Gene profiling in atherosclerosis reveals a key role for small inducible cytokines : Validation using a novel monocyte chemoattractant protein monoclonal antibody

Pathological aspects of atherosclerosis are well described, but gene profiles during atherosclerotic plaque progression are largely unidentified. Microarray analysis was performed on mRNA of aortic arches of ApoE-/- mice fed normal chow (NC group) or Western-type diet (WD group) for 3, 4.5, and 6 mo...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2005-06, Vol.111 (25), p.3443-3452
Hauptverfasser:	LUTGENS, Esther, FABER, Birgit, MACKAY, Charles R, RENNERT, Paul, BAILLY, Veronique, JARPE, Matthew, DOLINSKI, Brian, KOTELIANSKY, Victor, DE FOUGEROLLES, Tony, DAEMEN, Mat J. A. P, SCHAPIRA, Kitty, EVELO, Chris T. A, VAN HAAFTEN, Rachel, HEENEMAN, Sylvia, CLEUTJENS, Kitty B. J. M, BIJNENS, Ann Pascale, BECKERS, Linda, PORTER, J. Gordon
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - pharmacology Aorta, Thoracic Apolipoproteins E - deficiency Associated diseases and complications Atherosclerosis (general aspects, experimental research) Atherosclerosis - drug therapy Atherosclerosis - genetics Atherosclerosis - pathology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Chemokine CCL2 - immunology Chemokine CCL8 Chemokines - genetics Chemokines - physiology Cluster Analysis Diabetes. Impaired glucose tolerance Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endocrine pancreas. Apud cells (diseases) Endocrinopathies Extracellular Matrix - metabolism Gene Expression Profiling Inflammation - genetics Male Medical sciences Mice Mice, Knockout Monocyte Chemoattractant Proteins - immunology Monocyte Chemoattractant Proteins - physiology Peptide Hydrolases - genetics RNA, Messenger - analysis Time Factors
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