Peripheral Total and Differential Leukocyte Count in Diabetic Nephropathy: The relationship of plasma leptin to leukocytosis
OBJECTIVE:--Because of increasing evidence that white blood cells (WBCs) play a role in the development and progression of diabetes complications, this study aimed to investigate the relation of circulating total and differential leukocyte counts to nephropathy in patients with type 2 diabetes. Plas...
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| Veröffentlicht in: | Diabetes care 2005-07, Vol.28 (7), p.1710-1717 |
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| creator | Chung, Fu-Mei Tsai, Jack C.-R Chang, Dao-Ming Shin, Shyi-Jang Lee, Yau-Jiunn |
| description | OBJECTIVE:--Because of increasing evidence that white blood cells (WBCs) play a role in the development and progression of diabetes complications, this study aimed to investigate the relation of circulating total and differential leukocyte counts to nephropathy in patients with type 2 diabetes. Plasma leptin levels were also measured to investigate their role in peripheral leukocytosis. RESEARCH DESIGN AND METHODS--For this study, 1,480 subjects with type 2 diabetes who were enrolled in a disease management program were stratified according to urinary microalbumin and serum creatinine measurements. The total and differential leukocyte profiles of peripheral blood were measured and plasma leptin was examined by enzyme-linked immunosorbent assay. Demographic and potential metabolic confounding factors were analyzed with linear and logistic regression to calculate the effects of leukocyte count on diabetic nephropathy. RESULTS:--The peripheral total WBC, monocyte, and neutrophil counts increased in parallel with the advancement of diabetic nephropathy. In contrast, the lymphocyte count decreased. When WBC counts were analyzed per quartile and as continuous variables after adjusting for age, sex, and other known risk factors with multiple regression analysis, peripheral total WBC, monocyte, neutrophil, and lymphocyte counts were independently and significantly associated with diabetic nephropathy. Plasma leptin levels increased in patients with nephropathy and correlated significantly with total WBC count (r = 0.194, P = 0.014). CONCLUSIONS:--Because leukocytes are activated and secrete cytokines in the diabetic state and leptin stimulates leukocyte proliferation and differentiation, our results suggest that circulating leukocytes contribute to the development and progression of nephropathy, partially through the effects of leptin, in patients with type 2 diabetes. |
| doi_str_mv | 10.2337/diacare.28.7.1710 |
| format | Article |
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Plasma leptin levels were also measured to investigate their role in peripheral leukocytosis. RESEARCH DESIGN AND METHODS--For this study, 1,480 subjects with type 2 diabetes who were enrolled in a disease management program were stratified according to urinary microalbumin and serum creatinine measurements. The total and differential leukocyte profiles of peripheral blood were measured and plasma leptin was examined by enzyme-linked immunosorbent assay. Demographic and potential metabolic confounding factors were analyzed with linear and logistic regression to calculate the effects of leukocyte count on diabetic nephropathy. RESULTS:--The peripheral total WBC, monocyte, and neutrophil counts increased in parallel with the advancement of diabetic nephropathy. In contrast, the lymphocyte count decreased. When WBC counts were analyzed per quartile and as continuous variables after adjusting for age, sex, and other known risk factors with multiple regression analysis, peripheral total WBC, monocyte, neutrophil, and lymphocyte counts were independently and significantly associated with diabetic nephropathy. Plasma leptin levels increased in patients with nephropathy and correlated significantly with total WBC count (r = 0.194, P = 0.014). CONCLUSIONS:--Because leukocytes are activated and secrete cytokines in the diabetic state and leptin stimulates leukocyte proliferation and differentiation, our results suggest that circulating leukocytes contribute to the development and progression of nephropathy, partially through the effects of leptin, in patients with type 2 diabetes.</description><identifier>ISSN: 0149-5992</identifier><identifier>EISSN: 1935-5548</identifier><identifier>DOI: 10.2337/diacare.28.7.1710</identifier><identifier>PMID: 15983324</identifier><identifier>CODEN: DICAD2</identifier><language>eng</language><publisher>Alexandria, VA: American Diabetes Association</publisher><subject>Albuminuria ; Biological and medical sciences ; Biomarkers ; Blood lipids ; Case studies ; Creatinine - blood ; Cytokines ; Diabetes ; Diabetes. Impaired glucose tolerance ; Diabetic nephropathies ; Diabetic Nephropathies - blood ; Diabetic Nephropathies - urine ; Disease management ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Enzymes ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Humans ; Kidneys ; Leptin ; Leptin - blood ; Leukocyte Count ; Leukocyte disorders ; Leukocytes ; Leukocytosis - epidemiology ; Lymphocyte Count ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Regression Analysis ; Risk Factors ; Urinary system involvement in other diseases. Miscellaneous</subject><ispartof>Diabetes care, 2005-07, Vol.28 (7), p.1710-1717</ispartof><rights>2005 INIST-CNRS</rights><rights>COPYRIGHT 2005 American Diabetes Association</rights><rights>Copyright American Diabetes Association Jul 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16917953$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15983324$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chung, Fu-Mei</creatorcontrib><creatorcontrib>Tsai, Jack C.-R</creatorcontrib><creatorcontrib>Chang, Dao-Ming</creatorcontrib><creatorcontrib>Shin, Shyi-Jang</creatorcontrib><creatorcontrib>Lee, Yau-Jiunn</creatorcontrib><title>Peripheral Total and Differential Leukocyte Count in Diabetic Nephropathy: The relationship of plasma leptin to leukocytosis</title><title>Diabetes care</title><addtitle>Diabetes Care</addtitle><description>OBJECTIVE:--Because of increasing evidence that white blood cells (WBCs) play a role in the development and progression of diabetes complications, this study aimed to investigate the relation of circulating total and differential leukocyte counts to nephropathy in patients with type 2 diabetes. Plasma leptin levels were also measured to investigate their role in peripheral leukocytosis. RESEARCH DESIGN AND METHODS--For this study, 1,480 subjects with type 2 diabetes who were enrolled in a disease management program were stratified according to urinary microalbumin and serum creatinine measurements. The total and differential leukocyte profiles of peripheral blood were measured and plasma leptin was examined by enzyme-linked immunosorbent assay. Demographic and potential metabolic confounding factors were analyzed with linear and logistic regression to calculate the effects of leukocyte count on diabetic nephropathy. RESULTS:--The peripheral total WBC, monocyte, and neutrophil counts increased in parallel with the advancement of diabetic nephropathy. In contrast, the lymphocyte count decreased. When WBC counts were analyzed per quartile and as continuous variables after adjusting for age, sex, and other known risk factors with multiple regression analysis, peripheral total WBC, monocyte, neutrophil, and lymphocyte counts were independently and significantly associated with diabetic nephropathy. Plasma leptin levels increased in patients with nephropathy and correlated significantly with total WBC count (r = 0.194, P = 0.014). CONCLUSIONS:--Because leukocytes are activated and secrete cytokines in the diabetic state and leptin stimulates leukocyte proliferation and differentiation, our results suggest that circulating leukocytes contribute to the development and progression of nephropathy, partially through the effects of leptin, in patients with type 2 diabetes.</description><subject>Albuminuria</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Blood lipids</subject><subject>Case studies</subject><subject>Creatinine - blood</subject><subject>Cytokines</subject><subject>Diabetes</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Diabetic nephropathies</subject><subject>Diabetic Nephropathies - blood</subject><subject>Diabetic Nephropathies - urine</subject><subject>Disease management</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Enzymes</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Humans</subject><subject>Kidneys</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Leukocyte Count</subject><subject>Leukocyte disorders</subject><subject>Leukocytes</subject><subject>Leukocytosis - epidemiology</subject><subject>Lymphocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><issn>0149-5992</issn><issn>1935-5548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0k-LEzEUAPBBFLeufgAvOgh6m5p_k0y8LXVXhaKC3fPwmnlps06TMckcCn54s7QiyBJIwsvvvYQkVfWSkiXjXL0fHBiIuGTdUi2pouRRtaCat03biu5xtSBU6KbVml1Uz1K6I4QI0XVPqwva6o5zJhbV7-8Y3bTHCGO9Cbn04If6o7MWI_rsSmCN889gjhnrVZh9rp0v67DF7Ez9Fad9DBPk_fFDvdljHXGE7IJPezfVwdbTCOkA9YhTLnk5lNmpWkguPa-eWBgTvjiPl9XtzfVm9blZf_v0ZXW1biyXKjeDVWwrtgp02VV1nbKWMiO5lZKCUoJia42RCihng4BBorbaIrNkK0VHCL-s3p3qTjH8mjHl_uCSwXEEj2FOvVRacSXu4Zv_4F2Yoy9n6xnjRLZMi4KaE9rBiL3zNuQIZof-_hKDR-tK-IpywYjWnS5--YAvbcCDMw8mvDqfYt4ecOin6A4Qj_3fVyvg7RlAMjDaCN649M9JTZVueXGvT85C6GEXi7n9wQjlhBIiafkqfwCaQbHO</recordid><startdate>20050701</startdate><enddate>20050701</enddate><creator>Chung, Fu-Mei</creator><creator>Tsai, Jack C.-R</creator><creator>Chang, Dao-Ming</creator><creator>Shin, Shyi-Jang</creator><creator>Lee, Yau-Jiunn</creator><general>American Diabetes Association</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M2P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20050701</creationdate><title>Peripheral Total and Differential Leukocyte Count in Diabetic Nephropathy: The relationship of plasma leptin to leukocytosis</title><author>Chung, Fu-Mei ; Tsai, Jack C.-R ; Chang, Dao-Ming ; Shin, Shyi-Jang ; Lee, Yau-Jiunn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-f367t-df72b4b7a9abe7887ff12c63f661a7741e5fcc67a132d4ad6e9f9fe2f0b648003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Albuminuria</topic><topic>Biological and medical sciences</topic><topic>Biomarkers</topic><topic>Blood lipids</topic><topic>Case studies</topic><topic>Creatinine - blood</topic><topic>Cytokines</topic><topic>Diabetes</topic><topic>Diabetes. Impaired glucose tolerance</topic><topic>Diabetic nephropathies</topic><topic>Diabetic Nephropathies - blood</topic><topic>Diabetic Nephropathies - urine</topic><topic>Disease management</topic><topic>Endocrine pancreas. Apud cells (diseases)</topic><topic>Endocrinopathies</topic><topic>Enzymes</topic><topic>Etiopathogenesis. Screening. Investigations. Target tissue resistance</topic><topic>Female</topic><topic>Humans</topic><topic>Kidneys</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Leukocyte Count</topic><topic>Leukocyte disorders</topic><topic>Leukocytes</topic><topic>Leukocytosis - epidemiology</topic><topic>Lymphocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chung, Fu-Mei</creatorcontrib><creatorcontrib>Tsai, Jack C.-R</creatorcontrib><creatorcontrib>Chang, Dao-Ming</creatorcontrib><creatorcontrib>Shin, Shyi-Jang</creatorcontrib><creatorcontrib>Lee, Yau-Jiunn</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Agricultural Science Collection</collection><collection>Proquest Health & Medical Complete</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agriculture Science Database</collection><collection>Family Health Database (Proquest)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Health Management Database (Proquest)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>ProQuest Science Journals</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chung, Fu-Mei</au><au>Tsai, Jack C.-R</au><au>Chang, Dao-Ming</au><au>Shin, Shyi-Jang</au><au>Lee, Yau-Jiunn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peripheral Total and Differential Leukocyte Count in Diabetic Nephropathy: The relationship of plasma leptin to leukocytosis</atitle><jtitle>Diabetes care</jtitle><addtitle>Diabetes Care</addtitle><date>2005-07-01</date><risdate>2005</risdate><volume>28</volume><issue>7</issue><spage>1710</spage><epage>1717</epage><pages>1710-1717</pages><issn>0149-5992</issn><eissn>1935-5548</eissn><coden>DICAD2</coden><abstract>OBJECTIVE:--Because of increasing evidence that white blood cells (WBCs) play a role in the development and progression of diabetes complications, this study aimed to investigate the relation of circulating total and differential leukocyte counts to nephropathy in patients with type 2 diabetes. Plasma leptin levels were also measured to investigate their role in peripheral leukocytosis. RESEARCH DESIGN AND METHODS--For this study, 1,480 subjects with type 2 diabetes who were enrolled in a disease management program were stratified according to urinary microalbumin and serum creatinine measurements. The total and differential leukocyte profiles of peripheral blood were measured and plasma leptin was examined by enzyme-linked immunosorbent assay. Demographic and potential metabolic confounding factors were analyzed with linear and logistic regression to calculate the effects of leukocyte count on diabetic nephropathy. RESULTS:--The peripheral total WBC, monocyte, and neutrophil counts increased in parallel with the advancement of diabetic nephropathy. In contrast, the lymphocyte count decreased. When WBC counts were analyzed per quartile and as continuous variables after adjusting for age, sex, and other known risk factors with multiple regression analysis, peripheral total WBC, monocyte, neutrophil, and lymphocyte counts were independently and significantly associated with diabetic nephropathy. Plasma leptin levels increased in patients with nephropathy and correlated significantly with total WBC count (r = 0.194, P = 0.014). CONCLUSIONS:--Because leukocytes are activated and secrete cytokines in the diabetic state and leptin stimulates leukocyte proliferation and differentiation, our results suggest that circulating leukocytes contribute to the development and progression of nephropathy, partially through the effects of leptin, in patients with type 2 diabetes.</abstract><cop>Alexandria, VA</cop><pub>American Diabetes Association</pub><pmid>15983324</pmid><doi>10.2337/diacare.28.7.1710</doi><tpages>8</tpages></addata></record> |
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| subjects | Albuminuria Biological and medical sciences Biomarkers Blood lipids Case studies Creatinine - blood Cytokines Diabetes Diabetes. Impaired glucose tolerance Diabetic nephropathies Diabetic Nephropathies - blood Diabetic Nephropathies - urine Disease management Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzymes Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Humans Kidneys Leptin Leptin - blood Leukocyte Count Leukocyte disorders Leukocytes Leukocytosis - epidemiology Lymphocyte Count Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Regression Analysis Risk Factors Urinary system involvement in other diseases. Miscellaneous |
| title | Peripheral Total and Differential Leukocyte Count in Diabetic Nephropathy: The relationship of plasma leptin to leukocytosis |
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