Voxel-wise analysis of [123I]β-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease
To investigate the cerebral dopamine transporter status in the early stages of the parkinson-variant of multiple system atrophy (MSA-P), 15 patients with MSA-P and a disease duration up to 3 years were studied with [123I]β-CIT single photon emission computed tomography (SPECT). Data were compared wi...
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| creator | Scherfler, Christoph Seppi, Klaus Donnemiller, Eveline Goebel, Georg Brenneis, Christian Virgolini, Irene Wenning, Gregor K. Poewe, Werner |
| description | To investigate the cerebral dopamine transporter status in the early stages of the parkinson-variant of multiple system atrophy (MSA-P), 15 patients with MSA-P and a disease duration up to 3 years were studied with [123I]β-CIT single photon emission computed tomography (SPECT). Data were compared with 13 age-matched healthy control subjects and 15 patients with idiopathic Parkinson's disease (IPD), matched for age and disease duration. Parametric SPECT images of the specific-to-nondisplaceable equilibrium partition coefficient (V3″), which is proportional to the receptor density (Bmax) have been generated. To objectively localize focal changes in dopaminergic function throughout the entire brain volume without having to make an a priori hypothesis as to their location, statistical parametric mapping (SPM) was applied to our [123I]β-CIT SPECT study. Both MSA-P and IPD patients showed significant decreases in striatal [123I]β-CIT SPECT uptake. However, in MSA-P patients an additional reduction in midbrain [123I]β-CIT signal was localized with SPM compared with control subjects (MSA-P, V3″: 0.89 ± 0.37 versus controls V3″: 1.81 ± 0.38; P < 0.001) and patients with IPD (V3″: 1.84 ± 0.26; P < 0.001). Stepwise linear discriminant analysis of mean [123I]β-CIT uptake in the putamen, caudate and midbrain identified the caudate and midbrain as indices to classify correctly 95.2% of subjects as either normal, patients with MSA-P or IPD. Voxel-wise analysis of [123I]β-CIT SPECT revealed more widespread decline of monoaminergic transporter availability in MSA-P compared with IPD, matching the underlying pathological features. We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]β-CIT SPECT in patients with uncertain parkinsonism. |
| doi_str_mv | 10.1093/brain/awh485 |
| format | Article |
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Data were compared with 13 age-matched healthy control subjects and 15 patients with idiopathic Parkinson's disease (IPD), matched for age and disease duration. Parametric SPECT images of the specific-to-nondisplaceable equilibrium partition coefficient (V3″), which is proportional to the receptor density (Bmax) have been generated. To objectively localize focal changes in dopaminergic function throughout the entire brain volume without having to make an a priori hypothesis as to their location, statistical parametric mapping (SPM) was applied to our [123I]β-CIT SPECT study. Both MSA-P and IPD patients showed significant decreases in striatal [123I]β-CIT SPECT uptake. However, in MSA-P patients an additional reduction in midbrain [123I]β-CIT signal was localized with SPM compared with control subjects (MSA-P, V3″: 0.89 ± 0.37 versus controls V3″: 1.81 ± 0.38; P < 0.001) and patients with IPD (V3″: 1.84 ± 0.26; P < 0.001). Stepwise linear discriminant analysis of mean [123I]β-CIT uptake in the putamen, caudate and midbrain identified the caudate and midbrain as indices to classify correctly 95.2% of subjects as either normal, patients with MSA-P or IPD. Voxel-wise analysis of [123I]β-CIT SPECT revealed more widespread decline of monoaminergic transporter availability in MSA-P compared with IPD, matching the underlying pathological features. We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]β-CIT SPECT in patients with uncertain parkinsonism.</description><identifier>ISSN: 0006-8950</identifier><identifier>EISSN: 1460-2156</identifier><identifier>DOI: 10.1093/brain/awh485</identifier><identifier>PMID: 15817519</identifier><identifier>CODEN: BRAIAK</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>[123I]β-CIT = [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane ; [123I]β-CIT SPECT ; Aged ; AI = asymmetry index ; Biological and medical sciences ; Case-Control Studies ; Caudate Nucleus - metabolism ; CI = confidence interval ; Cocaine - analogs & derivatives ; Corpus Striatum - metabolism ; DAT = dopamine transporter ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Diagnosis, Differential ; Discriminant Analysis ; Dopamine - metabolism ; Dopamine Plasma Membrane Transport Proteins ; FDG = fluorodesoxyglucose ; Female ; FWHM = full width at half maximum ; H&Y = Hoehn and Yahr ; Humans ; idiopathic Parkinson's disease ; IPD = idiopathic Parkinson's disease ; Linear Models ; Male ; Medical sciences ; Membrane Glycoproteins - metabolism ; Membrane Transport Proteins - metabolism ; Mesencephalon - metabolism ; Middle Aged ; MNI = Montreal Neurological Institute ; MSA-P = parkinsonian-variant of MSA ; Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis ; multiple system atrophy ; Multiple System Atrophy - diagnostic imaging ; Multiple System Atrophy - metabolism ; NAT = noradrenergic transporter ; Nerve Tissue Proteins - metabolism ; Neurology ; Parkinson Disease - diagnostic imaging ; Parkinson Disease - metabolism ; PET = positron emission tomography ; Radiopharmaceuticals ; Receptors, Dopamine D2 - metabolism ; ROI = region of interest ; SERT = serotonin transporter ; SPECT = single photon emission computed tomography ; SPM = statistical parametric mapping ; statistical parametric mapping ; Tomography, Emission-Computed, Single-Photon ; UPDRS = Unified Parkinson's Disease Rating Scale ; V3″ = specific-to-nondisplaceable equilibrium partition coefficient</subject><ispartof>Brain (London, England : 1878), 2005-07, Vol.128 (7), p.1605-1612</ispartof><rights>2005 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Jul 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-6b2c4322a0428191cb43be66d0abdd4534ea7867ec79df9a03872e888c5f5f753</citedby><cites>FETCH-LOGICAL-c415t-6b2c4322a0428191cb43be66d0abdd4534ea7867ec79df9a03872e888c5f5f753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16941208$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15817519$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scherfler, Christoph</creatorcontrib><creatorcontrib>Seppi, Klaus</creatorcontrib><creatorcontrib>Donnemiller, Eveline</creatorcontrib><creatorcontrib>Goebel, Georg</creatorcontrib><creatorcontrib>Brenneis, Christian</creatorcontrib><creatorcontrib>Virgolini, Irene</creatorcontrib><creatorcontrib>Wenning, Gregor K.</creatorcontrib><creatorcontrib>Poewe, Werner</creatorcontrib><title>Voxel-wise analysis of [123I]β-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease</title><title>Brain (London, England : 1878)</title><addtitle>Brain</addtitle><description>To investigate the cerebral dopamine transporter status in the early stages of the parkinson-variant of multiple system atrophy (MSA-P), 15 patients with MSA-P and a disease duration up to 3 years were studied with [123I]β-CIT single photon emission computed tomography (SPECT). Data were compared with 13 age-matched healthy control subjects and 15 patients with idiopathic Parkinson's disease (IPD), matched for age and disease duration. Parametric SPECT images of the specific-to-nondisplaceable equilibrium partition coefficient (V3″), which is proportional to the receptor density (Bmax) have been generated. To objectively localize focal changes in dopaminergic function throughout the entire brain volume without having to make an a priori hypothesis as to their location, statistical parametric mapping (SPM) was applied to our [123I]β-CIT SPECT study. Both MSA-P and IPD patients showed significant decreases in striatal [123I]β-CIT SPECT uptake. However, in MSA-P patients an additional reduction in midbrain [123I]β-CIT signal was localized with SPM compared with control subjects (MSA-P, V3″: 0.89 ± 0.37 versus controls V3″: 1.81 ± 0.38; P < 0.001) and patients with IPD (V3″: 1.84 ± 0.26; P < 0.001). Stepwise linear discriminant analysis of mean [123I]β-CIT uptake in the putamen, caudate and midbrain identified the caudate and midbrain as indices to classify correctly 95.2% of subjects as either normal, patients with MSA-P or IPD. Voxel-wise analysis of [123I]β-CIT SPECT revealed more widespread decline of monoaminergic transporter availability in MSA-P compared with IPD, matching the underlying pathological features. We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]β-CIT SPECT in patients with uncertain parkinsonism.</description><subject>[123I]β-CIT = [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane</subject><subject>[123I]β-CIT SPECT</subject><subject>Aged</subject><subject>AI = asymmetry index</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Caudate Nucleus - metabolism</subject><subject>CI = confidence interval</subject><subject>Cocaine - analogs & derivatives</subject><subject>Corpus Striatum - metabolism</subject><subject>DAT = dopamine transporter</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Diagnosis, Differential</subject><subject>Discriminant Analysis</subject><subject>Dopamine - metabolism</subject><subject>Dopamine Plasma Membrane Transport Proteins</subject><subject>FDG = fluorodesoxyglucose</subject><subject>Female</subject><subject>FWHM = full width at half maximum</subject><subject>H&Y = Hoehn and Yahr</subject><subject>Humans</subject><subject>idiopathic Parkinson's disease</subject><subject>IPD = idiopathic Parkinson's disease</subject><subject>Linear Models</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Glycoproteins - metabolism</subject><subject>Membrane Transport Proteins - metabolism</subject><subject>Mesencephalon - metabolism</subject><subject>Middle Aged</subject><subject>MNI = Montreal Neurological Institute</subject><subject>MSA-P = parkinsonian-variant of MSA</subject><subject>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</subject><subject>multiple system atrophy</subject><subject>Multiple System Atrophy - diagnostic imaging</subject><subject>Multiple System Atrophy - metabolism</subject><subject>NAT = noradrenergic transporter</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Neurology</subject><subject>Parkinson Disease - diagnostic imaging</subject><subject>Parkinson Disease - metabolism</subject><subject>PET = positron emission tomography</subject><subject>Radiopharmaceuticals</subject><subject>Receptors, Dopamine D2 - metabolism</subject><subject>ROI = region of interest</subject><subject>SERT = serotonin transporter</subject><subject>SPECT = single photon emission computed tomography</subject><subject>SPM = statistical parametric mapping</subject><subject>statistical parametric mapping</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><subject>UPDRS = Unified Parkinson's Disease Rating Scale</subject><subject>V3″ = specific-to-nondisplaceable equilibrium partition coefficient</subject><issn>0006-8950</issn><issn>1460-2156</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0d-K1DAUBvAiijuu3nktQVBvrJuk-Xu5DOvOLCsuOIooUk7TlMnaNjVp3Z2H8GV8EJ_JjDM44I1XucjvfHDOl2WPCX5FsC5OqgCuP4GbNVP8TjYjTOCcEi7uZjOMsciV5vgoexDjNcaEFVTcz44IV0RyomfZjw_-1rb5jYsWQQ_tJrqIfIM-E1osv_z6mc-XK_Tu6my-QrVrGhtsPzoYbUTj2qIrCF9dH32PvkNw0I_b0W5qRze0FsVNHG2HYAx-WG9QE3yHXO38AOPamcPwi5iyo4VoH2b3GmijfbR_j7P3r89W80V--fZ8OT-9zA0jfMxFRU3ahAJmVBFNTMWKygpRY6jqmvGCWZBKSGukrhsNuFCSWqWU4Q1vJC-Os-e73CH4b5ONY9m5aGzbQm_9FEshtWSUqv9CooWWSskEn_4Dr_0U0kG3hjOq0_ETerlDJvgYg23KIbgOwqYkuNyWWf4ps9yVmfiTfeZUdbY-4H17CTzbA4gG2iZAb1w8OKEZoXi7Rb5zLhVy-_c_3T9tWkheLj5-KqV6c35xwRelLH4DvJO5kg</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Scherfler, Christoph</creator><creator>Seppi, Klaus</creator><creator>Donnemiller, Eveline</creator><creator>Goebel, Georg</creator><creator>Brenneis, Christian</creator><creator>Virgolini, Irene</creator><creator>Wenning, Gregor K.</creator><creator>Poewe, Werner</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Voxel-wise analysis of [123I]β-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease</title><author>Scherfler, Christoph ; Seppi, Klaus ; Donnemiller, Eveline ; Goebel, Georg ; Brenneis, Christian ; Virgolini, Irene ; Wenning, Gregor K. ; Poewe, Werner</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-6b2c4322a0428191cb43be66d0abdd4534ea7867ec79df9a03872e888c5f5f753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>[123I]β-CIT = [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane</topic><topic>[123I]β-CIT SPECT</topic><topic>Aged</topic><topic>AI = asymmetry index</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Caudate Nucleus - metabolism</topic><topic>CI = confidence interval</topic><topic>Cocaine - analogs & derivatives</topic><topic>Corpus Striatum - metabolism</topic><topic>DAT = dopamine transporter</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Diagnosis, Differential</topic><topic>Discriminant Analysis</topic><topic>Dopamine - metabolism</topic><topic>Dopamine Plasma Membrane Transport Proteins</topic><topic>FDG = fluorodesoxyglucose</topic><topic>Female</topic><topic>FWHM = full width at half maximum</topic><topic>H&Y = Hoehn and Yahr</topic><topic>Humans</topic><topic>idiopathic Parkinson's disease</topic><topic>IPD = idiopathic Parkinson's disease</topic><topic>Linear Models</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Glycoproteins - metabolism</topic><topic>Membrane Transport Proteins - metabolism</topic><topic>Mesencephalon - metabolism</topic><topic>Middle Aged</topic><topic>MNI = Montreal Neurological Institute</topic><topic>MSA-P = parkinsonian-variant of MSA</topic><topic>Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis</topic><topic>multiple system atrophy</topic><topic>Multiple System Atrophy - diagnostic imaging</topic><topic>Multiple System Atrophy - metabolism</topic><topic>NAT = noradrenergic transporter</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Neurology</topic><topic>Parkinson Disease - diagnostic imaging</topic><topic>Parkinson Disease - metabolism</topic><topic>PET = positron emission tomography</topic><topic>Radiopharmaceuticals</topic><topic>Receptors, Dopamine D2 - metabolism</topic><topic>ROI = region of interest</topic><topic>SERT = serotonin transporter</topic><topic>SPECT = single photon emission computed tomography</topic><topic>SPM = statistical parametric mapping</topic><topic>statistical parametric mapping</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><topic>UPDRS = Unified Parkinson's Disease Rating Scale</topic><topic>V3″ = specific-to-nondisplaceable equilibrium partition coefficient</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scherfler, Christoph</creatorcontrib><creatorcontrib>Seppi, Klaus</creatorcontrib><creatorcontrib>Donnemiller, Eveline</creatorcontrib><creatorcontrib>Goebel, Georg</creatorcontrib><creatorcontrib>Brenneis, Christian</creatorcontrib><creatorcontrib>Virgolini, Irene</creatorcontrib><creatorcontrib>Wenning, Gregor K.</creatorcontrib><creatorcontrib>Poewe, Werner</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain (London, England : 1878)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scherfler, Christoph</au><au>Seppi, Klaus</au><au>Donnemiller, Eveline</au><au>Goebel, Georg</au><au>Brenneis, Christian</au><au>Virgolini, Irene</au><au>Wenning, Gregor K.</au><au>Poewe, Werner</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Voxel-wise analysis of [123I]β-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease</atitle><jtitle>Brain (London, England : 1878)</jtitle><addtitle>Brain</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>128</volume><issue>7</issue><spage>1605</spage><epage>1612</epage><pages>1605-1612</pages><issn>0006-8950</issn><eissn>1460-2156</eissn><coden>BRAIAK</coden><abstract>To investigate the cerebral dopamine transporter status in the early stages of the parkinson-variant of multiple system atrophy (MSA-P), 15 patients with MSA-P and a disease duration up to 3 years were studied with [123I]β-CIT single photon emission computed tomography (SPECT). Data were compared with 13 age-matched healthy control subjects and 15 patients with idiopathic Parkinson's disease (IPD), matched for age and disease duration. Parametric SPECT images of the specific-to-nondisplaceable equilibrium partition coefficient (V3″), which is proportional to the receptor density (Bmax) have been generated. To objectively localize focal changes in dopaminergic function throughout the entire brain volume without having to make an a priori hypothesis as to their location, statistical parametric mapping (SPM) was applied to our [123I]β-CIT SPECT study. Both MSA-P and IPD patients showed significant decreases in striatal [123I]β-CIT SPECT uptake. However, in MSA-P patients an additional reduction in midbrain [123I]β-CIT signal was localized with SPM compared with control subjects (MSA-P, V3″: 0.89 ± 0.37 versus controls V3″: 1.81 ± 0.38; P < 0.001) and patients with IPD (V3″: 1.84 ± 0.26; P < 0.001). Stepwise linear discriminant analysis of mean [123I]β-CIT uptake in the putamen, caudate and midbrain identified the caudate and midbrain as indices to classify correctly 95.2% of subjects as either normal, patients with MSA-P or IPD. Voxel-wise analysis of [123I]β-CIT SPECT revealed more widespread decline of monoaminergic transporter availability in MSA-P compared with IPD, matching the underlying pathological features. We suggest that the quantification of midbrain DAT signal should be included in the routine clinical analysis of [123I]β-CIT SPECT in patients with uncertain parkinsonism.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>15817519</pmid><doi>10.1093/brain/awh485</doi><tpages>8</tpages></addata></record> |
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| ispartof | Brain (London, England : 1878), 2005-07, Vol.128 (7), p.1605-1612 |
| issn | 0006-8950 1460-2156 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | [123I]β-CIT = [123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane [123I]β-CIT SPECT Aged AI = asymmetry index Biological and medical sciences Case-Control Studies Caudate Nucleus - metabolism CI = confidence interval Cocaine - analogs & derivatives Corpus Striatum - metabolism DAT = dopamine transporter Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diagnosis, Differential Discriminant Analysis Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins FDG = fluorodesoxyglucose Female FWHM = full width at half maximum H&Y = Hoehn and Yahr Humans idiopathic Parkinson's disease IPD = idiopathic Parkinson's disease Linear Models Male Medical sciences Membrane Glycoproteins - metabolism Membrane Transport Proteins - metabolism Mesencephalon - metabolism Middle Aged MNI = Montreal Neurological Institute MSA-P = parkinsonian-variant of MSA Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis multiple system atrophy Multiple System Atrophy - diagnostic imaging Multiple System Atrophy - metabolism NAT = noradrenergic transporter Nerve Tissue Proteins - metabolism Neurology Parkinson Disease - diagnostic imaging Parkinson Disease - metabolism PET = positron emission tomography Radiopharmaceuticals Receptors, Dopamine D2 - metabolism ROI = region of interest SERT = serotonin transporter SPECT = single photon emission computed tomography SPM = statistical parametric mapping statistical parametric mapping Tomography, Emission-Computed, Single-Photon UPDRS = Unified Parkinson's Disease Rating Scale V3″ = specific-to-nondisplaceable equilibrium partition coefficient |
| title | Voxel-wise analysis of [123I]β-CIT SPECT differentiates the Parkinson variant of multiple system atrophy from idiopathic Parkinson's disease |
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