject>Brain Ischemia - enzymology</subject><subject>Brain Ischemia - pathology</subject><subject>Brain Ischemia - prevention & control</subject><subject>Cerebral ischemia</subject><subject>Cytochrome c</subject><subject>Cytochromes c - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>MPT</subject><subject>Neurology</subject><subject>Neuronal death</subject><subject>Neurons - drug effects</subject><subject>Neurons - enzymology</subject><subject>Neurons - pathology</subject><subject>Neuroprotective Agents - administration & dosage</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kcuOEzEQRS0EYsLAHyDkDew6uLrb_dggMSNe0khsYG055fLEmW472E5E_oDPxk0izQ6pJC_uqVvluoy9BrEGAd373drTYaK8roWQ66UAnrAVDH1d9WNfP2Ur0Yi2asZWXLEXKe1EAUG2z9kVyBFGkPWK_bkJ_v4h0oNDrtEZrmeaXIg6U-Iu4ZbmopRJMXg9cUM6b7nzPG-JY4iZfvPNie8jHcln5-85nnLAbQxz0XmkiXQirr0pTVu3cf8YnXIMBSwCZnfU2QX_kj2zekr06vJes5-fP_24_Vrdff_y7fbjXYWt7HI1kgU7Suyxsah134nRDFaaWm5waI0de0mixmGoCQY0bd10MNgeetFZLQiaa_bu7LuP4deBUlZz-SZNk_YUDkl15XZtA6KA7RnEGFKKZNU-ulnHkwKhlgTUTp0TUEsCailY_N9c_A-bmcxj0-XkBXh7AXRCPdmoPbr0yHWFkmKZ_-HMUbnG0VFUCR15JOMiYVYmuP9v8hcs16nE</recordid><startdate>20050826</startdate><enddate>20050826</enddate><creator>Muranyi, Marianna</creator><creator>Li, Ping-An</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20050826</creationdate><title>Bongkrekic acid ameliorates ischemic neuronal death in the cortex by preventing cytochrome c release and inhibiting astrocyte activation</title><author>Muranyi, Marianna ; Li, Ping-An</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-9ef1f95c7c3fcaa7609d8f5d25bc84df975e02c882e18cd423618f71706fa0e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Astrocyte</topic><topic>Astrocytes - drug effects</topic><topic>Astrocytes - pathology</topic><topic>Biological and medical sciences</topic><topic>Bongkrekic acid</topic><topic>Bongkrekic Acid - administration & dosage</topic><topic>Brain Ischemia - enzymology</topic><topic>Brain Ischemia - pathology</topic><topic>Brain Ischemia - prevention & control</topic><topic>Cerebral ischemia</topic><topic>Cytochrome c</topic><topic>Cytochromes c - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>MPT</topic><topic>Neurology</topic><topic>Neuronal death</topic><topic>Neurons - drug effects</topic><topic>Neurons - enzymology</topic><topic>Neurons - pathology</topic><topic>Neuroprotective Agents - administration & dosage</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muranyi, Marianna</creatorcontrib><creatorcontrib>Li, Ping-An</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muranyi, Marianna</au><au>Li, Ping-An</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bongkrekic acid ameliorates ischemic neuronal death in the cortex by preventing cytochrome c release and inhibiting astrocyte activation</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2005-08-26</date><risdate>2005</risdate><volume>384</volume><issue>3</issue><spage>277</spage><epage>281</epage><pages>277-281</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Mitochondrial release of cytochrome
c (cyt-
c) plays a critical role in initiating cell death after cerebral ischemia. The objective of this study was to determine whether bongkrekic acid (BKA) ameliorates ischemic neuronal damage by inhibiting the release of cyt-
c. These results showed that a 10
min period of global ischemia caused neuronal death, increased the release of cyt-
c and activated astrocytes in the cortex and CA1. BKA treatment reduced ischemic-induced neuronal death, prevented cyt-
c release and inhibited astrocyte activation in the cortex, but not in the CA1. These results suggest that the neuroprotective effect of BKA is associated with its ability to prevent cyt-
c release and to inhibit astrocyte activation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>15919152</pmid><doi>10.1016/j.neulet.2005.05.011</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neuroscience letters, 2005-08, Vol.384 (3), p.277-281 |
| issn | 0304-3940 1872-7972 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Apoptosis - drug effects Astrocyte Astrocytes - drug effects Astrocytes - pathology Biological and medical sciences Bongkrekic acid Bongkrekic Acid - administration & dosage Brain Ischemia - enzymology Brain Ischemia - pathology Brain Ischemia - prevention & control Cerebral ischemia Cytochrome c Cytochromes c - metabolism Fundamental and applied biological sciences. Psychology Male Medical sciences MPT Neurology Neuronal death Neurons - drug effects Neurons - enzymology Neurons - pathology Neuroprotective Agents - administration & dosage Rats Rats, Wistar Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs |
| title | Bongkrekic acid ameliorates ischemic neuronal death in the cortex by preventing cytochrome c release and inhibiting astrocyte activation |
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