Genetic Diversity of Human Metapneumovirus over 4 Consecutive Years in Australia
The molecular epidemiologic profile of human metapneumovirus (hMPV) infection has likely been skewed toward certain genetic subtypes because of assay-design issues, and no comprehensive studies have been conducted to date. Here, reverse-transcription polymerase chain reaction was used to screen 10,3...
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| Veröffentlicht in: | The Journal of infectious diseases 2006-06, Vol.193 (12), p.1630-1633 |
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| container_title | The Journal of infectious diseases |
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| creator | Mackay, Ian M. Bialasiewicz, Seweryn Jacob, Kevin C. McQueen, Emily Arden, Katherine E. Nissen, Michael D. Sloots, Theo P. |
| description | The molecular epidemiologic profile of human metapneumovirus (hMPV) infection has likely been skewed toward certain genetic subtypes because of assay-design issues, and no comprehensive studies have been conducted to date. Here, reverse-transcription polymerase chain reaction was used to screen 10,319 specimens from patients presenting to hospitals with suspected respiratory tract infections during 2001–2004. After analysis of 727 Australian hMPV strains, 640 were assigned to 1 of 4 previously described subtypes. hMPV was the most common pathogen detected, and subtype B1 was the most common lineage. Concurrent, annual circulation of all 4 hMPV subtypes in our study population was common, with a single, usually different hMPV subtype predominating in each year |
| doi_str_mv | 10.1086/504260 |
| format | Article |
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Here, reverse-transcription polymerase chain reaction was used to screen 10,319 specimens from patients presenting to hospitals with suspected respiratory tract infections during 2001–2004. After analysis of 727 Australian hMPV strains, 640 were assigned to 1 of 4 previously described subtypes. hMPV was the most common pathogen detected, and subtype B1 was the most common lineage. 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Psychology ; Genes, Viral ; Genetic Variation ; Genotype ; Human genetics ; Human metapneumovirus ; Humans ; Infant ; Infant, Newborn ; Infections ; Infectious diseases ; Male ; Medical genetics ; Medical sciences ; Metapneumovirus ; Metapneumovirus - classification ; Metapneumovirus - genetics ; Metapneumovirus - isolation & purification ; Microbiology ; Middle Aged ; Molecular Epidemiology ; Molecular Sequence Data ; Paramyxoviridae Infections - epidemiology ; Paramyxoviridae Infections - virology ; Pediatrics ; Phylogeny ; Polymerase chain reaction ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - virology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Viral - genetics ; Seasons ; Sequence Analysis, DNA ; Specimens ; Viruses</subject><ispartof>The Journal of infectious diseases, 2006-06, Vol.193 (12), p.1630-1633</ispartof><rights>Copyright 2006 Infectious Diseases Society of America</rights><rights>2006 by the Infectious Diseases Society of America 2006</rights><rights>2006 INIST-CNRS</rights><rights>Copyright University of Chicago Press Jun 15, 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-13ad12cac5686b143c7f6eed32a70a764a9b73afd311e14e1a82fff3e7621bee3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30086582$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30086582$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17834544$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16703505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mackay, Ian M.</creatorcontrib><creatorcontrib>Bialasiewicz, Seweryn</creatorcontrib><creatorcontrib>Jacob, Kevin C.</creatorcontrib><creatorcontrib>McQueen, Emily</creatorcontrib><creatorcontrib>Arden, Katherine E.</creatorcontrib><creatorcontrib>Nissen, Michael D.</creatorcontrib><creatorcontrib>Sloots, Theo P.</creatorcontrib><title>Genetic Diversity of Human Metapneumovirus over 4 Consecutive Years in Australia</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>J Infect Dis</addtitle><description>The molecular epidemiologic profile of human metapneumovirus (hMPV) infection has likely been skewed toward certain genetic subtypes because of assay-design issues, and no comprehensive studies have been conducted to date. Here, reverse-transcription polymerase chain reaction was used to screen 10,319 specimens from patients presenting to hospitals with suspected respiratory tract infections during 2001–2004. After analysis of 727 Australian hMPV strains, 640 were assigned to 1 of 4 previously described subtypes. hMPV was the most common pathogen detected, and subtype B1 was the most common lineage. Concurrent, annual circulation of all 4 hMPV subtypes in our study population was common, with a single, usually different hMPV subtype predominating in each year</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Australia - epidemiology</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child health services</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, Viral</subject><subject>Genetic Variation</subject><subject>Genotype</subject><subject>Human genetics</subject><subject>Human metapneumovirus</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Metapneumovirus</subject><subject>Metapneumovirus - classification</subject><subject>Metapneumovirus - genetics</subject><subject>Metapneumovirus - isolation & purification</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Molecular Sequence Data</subject><subject>Paramyxoviridae Infections - epidemiology</subject><subject>Paramyxoviridae Infections - virology</subject><subject>Pediatrics</subject><subject>Phylogeny</subject><subject>Polymerase chain reaction</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - virology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Viral - genetics</subject><subject>Seasons</subject><subject>Sequence Analysis, DNA</subject><subject>Specimens</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1v1DAQBmALgei2hX8AMkhwC_grdnIsW9qtVApIUD4u1qx3InmbxIsdV_Tfk1VWbYWEOPkwj8eedwh5ytkbzir9tmRKaPaAzHgpTaE1lw_JjDEhCl7V9R7ZT2nNGFNSm8dkj2vDZMnKGfl0ij0O3tFjf40x-eGGhoYucgc9_YADbHrMXbj2MScaRkEVnYc-ocvDeIH-QIiJ-p4e5TREaD0ckkcNtAmf7M4D8vXk_Zf5ojj_eHo2PzovXKnqoeASVlw4cKWu9JIr6UyjEVdSgGFgtIJ6aSQ0K8k5coUcKtE0jUSjBV8iygPyeuq7ieFXxjTYzieHbQs9hpysNrWRFav_C3ktheGVGuHLv-A65NiPQ1ghZL0N8143F0NKERu7ib6DeGM5s9tN2GkTI3y-65aXHa7u2C76EbzaAUgO2iZC73y6c6aSqlTbb72YXMibfz_2bDLrNIR4qyQbTVmJsV5MdZ8G_H1bh3g15iRNaRfff9qTy3eLb-zys72QfwBtKbF6</recordid><startdate>20060615</startdate><enddate>20060615</enddate><creator>Mackay, Ian M.</creator><creator>Bialasiewicz, Seweryn</creator><creator>Jacob, Kevin C.</creator><creator>McQueen, Emily</creator><creator>Arden, Katherine E.</creator><creator>Nissen, Michael D.</creator><creator>Sloots, Theo P.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20060615</creationdate><title>Genetic Diversity of Human Metapneumovirus over 4 Consecutive Years in Australia</title><author>Mackay, Ian M. ; Bialasiewicz, Seweryn ; Jacob, Kevin C. ; McQueen, Emily ; Arden, Katherine E. ; Nissen, Michael D. ; Sloots, Theo P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-13ad12cac5686b143c7f6eed32a70a764a9b73afd311e14e1a82fff3e7621bee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Australia - epidemiology</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child health services</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, Viral</topic><topic>Genetic Variation</topic><topic>Genotype</topic><topic>Human genetics</topic><topic>Human metapneumovirus</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Metapneumovirus</topic><topic>Metapneumovirus - classification</topic><topic>Metapneumovirus - genetics</topic><topic>Metapneumovirus - isolation & purification</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Molecular Sequence Data</topic><topic>Paramyxoviridae Infections - epidemiology</topic><topic>Paramyxoviridae Infections - virology</topic><topic>Pediatrics</topic><topic>Phylogeny</topic><topic>Polymerase chain reaction</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - virology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Viral - genetics</topic><topic>Seasons</topic><topic>Sequence Analysis, DNA</topic><topic>Specimens</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mackay, Ian M.</creatorcontrib><creatorcontrib>Bialasiewicz, Seweryn</creatorcontrib><creatorcontrib>Jacob, Kevin C.</creatorcontrib><creatorcontrib>McQueen, Emily</creatorcontrib><creatorcontrib>Arden, Katherine E.</creatorcontrib><creatorcontrib>Nissen, Michael D.</creatorcontrib><creatorcontrib>Sloots, Theo P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mackay, Ian M.</au><au>Bialasiewicz, Seweryn</au><au>Jacob, Kevin C.</au><au>McQueen, Emily</au><au>Arden, Katherine E.</au><au>Nissen, Michael D.</au><au>Sloots, Theo P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Diversity of Human Metapneumovirus over 4 Consecutive Years in Australia</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>J Infect Dis</addtitle><date>2006-06-15</date><risdate>2006</risdate><volume>193</volume><issue>12</issue><spage>1630</spage><epage>1633</epage><pages>1630-1633</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The molecular epidemiologic profile of human metapneumovirus (hMPV) infection has likely been skewed toward certain genetic subtypes because of assay-design issues, and no comprehensive studies have been conducted to date. Here, reverse-transcription polymerase chain reaction was used to screen 10,319 specimens from patients presenting to hospitals with suspected respiratory tract infections during 2001–2004. After analysis of 727 Australian hMPV strains, 640 were assigned to 1 of 4 previously described subtypes. hMPV was the most common pathogen detected, and subtype B1 was the most common lineage. Concurrent, annual circulation of all 4 hMPV subtypes in our study population was common, with a single, usually different hMPV subtype predominating in each year</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>16703505</pmid><doi>10.1086/504260</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Australia - epidemiology Biological and medical sciences Child Child health services Child, Preschool Female Fundamental and applied biological sciences. Psychology Genes, Viral Genetic Variation Genotype Human genetics Human metapneumovirus Humans Infant Infant, Newborn Infections Infectious diseases Male Medical genetics Medical sciences Metapneumovirus Metapneumovirus - classification Metapneumovirus - genetics Metapneumovirus - isolation & purification Microbiology Middle Aged Molecular Epidemiology Molecular Sequence Data Paramyxoviridae Infections - epidemiology Paramyxoviridae Infections - virology Pediatrics Phylogeny Polymerase chain reaction Respiratory Tract Infections - epidemiology Respiratory Tract Infections - virology Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - genetics Seasons Sequence Analysis, DNA Specimens Viruses |
| title | Genetic Diversity of Human Metapneumovirus over 4 Consecutive Years in Australia |
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