Suppression of lipid artifacts in amide proton transfer imaging
Amide proton transfer (APT) imaging is a type of chemical exchange saturation transfer imaging in which the amide protons of cellular proteins and peptides are saturated and detected via the water resonance. To study this effect, conventional magnetization transfer and direct saturation effects in t...
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| Veröffentlicht in: | Magnetic resonance in medicine 2005-07, Vol.54 (1), p.222-225 |
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| creator | Sun, Phillip Zhe Zhou, Jinyuan Sun, Weiyun Huang, Judy van Zijl, Peter C. M. |
| description | Amide proton transfer (APT) imaging is a type of chemical exchange saturation transfer imaging in which the amide protons of cellular proteins and peptides are saturated and detected via the water resonance. To study this effect, conventional magnetization transfer and direct saturation effects in the frequency‐dependent water saturation spectrum (z‐spectrum) need to be removed by asymmetry analysis with respect to the water frequency offset. When using echo planar imaging, it was found that unequal pericranial fat saturation at equidistant higher and lower frequencies with respect to water leads to a lipid artifact in APT asymmetry images. It is demonstrated that a chemical‐shift‐selective refocusing pulse in combination with crusher gradients can suppress this artifact and provide high‐quality images. Magn Reson Med 54:222–225, 2005. © 2005 Wiley‐Liss, Inc. |
| doi_str_mv | 10.1002/mrm.20530 |
| format | Article |
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M.</creatorcontrib><title>Suppression of lipid artifacts in amide proton transfer imaging</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>Amide proton transfer (APT) imaging is a type of chemical exchange saturation transfer imaging in which the amide protons of cellular proteins and peptides are saturated and detected via the water resonance. To study this effect, conventional magnetization transfer and direct saturation effects in the frequency‐dependent water saturation spectrum (z‐spectrum) need to be removed by asymmetry analysis with respect to the water frequency offset. When using echo planar imaging, it was found that unequal pericranial fat saturation at equidistant higher and lower frequencies with respect to water leads to a lipid artifact in APT asymmetry images. It is demonstrated that a chemical‐shift‐selective refocusing pulse in combination with crusher gradients can suppress this artifact and provide high‐quality images. Magn Reson Med 54:222–225, 2005. © 2005 Wiley‐Liss, Inc.</description><subject>amide proton</subject><subject>Amides - metabolism</subject><subject>Animals</subject><subject>APT</subject><subject>Brain - cytology</subject><subject>Brain - metabolism</subject><subject>CEST</subject><subject>Image Enhancement - methods</subject><subject>Lipid Metabolism</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>magnetization transfer</subject><subject>Male</subject><subject>mobile protein</subject><subject>Neuropeptides - metabolism</subject><subject>pH imaging</subject><subject>proton exchange</subject><subject>Protons</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>stroke</subject><subject>Water - metabolism</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMotj4W_gGZleBiNJkkk8lKpGgVtOILxU1IMzcSnZfJFPXfG23Vlbi6m--ce85BaIvgPYJxtl_7ei_DnOIlNCQ8y9KMS7aMhlgwnFIi2QCthfCEMZZSsFU0IFzmRZ7LITq4nnWdhxBc2yStTSrXuTLRvndWmz4krkl07UpIOt_2Eem9boIFn7haP7rmcQOtWF0F2FzcdXR7fHQzOknPLsano8Oz1DBJcQo5ZEZYpvVU5GBiJEmEpKaQBixhJiuIELYg0jDMQZrcWC2nhSgZMSUHQ9fRztw35niZQehV7YKBqtINtLOgciEFxZz_C8bXpIiZIrg7B41vQ_BgVedjKf-uCFafs6o4q_qaNbLbC9PZtIbyl1zsGIH9OfDqKnj_20mdX51_W6ZzhQs9vP0otH-OXajg6m4yVvnk8v7mhD6ojH4AQkmQ5g</recordid><startdate>200507</startdate><enddate>200507</enddate><creator>Sun, Phillip Zhe</creator><creator>Zhou, Jinyuan</creator><creator>Sun, Weiyun</creator><creator>Huang, Judy</creator><creator>van Zijl, Peter C. 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M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4930-e6e2c7f4aab76ec19491793c89cef14c28177f819c405e9c6cfa9b87d41cd5ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>amide proton</topic><topic>Amides - metabolism</topic><topic>Animals</topic><topic>APT</topic><topic>Brain - cytology</topic><topic>Brain - metabolism</topic><topic>CEST</topic><topic>Image Enhancement - methods</topic><topic>Lipid Metabolism</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>magnetization transfer</topic><topic>Male</topic><topic>mobile protein</topic><topic>Neuropeptides - metabolism</topic><topic>pH imaging</topic><topic>proton exchange</topic><topic>Protons</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>stroke</topic><topic>Water - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Phillip Zhe</creatorcontrib><creatorcontrib>Zhou, Jinyuan</creatorcontrib><creatorcontrib>Sun, Weiyun</creatorcontrib><creatorcontrib>Huang, Judy</creatorcontrib><creatorcontrib>van Zijl, Peter C. 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M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Suppression of lipid artifacts in amide proton transfer imaging</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2005-07</date><risdate>2005</risdate><volume>54</volume><issue>1</issue><spage>222</spage><epage>225</epage><pages>222-225</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><abstract>Amide proton transfer (APT) imaging is a type of chemical exchange saturation transfer imaging in which the amide protons of cellular proteins and peptides are saturated and detected via the water resonance. To study this effect, conventional magnetization transfer and direct saturation effects in the frequency‐dependent water saturation spectrum (z‐spectrum) need to be removed by asymmetry analysis with respect to the water frequency offset. When using echo planar imaging, it was found that unequal pericranial fat saturation at equidistant higher and lower frequencies with respect to water leads to a lipid artifact in APT asymmetry images. It is demonstrated that a chemical‐shift‐selective refocusing pulse in combination with crusher gradients can suppress this artifact and provide high‐quality images. Magn Reson Med 54:222–225, 2005. © 2005 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>15968669</pmid><doi>10.1002/mrm.20530</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Wiley Online Library (Open Access Collection) |
| subjects | amide proton Amides - metabolism Animals APT Brain - cytology Brain - metabolism CEST Image Enhancement - methods Lipid Metabolism Magnetic Resonance Imaging - methods magnetization transfer Male mobile protein Neuropeptides - metabolism pH imaging proton exchange Protons Rats Rats, Wistar stroke Water - metabolism |
| title | Suppression of lipid artifacts in amide proton transfer imaging |
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